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YEAST:SUB1
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | SUB1 (synonyms: TSP1) | |
| Protein Name(s) | RNA polymerase II transcriptional coactivator SUB1 | |
| External Links | ||
| UniProt | P54000 | |
| EMBL | Z48502 BK006946 | |
| PIR | S52888 | |
| RefSeq | NP_013753.1 | |
| ProteinModelPortal | P54000 | |
| SMR | P54000 | |
| BioGrid | 35211 | |
| DIP | DIP-4696N | |
| IntAct | P54000 | |
| MINT | MINT-540355 | |
| iPTMnet | P54000 | |
| MaxQB | P54000 | |
| EnsemblFungi | YMR039C | |
| GeneID | 855055 | |
| KEGG | sce:YMR039C | |
| EuPathDB | FungiDB:YMR039C | |
| SGD | S000004642 | |
| GeneTree | ENSGT00390000008802 | |
| HOGENOM | HOG000000752 | |
| InParanoid | P54000 | |
| OMA | HEENIQN | |
| OrthoDB | EOG7BZW5P | |
| BioCyc | YEAST:G3O-32744-MONOMER | |
| PRO | PR:P54000 | |
| Proteomes | UP000002311 | |
| GO | GO:0005634 GO:0003682 GO:0003677 GO:0003713 GO:0006303 GO:0006972 GO:0075297 GO:0032968 GO:0045944 GO:0045945 GO:0043618 GO:0070898 GO:0006369 | |
| Gene3D | 2.30.31.10 | |
| InterPro | IPR003173 IPR009044 | |
| Pfam | PF02229 | |
| SUPFAM | SSF54447 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005654 |
nucleoplasm |
ECO:0000314 |
C |
Immunofluorescence revealed that SUB 1 was distributed uniformly throughout the nucleoplasm in both exponential and stationary phase (Figure 8). |
complete | |||||
| GO:0005730 |
nucleolus |
ECO:0000314 |
C |
Immunofluorescence revealed that SUB 1 localized within the nucleolus in both exponential and stationary phase (Figure 8). |
complete | |||||
| GO:0051053 |
negative regulation of DNA metabolic process |
ECO:0000315 |
P |
Paper’s Protein Name: Co-transcriptional activator Sub1. UniProt’s Protein Name: RNA polymerase II transcriptional coactivator SUB1. Organism: Saccharomyces cerevisiae (“all strains derived from YPH45”). Notes: Figure 1B is used. According to the paper “When highly transcribed, the rate of recombination for the pTET-lys2-GTOP was elevated by ∼7-fold in top1Δ sub1Δ strain compared to top1Δ (Figure 1B).” The chart indeed shows exactly this, although it doesn’t use the delta symbols on its labels. If recombination is elevated in Sub1’s absence, this implies that Sub1 negatively regulates DNA recombination. |
complete | |||||
|
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007329 |
positive regulation of transcription from RNA polymerase II promoter by pheromones |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075297 |
negative regulation of ascospore formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070898 |
RNA polymerase III preinitiation complex assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045945 |
positive regulation of transcription by RNA polymerase III |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000001733 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045945 |
positive regulation of transcription by RNA polymerase III |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045945 |
positive regulation of transcription by RNA polymerase III |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045945 |
positive regulation of transcription by RNA polymerase III |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045945 |
positive regulation of transcription by RNA polymerase III |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000353 |
physical interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0043618 |
regulation of transcription from RNA polymerase II promoter in response to stress |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000004103 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043618 |
regulation of transcription from RNA polymerase II promoter in response to stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043618 |
regulation of transcription from RNA polymerase II promoter in response to stress |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032968 |
positive regulation of transcription elongation from RNA polymerase II promoter |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006972 |
hyperosmotic response |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000003664 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006369 |
termination of RNA polymerase II transcription |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0006303 |
double-strand break repair via nonhomologous end joining |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003713 |
transcription coactivator activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003713 |
transcription coactivator activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
|
enables |
GO:0003713 |
transcription coactivator activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060261 |
positive regulation of transcription initiation from RNA polymerase II promoter |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000325022 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000325022 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0015299 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003713 |
transcription coactivator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000325022 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Acker, J et al. (2014) Sub1 and Maf1, two effectors of RNA polymerase III, are involved in the yeast quiescence cycle. PLoS ONE 9 e114587 PubMed GONUTS page
- ↑ Lopez, CR et al. (2017) Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA. Nucleic Acids Res. PubMed GONUTS page
- ↑ Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
- ↑ Sliva, A et al. (2016) Barcode Sequencing Screen Identifies SUB1 as a Regulator of Yeast Pheromone Inducible Genes. G3 (Bethesda) 6 881-92 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Gupta, R et al. (2015) SUB1 Plays a Negative Role during Starvation Induced Sporulation Program in Saccharomyces cerevisiae. PLoS ONE 10 e0132350 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Tavenet, A et al. (2009) Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription. Proc. Natl. Acad. Sci. U.S.A. 106 14265-70 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Rosonina, E et al. (2009) Sub1 functions in osmoregulation and in transcription by both RNA polymerases II and III. Mol. Cell. Biol. 29 2308-21 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Knaus, R et al. (1996) Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4. EMBO J. 15 1933-40 PubMed GONUTS page
- ↑ Calvo, O & Manley, JL (2005) The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription. EMBO J. 24 1009-20 PubMed GONUTS page
- ↑ Calvo, O & Manley, JL (2001) Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. Mol. Cell 7 1013-23 PubMed GONUTS page
- ↑ Yu, L & Volkert, MR (2013) Differential requirement for SUB1 in chromosomal and plasmid double-strand DNA break repair. PLoS ONE 8 e58015 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0045945 ! positive regulation of transcription by RNA polymerase III
- GO:0060261 ! positive regulation of transcription initiation by RNA polymerase II
- GO:0032968 ! positive regulation of transcription elongation by RNA polymerase II
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