YEAST:PAT1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	PAT1 (synonyms: MRT1)
Protein Name(s)	DNA topoisomerase 2-associated protein PAT1 Decapping activator and translational repressor PAT1 Topoisomerase II-associated protein PAT1 mRNA turnover protein 1
External Links
UniProt	P25644
EMBL	X59720 BK006937
PIR	S53590
RefSeq	NP_010002.3
PDB	4BRW 4C8Q 4N0A 4OGP 4OJJ
PDBsum	4BRW 4C8Q 4N0A 4OGP 4OJJ
ProteinModelPortal	P25644
SMR	P25644
BioGrid	31052
DIP	DIP-883N
IntAct	P25644
MINT	MINT-414364
STRING	4932.YCR077C
MaxQB	P25644
PaxDb	P25644
PeptideAtlas	P25644
EnsemblFungi	[example_ID YCR077C]
GeneID	850440
KEGG	sce:YCR077C
CYGD	YCR077c
SGD	S000000673
eggNOG	NOG287050
HOGENOM	HOG000246501
InParanoid	P25644
KO	K12617
OMA	PHPFIAF
OrthoDB	EOG72RN6K
BioCyc	YEAST:G3O-29376-MONOMER
NextBio	966042
PRO	PR:P25644
Proteomes	UP000002311
Genevestigator	P25644
GO	GO:0005737 GO:0000932 GO:0010494 GO:0022627 GO:0000776 GO:0005634 GO:0003682 GO:0003729 GO:0007049 GO:0051301 GO:0061641 GO:0007059 GO:0033962 GO:0000290 GO:0001731 GO:0006397 GO:0045947 GO:0006446
InterPro	IPR019167
Pfam	PF09770

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005737	cytoplasm	PMID:22842922^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:23222640^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1990726	Lsm1-7-Pat1 complex	PMID:24139796^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:25035297^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:23893485^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045947	negative regulation of translational initiation	PMID:20832728^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045947	negative regulation of translational initiation	PMID:20832728^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033962	cytoplasmic mRNA processing body assembly	PMID:18981231^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000741 SGD:S000002319	P	part_of:(GO:0042149)	Seeded From UniProt	complete
involved_in	GO:0033962	cytoplasmic mRNA processing body assembly	PMID:18981231^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0042149)	Seeded From UniProt	complete
part_of	GO:0022627	cytosolic small ribosomal subunit	PMID:10779343^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	PMID:23222640^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
involved_in	GO:0006446	regulation of translational initiation	PMID:10779343^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23706738^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23706738^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:23222640^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:23706738^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001731	formation of translation preinitiation complex	PMID:20832728^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:12730603^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:12730603^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	PMID:10913177^[11]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000003660	P		Seeded From UniProt	complete
involved_in	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	PMID:10913177^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033962	cytoplasmic mRNA processing body assembly	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0266053 PANTHER:PTN000489218 SGD:S000000673 UniProtKB:Q86TB9	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000489218 SGD:S000000673 UniProtKB:Q86TB9	F		Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0266053 MGI:MGI:1914828 PANTHER:PTN000489218 PomBase:SPBC19G7.10c SGD:S000000673 TAIR:locus:2207400 UniProtKB:Q5B9M9 UniProtKB:Q86TB9 WB:WBGene00009661	C		Seeded From UniProt	complete
involved_in	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0266053 PANTHER:PTN000489218 PomBase:SPBC19G7.10c SGD:S000000673 TAIR:locus:2207400 UniProtKB:Q86TB9	P		Seeded From UniProt	complete
involved_in	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039900	P		Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0230	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tkach, JM et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat. Cell Biol. 14 966-76 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Mitchell, SF et al. (2013) Global analysis of yeast mRNPs. Nat. Struct. Mol. Biol. 20 127-33 PubMed GONUTS page
↑ Sharif, H & Conti, E (2013) Architecture of the Lsm1-7-Pat1 complex: a conserved assembly in eukaryotic mRNA turnover. Cell Rep 5 283-91 PubMed GONUTS page
↑ Chowdhury, A et al. (2014) Pat1 contributes to the RNA binding activity of the Lsm1-7-Pat1 complex. RNA 20 1465-75 PubMed GONUTS page
↑ Mishra, PK et al. (2013) Structural integrity of centromeric chromatin and faithful chromosome segregation requires Pat1. Genetics 195 369-79 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Nissan, T et al. (2010) Decapping activators in Saccharomyces cerevisiae act by multiple mechanisms. Mol. Cell 39 773-83 PubMed GONUTS page
↑ ^7.0 ^7.1 Buchan, JR et al. (2008) P bodies promote stress granule assembly in Saccharomyces cerevisiae. J. Cell Biol. 183 441-55 PubMed GONUTS page
↑ ^8.0 ^8.1 Wyers, F et al. (2000) Deletion of the PAT1 gene affects translation initiation and suppresses a PAB1 gene deletion in yeast. Mol. Cell. Biol. 20 3538-49 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Haimovich, G et al. (2013) Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis. Cell 153 1000-11 PubMed GONUTS page
↑ ^10.0 ^10.1 Sheth, U & Parker, R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300 805-8 PubMed GONUTS page
↑ ^11.0 ^11.1 Bonnerot, C et al. (2000) The two proteins Pat1p (Mrt1p) and Spb8p interact in vivo, are required for mRNA decay, and are functionally linked to Pab1p. Mol. Cell. Biol. 20 5939-46 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22842922-1] Tkach, JM et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat. Cell Biol. 14 966-76 PubMed GONUTS page

[PMID:23222640-2] 2.0 ^2.1 ^2.2 Mitchell, SF et al. (2013) Global analysis of yeast mRNPs. Nat. Struct. Mol. Biol. 20 127-33 PubMed GONUTS page

[PMID:24139796-3] Sharif, H & Conti, E (2013) Architecture of the Lsm1-7-Pat1 complex: a conserved assembly in eukaryotic mRNA turnover. Cell Rep 5 283-91 PubMed GONUTS page

[PMID:25035297-4] Chowdhury, A et al. (2014) Pat1 contributes to the RNA binding activity of the Lsm1-7-Pat1 complex. RNA 20 1465-75 PubMed GONUTS page

[PMID:23893485-5] Mishra, PK et al. (2013) Structural integrity of centromeric chromatin and faithful chromosome segregation requires Pat1. Genetics 195 369-79 PubMed GONUTS page

[PMID:20832728-6] 6.0 ^6.1 ^6.2 Nissan, T et al. (2010) Decapping activators in Saccharomyces cerevisiae act by multiple mechanisms. Mol. Cell 39 773-83 PubMed GONUTS page

[PMID:18981231-7] 7.0 ^7.1 Buchan, JR et al. (2008) P bodies promote stress granule assembly in Saccharomyces cerevisiae. J. Cell Biol. 183 441-55 PubMed GONUTS page

[PMID:10779343-8] 8.0 ^8.1 Wyers, F et al. (2000) Deletion of the PAT1 gene affects translation initiation and suppresses a PAB1 gene deletion in yeast. Mol. Cell. Biol. 20 3538-49 PubMed GONUTS page

[PMID:23706738-9] 9.0 ^9.1 ^9.2 Haimovich, G et al. (2013) Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis. Cell 153 1000-11 PubMed GONUTS page

[PMID:12730603-10] 10.0 ^10.1 Sheth, U & Parker, R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300 805-8 PubMed GONUTS page

[PMID:10913177-11] 11.0 ^11.1 Bonnerot, C et al. (2000) The two proteins Pat1p (Mrt1p) and Spb8p interact in vivo, are required for mRNA decay, and are functionally linked to Pab1p. Mol. Cell. Biol. 20 5939-46 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:PAT1

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