YEAST:NUP60

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	NUP60 (synonyms: FUN17)
Protein Name(s)	Nucleoporin NUP60 Nuclear pore protein NUP60
External Links
UniProt	P39705
EMBL	L22015 AY692943 BK006935
PIR	S40900
RefSeq	NP_009401.1
ProteinModelPortal	P39705
BioGrid	31790
DIP	DIP-5821N
IntAct	P39705
MINT	P39705
STRING	4932.YAR002W
TCDB	1.I.1.1.1
iPTMnet	P39705
MaxQB	P39705
PaxDb	P39705
PRIDE	P39705
DNASU	851263
EnsemblFungi	YAR002W
GeneID	851263
KEGG	sce:YAR002W
EuPathDB	FungiDB:YAR002W
SGD	S000000063
InParanoid	P39705
KO	K18718
OMA	IEYEGVM
OrthoDB	EOG092C2FN5
BioCyc	YEAST:G3O-28867-MONOMER
PRO	PR:P39705
Proteomes	UP000002311
GO	GO:0005829 GO:0031965 GO:0005643 GO:0044613 GO:0044615 GO:0005634 GO:0005543 GO:0017056 GO:0030466 GO:0051276 GO:0006302 GO:0008298 GO:0031990 GO:0006607 GO:0006913 GO:0016973 GO:0000973 GO:0006611 GO:0060188 GO:0034398 GO:0000972
InterPro	IPR034432
PANTHER	PTHR28284

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0060188	regulation of protein desumoylation	PMID:17403926^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000005941	P		Seeded From UniProt	complete
involved_in	GO:0051276	chromosome organization	PMID:21818277^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0044615	nuclear pore nuclear basket	PMID:10684247^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044613	nuclear pore central transport channel	PMID:18046406^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034398	telomere tethering at nuclear periphery	PMID:21818277^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034398	telomere tethering at nuclear periphery	PMID:11862215^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031990	mRNA export from nucleus in response to heat stress	PMID:18258809^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030466	chromatin silencing at silent mating-type cassette	PMID:21818277^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	PMID:17418788^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016973	poly(A)+ mRNA export from nucleus	PMID:12411502^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016973	poly(A)+ mRNA export from nucleus	PMID:21036941^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008298	intracellular mRNA localization	PMID:21036941^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006913	nucleocytoplasmic transport	PMID:11535617^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006611	protein export from nucleus	PMID:11535617^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006607	NLS-bearing protein import into nucleus	PMID:15039779^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000001377 SGD:S000002600 SGD:S000004327 SGD:S000005624	P		Seeded From UniProt	complete
involved_in	GO:0006607	NLS-bearing protein import into nucleus	PMID:11535617^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:17538013^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22932476^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071456)	Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	PMID:10684247^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22932476^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:17897934^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	PMID:17418788^[7]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000004339	F		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	PMID:11387327^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000912 SGD:S000004284 SGD:S000004339	F		Seeded From UniProt	complete
involved_in	GO:0000973	posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery	PMID:20932479^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	PMID:20098417^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	PMID:21036941^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	PMID:20932479^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034398	telomere tethering at nuclear periphery	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002001446 SGD:S000000063	P		Seeded From UniProt	complete
involved_in	GO:0031990	mRNA export from nucleus in response to heat stress	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002001446 SGD:S000000063	P		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002001446 SGD:S000000063	F		Seeded From UniProt	complete
involved_in	GO:0016973	poly(A)+ mRNA export from nucleus	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002001446 SGD:S000000063	P		Seeded From UniProt	complete
involved_in	GO:0008298	intracellular mRNA localization	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002001446 SGD:S000000063	P		Seeded From UniProt	complete
involved_in	GO:0006611	protein export from nucleus	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002001446 SGD:S000000063	P		Seeded From UniProt	complete
involved_in	GO:0006607	NLS-bearing protein import into nucleus	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002001446 SGD:S000000063	P		Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002001446 PomBase:SPCC285.13c SGD:S000000063	C		Seeded From UniProt	complete
involved_in	GO:0006913	nucleocytoplasmic transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034432	P		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034432	F		Seeded From UniProt	complete
part_of	GO:0044615	nuclear pore nuclear basket	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034432	C		Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0906 UniProtKB-SubCell:SL-0185	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0509	P		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0811 UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Makhnevych, T et al. (2007) The role of karyopherins in the regulated sumoylation of septins. J. Cell Biol. 177 39-49 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Ruben, GJ et al. (2011) Nucleoporin mediated nuclear positioning and silencing of HMR. PLoS ONE 6 e21923 PubMed GONUTS page
↑ ^3.0 ^3.1 Rout, MP et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148 635-51 PubMed GONUTS page
↑ Alber, F et al. (2007) The molecular architecture of the nuclear pore complex. Nature 450 695-701 PubMed GONUTS page
↑ Feuerbach, F et al. (2002) Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast. Nat. Cell Biol. 4 214-21 PubMed GONUTS page
↑ Thomsen, R et al. (2008) General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutants. RNA 14 706-16 PubMed GONUTS page
↑ ^7.0 ^7.1 Patel, SS et al. (2007) Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex. Cell 129 83-96 PubMed GONUTS page
↑ Fischer, T et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J. 21 5843-52 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Powrie, EA et al. (2011) A nucleoporin, Nup60p, affects the nuclear and cytoplasmic localization of ASH1 mRNA in S. cerevisiae. RNA 17 134-44 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Denning, D et al. (2001) The nucleoporin Nup60p functions as a Gsp1p-GTP-sensitive tether for Nup2p at the nuclear pore complex. J. Cell Biol. 154 937-50 PubMed GONUTS page
↑ Strawn, LA et al. (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat. Cell Biol. 6 197-206 PubMed GONUTS page
↑ Palancade, B et al. (2007) Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes. Mol. Biol. Cell 18 2912-23 PubMed GONUTS page
↑ ^13.0 ^13.1 Dastidar, RG et al. (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2 30 PubMed GONUTS page
↑ Patel, SS & Rexach, MF (2008) Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibrium. Mol. Cell Proteomics 7 121-31 PubMed GONUTS page
↑ Allen, NP et al. (2001) Proteomic analysis of nucleoporin interacting proteins. J. Biol. Chem. 276 29268-74 PubMed GONUTS page
↑ ^16.0 ^16.1 Light, WH et al. (2010) Interaction of a DNA zip code with the nuclear pore complex promotes H2A.Z incorporation and INO1 transcriptional memory. Mol. Cell 40 112-25 PubMed GONUTS page
↑ Ahmed, S et al. (2010) DNA zip codes control an ancient mechanism for gene targeting to the nuclear periphery. Nat. Cell Biol. 12 111-8 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17403926-1] Makhnevych, T et al. (2007) The role of karyopherins in the regulated sumoylation of septins. J. Cell Biol. 177 39-49 PubMed GONUTS page

[PMID:21818277-2] 2.0 ^2.1 ^2.2 Ruben, GJ et al. (2011) Nucleoporin mediated nuclear positioning and silencing of HMR. PLoS ONE 6 e21923 PubMed GONUTS page

[PMID:10684247-3] 3.0 ^3.1 Rout, MP et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148 635-51 PubMed GONUTS page

[PMID:18046406-4] Alber, F et al. (2007) The molecular architecture of the nuclear pore complex. Nature 450 695-701 PubMed GONUTS page

[PMID:11862215-5] Feuerbach, F et al. (2002) Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast. Nat. Cell Biol. 4 214-21 PubMed GONUTS page

[PMID:18258809-6] Thomsen, R et al. (2008) General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutants. RNA 14 706-16 PubMed GONUTS page

[PMID:17418788-7] 7.0 ^7.1 Patel, SS et al. (2007) Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex. Cell 129 83-96 PubMed GONUTS page

[PMID:12411502-8] Fischer, T et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J. 21 5843-52 PubMed GONUTS page

[PMID:21036941-9] 9.0 ^9.1 ^9.2 Powrie, EA et al. (2011) A nucleoporin, Nup60p, affects the nuclear and cytoplasmic localization of ASH1 mRNA in S. cerevisiae. RNA 17 134-44 PubMed GONUTS page

[PMID:11535617-10] 10.0 ^10.1 ^10.2 Denning, D et al. (2001) The nucleoporin Nup60p functions as a Gsp1p-GTP-sensitive tether for Nup2p at the nuclear pore complex. J. Cell Biol. 154 937-50 PubMed GONUTS page

[PMID:15039779-11] Strawn, LA et al. (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat. Cell Biol. 6 197-206 PubMed GONUTS page

[PMID:17538013-12] Palancade, B et al. (2007) Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes. Mol. Biol. Cell 18 2912-23 PubMed GONUTS page

[PMID:22932476-13] 13.0 ^13.1 Dastidar, RG et al. (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2 30 PubMed GONUTS page

[PMID:17897934-14] Patel, SS & Rexach, MF (2008) Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibrium. Mol. Cell Proteomics 7 121-31 PubMed GONUTS page

[PMID:11387327-15] Allen, NP et al. (2001) Proteomic analysis of nucleoporin interacting proteins. J. Biol. Chem. 276 29268-74 PubMed GONUTS page

[PMID:20932479-16] 16.0 ^16.1 Light, WH et al. (2010) Interaction of a DNA zip code with the nuclear pore complex promotes H2A.Z incorporation and INO1 transcriptional memory. Mol. Cell 40 112-25 PubMed GONUTS page

[PMID:20098417-17] Ahmed, S et al. (2010) DNA zip codes control an ancient mechanism for gene targeting to the nuclear periphery. Nat. Cell Biol. 12 111-8 PubMed GONUTS page

[PMID:21873635-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:NUP60

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