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YEAST:SLI15
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | SLI15 | |
| Protein Name(s) | Inner centromere protein-related protein SLI15
INCENP-related protein SLI15 | |
| External Links | ||
| UniProt | P38283 | |
| EMBL | X71329 S59774 Z36025 BK006936 | |
| PIR | S46027 | |
| RefSeq | NP_009714.3 | |
| ProteinModelPortal | P38283 | |
| SMR | P38283 | |
| BioGrid | 32855 | |
| DIP | DIP-5807N | |
| IntAct | P38283 | |
| MINT | MINT-2787312 | |
| STRING | 4932.YBR156C | |
| iPTMnet | P38283 | |
| MaxQB | P38283 | |
| PRIDE | P38283 | |
| EnsemblFungi | YBR156C | |
| GeneID | 852453 | |
| KEGG | sce:YBR156C | |
| EuPathDB | FungiDB:YBR156C | |
| SGD | S000000360 | |
| InParanoid | P38283 | |
| OMA | IFGPIPP | |
| OrthoDB | EOG092C0VIB | |
| BioCyc | YEAST:G3O-29106-MONOMER | |
| PRO | PR:P38283 | |
| Proteomes | UP000002311 | |
| GO | GO:0032133 GO:0000777 GO:0005737 GO:0005828 GO:0005634 GO:0005876 GO:0051233 GO:0030295 GO:0007059 GO:0006468 GO:0032465 | |
| InterPro | IPR005635 | |
| Pfam | PF03941 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0072686 |
mitotic spindle |
ECO:0000314 |
C |
Fig. 8 shows sli15 being located on the mitotic spindle. Organism: S. cerevisiae |
complete | |||||
| GO:0032147 |
activation of protein kinase activity |
ECO:0000314 |
P |
Seen in figure 3, Ipl1 is activated by Sli15. Ipl1 is a protein kinase. Therefore, Sli15 activates protein kinase activity. Organism: S. cerevisiae |
complete | |||||
| GO:1990023 |
mitotic spindle midzone |
ECO:0000315 |
C |
Fig. 8 shows sli15 being located on mitotic spindle. However, phosphorylation of Sli15 may both reduce overall microtubule association and bias Sli15 localization towards the poles and away from the mid-zone of the anaphase spindle. Thus WITH OUT phosphorylation, microtubule association is at the mitotic spindle midzone. Organism: S. cerevisiae |
complete | |||||
|
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0051233 |
spindle midzone |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032465 |
regulation of cytokinesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032133 |
chromosome passenger complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030295 |
protein kinase activator activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005876 |
spindle microtubule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005828 |
kinetochore microtubule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032147 |
activation of protein kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0030295 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000776 |
kinetochore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000775 |
chromosome, centromeric region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000777 |
condensed chromosome kinetochore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005819 |
spindle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Makrantoni, V et al. (2014) Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae. PLoS ONE 9 e89399 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kim, JH et al. (1999) Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. J. Cell Biol. 145 1381-94 PubMed GONUTS page
- ↑ Buvelot, S et al. (2003) The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly. J. Cell Biol. 160 329-39 PubMed GONUTS page
- ↑ Norden, C et al. (2006) The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage. Cell 125 85-98 PubMed GONUTS page
- ↑ Nakajima, Y et al. (2009) Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae. Mol. Biol. Cell 20 1772-84 PubMed GONUTS page
- ↑ King, EM et al. (2007) Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores. Genes Dev. 21 1163-8 PubMed GONUTS page
- ↑ 7.0 7.1 Kang, J et al. (2001) Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J. Cell Biol. 155 763-74 PubMed GONUTS page
