YEAST:SUM1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	SUM1
Protein Name(s)	Suppressor of mar1-1 protein SUM1-1 protein
External Links
UniProt	P46676
EMBL	U34832 U28374 BK006938
PIR	S61196
RefSeq	NP_010596.1
ProteinModelPortal	P46676
BioGrid	32363
DIP	DIP-6438N
IntAct	P46676
MINT	MINT-2788081
iPTMnet	P46676
MaxQB	P46676
PeptideAtlas	P46676
EnsemblFungi	YDR310C
GeneID	851905
KEGG	sce:YDR310C
EuPathDB	FungiDB:YDR310C
SGD	S000002718
HOGENOM	HOG000065939
InParanoid	P46676
KO	K12779
OrthoDB	EOG7FJH8W
BioCyc	YEAST:G3O-29869-MONOMER
PRO	PR:P46676
Proteomes	UP000002311
GO	GO:0005634 GO:0003688 GO:0000978 GO:0001078 GO:0030466 GO:0010944 GO:0007070 GO:0032298 GO:0030435 GO:0006351

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:20608984^[1]	ECO:0000314			C		Immunofluorescence revealed that SUM1 was dispersed over the entire nucleus of the cell (Figure 4a).	complete CACAO 12215
	GO:0110029	negative regulation of meiosis I	PMID:20385771^[2]	ECO:0000315			P		Figs. 2 & 4 show that in S. cerevisiae, the sum1 gene is required for preventing sporulation.	complete CACAO 13424
	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:20385771^[2]	ECO:0000315			F		Figs. 4,5,and 6 show that in S. cerevisiae, Sum1 is required for repressing the NDT80 promoter.	complete CACAO 13429
enables	GO:0043565	sequence-specific DNA binding	PMID:19158363^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032298	positive regulation of DNA-dependent DNA replication initiation	PMID:16077008^[4]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000000264	P		Seeded From UniProt	complete
involved_in	GO:0032298	positive regulation of DNA-dependent DNA replication initiation	PMID:16077008^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000264 SGD:S000002175 SGD:S000003730 SGD:S000004093 SGD:S000005205	P		Seeded From UniProt	complete
involved_in	GO:0032298	positive regulation of DNA-dependent DNA replication initiation	PMID:16077008^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030466	chromatin silencing at silent mating-type cassette	PMID:16077008^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000002198	P		Seeded From UniProt	complete
involved_in	GO:0030466	chromatin silencing at silent mating-type cassette	PMID:16077008^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010944	negative regulation of transcription by competitive promoter binding	PMID:12832469^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10562556^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0000278)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8754829^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003688	DNA replication origin binding	PMID:16077008^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:12832469^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:12832469^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:12832469^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0030435	sporulation resulting in formation of a cellular spore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0749	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sarkar, S et al. (2010) The budding yeast protein Sum1 functions independently of its binding partners Hst1 and Sir2 histone deacetylases to regulate microtubule assembly. FEMS Yeast Res. 10 660-73 PubMed GONUTS page
↑ ^2.0 ^2.1 Shin, ME et al. (2010) The Cdk1 and Ime2 protein kinases trigger exit from meiotic prophase in Saccharomyces cerevisiae by inhibiting the Sum1 transcriptional repressor. Mol. Cell. Biol. 30 2996-3003 PubMed GONUTS page
↑ Zhu, C et al. (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res. 19 556-66 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Irlbacher, H et al. (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression. Genes Dev. 19 1811-22 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Pierce, M et al. (2003) Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression. Mol. Cell. Biol. 23 4814-25 PubMed GONUTS page
↑ Xie, J et al. (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J. 18 6448-54 PubMed GONUTS page
↑ Chi, MH & Shore, D (1996) SUM1-1, a dominant suppressor of SIR mutations in Saccharomyces cerevisiae, increases transcriptional silencing at telomeres and HM mating-type loci and decreases chromosome stability. Mol. Cell. Biol. 16 4281-94 PubMed GONUTS page

[PMID:20608984-1] Sarkar, S et al. (2010) The budding yeast protein Sum1 functions independently of its binding partners Hst1 and Sir2 histone deacetylases to regulate microtubule assembly. FEMS Yeast Res. 10 660-73 PubMed GONUTS page

[PMID:20385771-2] 2.0 ^2.1 Shin, ME et al. (2010) The Cdk1 and Ime2 protein kinases trigger exit from meiotic prophase in Saccharomyces cerevisiae by inhibiting the Sum1 transcriptional repressor. Mol. Cell. Biol. 30 2996-3003 PubMed GONUTS page

[PMID:19158363-3] Zhu, C et al. (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res. 19 556-66 PubMed GONUTS page

[PMID:16077008-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Irlbacher, H et al. (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression. Genes Dev. 19 1811-22 PubMed GONUTS page

[PMID:12832469-5] 5.0 ^5.1 ^5.2 ^5.3 Pierce, M et al. (2003) Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression. Mol. Cell. Biol. 23 4814-25 PubMed GONUTS page

[PMID:10562556-6] Xie, J et al. (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J. 18 6448-54 PubMed GONUTS page

[PMID:8754829-7] Chi, MH & Shore, D (1996) SUM1-1, a dominant suppressor of SIR mutations in Saccharomyces cerevisiae, increases transcriptional silencing at telomeres and HM mating-type loci and decreases chromosome stability. Mol. Cell. Biol. 16 4281-94 PubMed GONUTS page

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YEAST:SUM1

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