YEAST:NU133

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	NUP133 (synonyms: RAT3)
Protein Name(s)	Nucleoporin NUP133 Nuclear pore protein NUP133
External Links
UniProt	P36161
EMBL	X80066 Z27116 Z28307 BK006944
PIR	S38160
RefSeq	NP_013008.3
PDB	3KFO
PDBsum	3KFO
ProteinModelPortal	P36161
SMR	P36161
BioGrid	34213
DIP	DIP-2428N
IntAct	P36161
MINT	MINT-525921
STRING	4932.YKR082W
TCDB	1.I.1.1.1
MaxQB	P36161
PaxDb	P36161
PeptideAtlas	P36161
DNASU	853957
EnsemblFungi	[example_ID YKR082W]
GeneID	853957
KEGG	sce:YKR082W
CYGD	YKR082w
SGD	S000001790
eggNOG	NOG296620
HOGENOM	HOG000113873
InParanoid	P36161
KO	K14300
OMA	LPWFINF
OrthoDB	EOG73BVMX
BioCyc	YEAST:G3O-32045-MONOMER
EvolutionaryTrace	P36161
NextBio	975374
Proteomes	UP000002311
Genevestigator	P36161
GO	GO:0005829 GO:0031965 GO:0005643 GO:0031080 GO:0005634 GO:0017056 GO:0030466 GO:0006302 GO:0035392 GO:0031990 GO:0000122 GO:0031081 GO:0016973 GO:0045944 GO:0045893 GO:0000973 GO:0006606 GO:0034398 GO:0006409
Gene3D	2.130.10.10
InterPro	IPR007187 IPR014908 IPR015943
Pfam	PF03177 PF08801

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22110603^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15817685^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000005996	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15817685^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035392	maintenance of chromatin silencing at telomere	PMID:16418532^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034398	telomere tethering at nuclear periphery	PMID:16418532^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031990	mRNA export from nucleus in response to heat stress	PMID:18258809^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031081	nuclear pore distribution	PMID:7813444^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031081	nuclear pore distribution	PMID:7862658^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031081	nuclear pore distribution	PMID:9725905^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031081	nuclear pore distribution	PMID:22331846^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031080	nuclear pore outer ring	PMID:18046406^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031080	nuclear pore outer ring	PMID:11823431^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030466	chromatin silencing at silent mating-type cassette	PMID:21818277^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	PMID:22331846^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016973	poly(A)+ mRNA export from nucleus	PMID:21036941^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016973	poly(A)+ mRNA export from nucleus	PMID:7813444^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	PMID:12730220^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P32835) happens_during:(GO:0034605)	Seeded From UniProt	complete
involved_in	GO:0006409	tRNA export from nucleus	PMID:8524308^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:15725626^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000001596	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:17538013^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:16418532^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22932476^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071456)	Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	PMID:10684247^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22932476^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000973	posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery	PMID:20932479^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:22110603^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031081	nuclear pore distribution	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000334066 SGD:S000001790	P		Seeded From UniProt	complete
part_of	GO:0031080	nuclear pore outer ring	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000334066 PomBase:SPAC1805.04 PomBase:SPBP35G2.06c SGD:S000001790 UniProtKB:Q8WUM0	C		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000334066 SGD:S000001790 UniProtKB:Q8WUM0	F		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000334066 SGD:S000001790	P		Seeded From UniProt	complete
colocalizes_with	GO:0000777	condensed chromosome kinetochore	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000334066 UniProtKB:Q8WUM0	C		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035392	C		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037624	F		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653 UniProtKB-KW:KW-0811	P		Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0509	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0906 UniProtKB-SubCell:SL-0185	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Sarma, NJ et al. (2011) The nuclear pore complex mediates binding of the Mig1 repressor to target promoters. PLoS ONE 6 e27117 PubMed GONUTS page
↑ ^2.0 ^2.1 Menon, BB et al. (2005) Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Proc. Natl. Acad. Sci. U.S.A. 102 5749-54 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Therizols, P et al. (2006) Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region. J. Cell Biol. 172 189-99 PubMed GONUTS page
↑ Thomsen, R et al. (2008) General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutants. RNA 14 706-16 PubMed GONUTS page
↑ ^5.0 ^5.1 Doye, V et al. (1994) A novel nuclear pore protein Nup133p with distinct roles in poly(A)+ RNA transport and nuclear pore distribution. EMBO J. 13 6062-75 PubMed GONUTS page
↑ Pemberton, LF et al. (1995) Disruption of the nucleoporin gene NUP133 results in clustering of nuclear pore complexes. Proc. Natl. Acad. Sci. U.S.A. 92 1187-91 PubMed GONUTS page
↑ Bucci, M & Wente, SR (1998) A novel fluorescence-based genetic strategy identifies mutants of Saccharomyces cerevisiae defective for nuclear pore complex assembly. Mol. Biol. Cell 9 2439-61 PubMed GONUTS page
↑ ^8.0 ^8.1 Fernandez-Martinez, J et al. (2012) Structure-function mapping of a heptameric module in the nuclear pore complex. J. Cell Biol. 196 419-34 PubMed GONUTS page
↑ Alber, F et al. (2007) The molecular architecture of the nuclear pore complex. Nature 450 695-701 PubMed GONUTS page
↑ Lutzmann, M et al. (2002) Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins. EMBO J. 21 387-97 PubMed GONUTS page
↑ Ruben, GJ et al. (2011) Nucleoporin mediated nuclear positioning and silencing of HMR. PLoS ONE 6 e21923 PubMed GONUTS page
↑ Powrie, EA et al. (2011) A nucleoporin, Nup60p, affects the nuclear and cytoplasmic localization of ASH1 mRNA in S. cerevisiae. RNA 17 134-44 PubMed GONUTS page
↑ Gao, H et al. (2003) Nuclear accumulation of the small GTPase Gsp1p depends on nucleoporins Nup133p, Rat2p/Nup120p, Nup85p, Nic96p, and the acetyl-CoA carboxylase Acc1p. J. Biol. Chem. 278 25331-40 PubMed GONUTS page
↑ Sharma, K et al. (1996) Yeast nucleoporin mutants are defective in pre-tRNA splicing. Mol. Cell. Biol. 16 294-301 PubMed GONUTS page
↑ Loeillet, S et al. (2005) Genetic network interactions among replication, repair and nuclear pore deficiencies in yeast. DNA Repair (Amst.) 4 459-68 PubMed GONUTS page
↑ Palancade, B et al. (2007) Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes. Mol. Biol. Cell 18 2912-23 PubMed GONUTS page
↑ ^17.0 ^17.1 Dastidar, RG et al. (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2 30 PubMed GONUTS page
↑ Rout, MP et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148 635-51 PubMed GONUTS page
↑ Light, WH et al. (2010) Interaction of a DNA zip code with the nuclear pore complex promotes H2A.Z incorporation and INO1 transcriptional memory. Mol. Cell 40 112-25 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22110603-1] 1.0 ^1.1 Sarma, NJ et al. (2011) The nuclear pore complex mediates binding of the Mig1 repressor to target promoters. PLoS ONE 6 e27117 PubMed GONUTS page

[PMID:15817685-2] 2.0 ^2.1 Menon, BB et al. (2005) Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Proc. Natl. Acad. Sci. U.S.A. 102 5749-54 PubMed GONUTS page

[PMID:16418532-3] 3.0 ^3.1 ^3.2 Therizols, P et al. (2006) Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region. J. Cell Biol. 172 189-99 PubMed GONUTS page

[PMID:18258809-4] Thomsen, R et al. (2008) General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutants. RNA 14 706-16 PubMed GONUTS page

[PMID:7813444-5] 5.0 ^5.1 Doye, V et al. (1994) A novel nuclear pore protein Nup133p with distinct roles in poly(A)+ RNA transport and nuclear pore distribution. EMBO J. 13 6062-75 PubMed GONUTS page

[PMID:7862658-6] Pemberton, LF et al. (1995) Disruption of the nucleoporin gene NUP133 results in clustering of nuclear pore complexes. Proc. Natl. Acad. Sci. U.S.A. 92 1187-91 PubMed GONUTS page

[PMID:9725905-7] Bucci, M & Wente, SR (1998) A novel fluorescence-based genetic strategy identifies mutants of Saccharomyces cerevisiae defective for nuclear pore complex assembly. Mol. Biol. Cell 9 2439-61 PubMed GONUTS page

[PMID:22331846-8] 8.0 ^8.1 Fernandez-Martinez, J et al. (2012) Structure-function mapping of a heptameric module in the nuclear pore complex. J. Cell Biol. 196 419-34 PubMed GONUTS page

[PMID:18046406-9] Alber, F et al. (2007) The molecular architecture of the nuclear pore complex. Nature 450 695-701 PubMed GONUTS page

[PMID:11823431-10] Lutzmann, M et al. (2002) Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins. EMBO J. 21 387-97 PubMed GONUTS page

[PMID:21818277-11] Ruben, GJ et al. (2011) Nucleoporin mediated nuclear positioning and silencing of HMR. PLoS ONE 6 e21923 PubMed GONUTS page

[PMID:21036941-12] Powrie, EA et al. (2011) A nucleoporin, Nup60p, affects the nuclear and cytoplasmic localization of ASH1 mRNA in S. cerevisiae. RNA 17 134-44 PubMed GONUTS page

[PMID:12730220-13] Gao, H et al. (2003) Nuclear accumulation of the small GTPase Gsp1p depends on nucleoporins Nup133p, Rat2p/Nup120p, Nup85p, Nic96p, and the acetyl-CoA carboxylase Acc1p. J. Biol. Chem. 278 25331-40 PubMed GONUTS page

[PMID:8524308-14] Sharma, K et al. (1996) Yeast nucleoporin mutants are defective in pre-tRNA splicing. Mol. Cell. Biol. 16 294-301 PubMed GONUTS page

[PMID:15725626-15] Loeillet, S et al. (2005) Genetic network interactions among replication, repair and nuclear pore deficiencies in yeast. DNA Repair (Amst.) 4 459-68 PubMed GONUTS page

[PMID:17538013-16] Palancade, B et al. (2007) Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes. Mol. Biol. Cell 18 2912-23 PubMed GONUTS page

[PMID:22932476-17] 17.0 ^17.1 Dastidar, RG et al. (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2 30 PubMed GONUTS page

[PMID:10684247-18] Rout, MP et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148 635-51 PubMed GONUTS page

[PMID:20932479-19] Light, WH et al. (2010) Interaction of a DNA zip code with the nuclear pore complex promotes H2A.Z incorporation and INO1 transcriptional memory. Mol. Cell 40 112-25 PubMed GONUTS page

[PMID:21873635-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:NU133

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