YEAST:MYO2

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	MYO2 (synonyms: CDC66)
Protein Name(s)	Myosin-2 Cell division control protein 66 Class V unconventional myosin MYO2 Type V myosin heavy chain MYO2 Myosin V MYO2
External Links
UniProt	P19524
EMBL	M35532 Z75234 Z75235 X90565 Z49821 BK006948
PIR	A38454
RefSeq	NP_014971.1
PDB	1M45 1M46 1N2D 2F6H
PDBsum	1M45 1M46 1N2D 2F6H
ProteinModelPortal	P19524
SMR	P19524
BioGrid	34711
DIP	DIP-2308N
IntAct	P19524
MINT	MINT-440498
STRING	4932.YOR326W
MaxQB	P19524
PaxDb	P19524
PeptideAtlas	P19524
EnsemblFungi	[example_ID YOR326W]
GeneID	854504
KEGG	sce:YOR326W
CYGD	YOR326w
SGD	S000005853
eggNOG	COG5022
GeneTree	ENSGT00770000120617
HOGENOM	HOG000171839
InParanoid	P19524
KO	K10357
OMA	METIRVC
OrthoDB	EOG77T1CS
BioCyc	YEAST:G3O-33803-MONOMER
EvolutionaryTrace	P19524
NextBio	976849
PRO	PR:P19524
Proteomes	UP000002311
Genevestigator	P19524
GO	GO:0032432 GO:0005935 GO:0005934 GO:0031941 GO:0000131 GO:0043332 GO:0071563 GO:0031475 GO:0030133 GO:0031982 GO:0051015 GO:0005524 GO:0005516 GO:0000146 GO:0007118 GO:0000132 GO:0048313 GO:0007107 GO:0008152 GO:0000001 GO:0045033 GO:0015031 GO:0009826 GO:0000011 GO:0030050 GO:0016192
Gene3D	3.40.50.300
InterPro	IPR018444 IPR002710 IPR000048 IPR001609 IPR008989 IPR027417
Pfam	PF01843 PF00063
PRINTS	PR00193
SMART	SM00015 SM00242
SUPFAM	SSF50084 SSF52540
PROSITE	PS51126 PS50096 PS51456

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0040007	growth	PMID:2016335^[1]	ECO:0000315			P	Figure 5. The myo2-66 mutation disrupts actin cables. Proliferating homozygous myo2-66 (B, D, F) or wad-type (A, C, E) diploid cells.	complete CACAO 3448
part_of	GO:0043332	mating projection tip	PMID:19053807^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006904	vesicle docking involved in exocytosis	PMID:27307583^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P32364	P	Seeded From UniProt	complete
part_of	GO:0071563	Myo2p-Vac17p-Vac8p transport complex	PMID:12594460^[4]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000000568	C	Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:11381095^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0048313	Golgi inheritance	PMID:11285273^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045033	peroxisome inheritance	PMID:16678774^[7]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000004773	P	Seeded From UniProt	complete
involved_in	GO:0045033	peroxisome inheritance	PMID:11733545^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043332	mating projection tip	PMID:8188749^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032432	actin filament bundle	PMID:9864365^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:12456647^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0031941	filamentous actin	PMID:11381095^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	PMID:23079598^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030050	vesicle transport along actin filament	PMID:10562281^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030050	vesicle transport along actin filament	PMID:9864365^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	PMID:9864365^[10]	ECO:0000316	genetic interaction evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
involved_in	GO:0016192	vesicle-mediated transport	PMID:2016335^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009826	unidimensional cell growth	PMID:9864365^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007118	budding cell apical bud growth	PMID:2016335^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007107	membrane addition at site of cytokinesis	PMID:12456647^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000003074	P	Seeded From UniProt	complete
involved_in	GO:0007107	membrane addition at site of cytokinesis	PMID:12456647^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005935	cellular bud neck	PMID:8188749^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005934	cellular bud tip	PMID:8188749^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:8294515^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0000329	fungal-type vacuole membrane	PMID:8978821^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0000146	microfilament motor activity	PMID:11381095^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	PMID:10984058^[16]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000006190	P	Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	PMID:10984058^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000131	incipient cellular bud site	PMID:8188749^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000011	vacuole inheritance	PMID:12594460^[4]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000000568	P	Seeded From UniProt	complete
involved_in	GO:0000011	vacuole inheritance	PMID:12594460^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000568	P	Seeded From UniProt	complete
involved_in	GO:0000011	vacuole inheritance	PMID:8978821^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000001	mitochondrion inheritance	PMID:15201867^[17]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000004180	P	Seeded From UniProt	complete
involved_in	GO:0000001	mitochondrion inheritance	PMID:15201867^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000004180	P	Seeded From UniProt	complete
involved_in	GO:0000001	mitochondrion inheritance	PMID:12391144^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000005248	P	Seeded From UniProt	complete
involved_in	GO:0000001	mitochondrion inheritance	PMID:12391144^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003774	motor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001609 InterPro:IPR004009 InterPro:IPR008989	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001609 InterPro:IPR004009 InterPro:IPR008989	F	Seeded From UniProt	complete
part_of	GO:0016459	myosin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001609 InterPro:IPR004009	C	Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008989	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F	Seeded From UniProt	complete
part_of	GO:0016459	myosin complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0518	C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F	Seeded From UniProt	complete
part_of	GO:0005934	cellular bud tip	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0030	C	Seeded From UniProt	complete
part_of	GO:0005935	cellular bud neck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0029	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Johnston, GC et al. (1991) The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles. J. Cell Biol. 113 539-51 PubMed GONUTS page
↑ Narayanaswamy, R et al. (2009) Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast. J. Proteome Res. 8 6-19 PubMed GONUTS page
↑ Lwin, KM et al. (2016) Kinesin-related Smy1 enhances the Rab-dependent association of myosin-V with secretory cargo. Mol. Biol. Cell 27 2450-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Tang, F et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422 87-92 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Reck-Peterson, SL et al. (2001) The yeast class V myosins, Myo2p and Myo4p, are nonprocessive actin-based motors. J. Cell Biol. 153 1121-6 PubMed GONUTS page
↑ Rossanese, OW et al. (2001) A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae. J. Cell Biol. 153 47-62 PubMed GONUTS page
↑ Fagarasanu, A et al. (2006) The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces cerevisiae. Dev. Cell 10 587-600 PubMed GONUTS page
↑ Hoepfner, D et al. (2001) A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae. J. Cell Biol. 155 979-90 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Lillie, SH & Brown, SS (1994) Immunofluorescence localization of the unconventional myosin, Myo2p, and the putative kinesin-related protein, Smy1p, to the same regions of polarized growth in Saccharomyces cerevisiae. J. Cell Biol. 125 825-42 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Pruyne, DW et al. (1998) Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeast. J. Cell Biol. 143 1931-45 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Wagner, W et al. (2002) Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p. EMBO J. 21 6397-408 PubMed GONUTS page
↑ Donovan, KW & Bretscher, A (2012) Myosin-V is activated by binding secretory cargo and released in coordination with Rab/exocyst function. Dev. Cell 23 769-81 PubMed GONUTS page
↑ Schott, D et al. (1999) The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targeting. J. Cell Biol. 147 791-808 PubMed GONUTS page
↑ Brockerhoff, SE et al. (1994) The unconventional myosin, Myo2p, is a calmodulin target at sites of cell growth in Saccharomyces cerevisiae. J. Cell Biol. 124 315-23 PubMed GONUTS page
↑ ^15.0 ^15.1 Hill, KL et al. (1996) Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae. J. Cell Biol. 135 1535-49 PubMed GONUTS page
↑ ^16.0 ^16.1 Yin, H et al. (2000) Myosin V orientates the mitotic spindle in yeast. Nature 406 1013-5 PubMed GONUTS page
↑ ^17.0 ^17.1 Itoh, T et al. (2004) Mmr1p is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast. EMBO J. 23 2520-30 PubMed GONUTS page
↑ ^18.0 ^18.1 Itoh, T et al. (2002) Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae. Mol. Cell. Biol. 22 7744-57 PubMed GONUTS page

[PMID:2016335-1] 1.0 ^1.1 ^1.2 Johnston, GC et al. (1991) The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles. J. Cell Biol. 113 539-51 PubMed GONUTS page

[PMID:19053807-2] Narayanaswamy, R et al. (2009) Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast. J. Proteome Res. 8 6-19 PubMed GONUTS page

[PMID:27307583-3] Lwin, KM et al. (2016) Kinesin-related Smy1 enhances the Rab-dependent association of myosin-V with secretory cargo. Mol. Biol. Cell 27 2450-62 PubMed GONUTS page

[PMID:12594460-4] 4.0 ^4.1 ^4.2 Tang, F et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422 87-92 PubMed GONUTS page

[PMID:11381095-5] 5.0 ^5.1 ^5.2 Reck-Peterson, SL et al. (2001) The yeast class V myosins, Myo2p and Myo4p, are nonprocessive actin-based motors. J. Cell Biol. 153 1121-6 PubMed GONUTS page

[PMID:11285273-6] Rossanese, OW et al. (2001) A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae. J. Cell Biol. 153 47-62 PubMed GONUTS page

[PMID:16678774-7] Fagarasanu, A et al. (2006) The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces cerevisiae. Dev. Cell 10 587-600 PubMed GONUTS page

[PMID:11733545-8] Hoepfner, D et al. (2001) A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae. J. Cell Biol. 155 979-90 PubMed GONUTS page

[PMID:8188749-9] 9.0 ^9.1 ^9.2 ^9.3 Lillie, SH & Brown, SS (1994) Immunofluorescence localization of the unconventional myosin, Myo2p, and the putative kinesin-related protein, Smy1p, to the same regions of polarized growth in Saccharomyces cerevisiae. J. Cell Biol. 125 825-42 PubMed GONUTS page

[PMID:9864365-10] 10.0 ^10.1 ^10.2 ^10.3 Pruyne, DW et al. (1998) Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeast. J. Cell Biol. 143 1931-45 PubMed GONUTS page

[PMID:12456647-11] 11.0 ^11.1 ^11.2 Wagner, W et al. (2002) Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p. EMBO J. 21 6397-408 PubMed GONUTS page

[PMID:23079598-12] Donovan, KW & Bretscher, A (2012) Myosin-V is activated by binding secretory cargo and released in coordination with Rab/exocyst function. Dev. Cell 23 769-81 PubMed GONUTS page

[PMID:10562281-13] Schott, D et al. (1999) The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targeting. J. Cell Biol. 147 791-808 PubMed GONUTS page

[PMID:8294515-14] Brockerhoff, SE et al. (1994) The unconventional myosin, Myo2p, is a calmodulin target at sites of cell growth in Saccharomyces cerevisiae. J. Cell Biol. 124 315-23 PubMed GONUTS page

[PMID:8978821-15] 15.0 ^15.1 Hill, KL et al. (1996) Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae. J. Cell Biol. 135 1535-49 PubMed GONUTS page

[PMID:10984058-16] 16.0 ^16.1 Yin, H et al. (2000) Myosin V orientates the mitotic spindle in yeast. Nature 406 1013-5 PubMed GONUTS page

[PMID:15201867-17] 17.0 ^17.1 Itoh, T et al. (2004) Mmr1p is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast. EMBO J. 23 2520-30 PubMed GONUTS page

[PMID:12391144-18] 18.0 ^18.1 Itoh, T et al. (2002) Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae. Mol. Cell. Biol. 22 7744-57 PubMed GONUTS page

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YEAST:MYO2

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