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YEAST:RGT1
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | RGT1 | |
| Protein Name(s) | Glucose transport transcription regulator RGT1
Restores glucose transport protein 1 | |
| External Links | ||
| UniProt | P32862 | |
| EMBL | X69584 Z28038 BK006944 | |
| PIR | S30010 | |
| RefSeq | NP_012886.3 | |
| ProteinModelPortal | P32862 | |
| BioGrid | 34094 | |
| DIP | DIP-4177N | |
| IntAct | P32862 | |
| MINT | MINT-570679 | |
| STRING | 4932.YKL038W | |
| MaxQB | P32862 | |
| PaxDb | P32862 | |
| EnsemblFungi | [example_ID YKL038W] | |
| GeneID | 853828 | |
| KEGG | sce:YKL038W | |
| CYGD | YKL038w | |
| SGD | S000001521 | |
| eggNOG | NOG73252 | |
| GeneTree | ENSGT00530000067048 | |
| InParanoid | P32862 | |
| OMA | WFRNSLE | |
| OrthoDB | EOG7KWSRX | |
| BioCyc | YEAST:G3O-31839-MONOMER | |
| NextBio | 975023 | |
| Proteomes | UP000002311 | |
| Genevestigator | P32862 | |
| GO | GO:0005737 GO:0005634 GO:0003677 GO:0000978 GO:0001077 GO:0001191 GO:0008270 GO:0006006 GO:0015758 GO:0000122 GO:0045944 GO:0046324 | |
| Gene3D | 4.10.240.10 | |
| InterPro | IPR001138 | |
| Pfam | PF00172 | |
| SMART | SM00066 | |
| SUPFAM | SSF57701 | |
| PROSITE | PS00463 PS50048 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0030528 |
transcription regulator activity |
ECO:0000314 |
F |
Figure2:These results suggest that Mth1 may regulate the function of LexA-Rgt1 without directly affecting its DNA-binding ability. |
complete | |||||
|
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
| GO:0030528 |
transcription regulator activity |
ECO:0000314 |
F |
Figure 3: Consistently, LexA-Rgt1 (5SA) was shown to inhibit glucose-induced expression of the reporter gene. These results suggest that the function of the LexA-Rgt1 repressor, bound to the HXT promoters constitutively, is critically regulated by its phosphorylation state. |
complete | |||||
|
involved_in |
GO:0046324 |
regulation of glucose import |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Figure 1E: The reporter strains expressing the Rgt1 fusions were shown to grow only in glucose-containing medium (Fig. 1E), suggesting that the Rgt1 constructs repress expression of the HXT1 promoter in the absence of glucose but negatively regulated by glucose. |
complete | ||||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006006 |
glucose metabolic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000003850 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000305 |
curator inference used in manual assertion |
GO:0003677 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000000316 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Roy, A et al. (2014) Understanding the mechanism of glucose-induced relief of Rgt1-mediated repression in yeast. FEBS Open Bio 4 105-11 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Ozcan, S et al. (1996) Rgt1p of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription. Mol. Cell. Biol. 16 6419-26 PubMed GONUTS page
- ↑ Vallier, LG et al. (1994) Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae. Genetics 136 1279-85 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Kim, JH et al. (2003) Specificity and regulation of DNA binding by the yeast glucose transporter gene repressor Rgt1. Mol. Cell. Biol. 23 5208-16 PubMed GONUTS page
- ↑ Johnston, M (1999) Feasting, fasting and fermenting. Glucose sensing in yeast and other cells. Trends Genet. 15 29-33 PubMed GONUTS page
- ↑ Hazbun, TR & Fields, S (2002) A genome-wide screen for site-specific DNA-binding proteins. Mol. Cell Proteomics 1 538-43 PubMed GONUTS page
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