GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:10984058
| Citation |
Yin, H, Pruyne, D, Huffaker, TC and Bretscher, A (2000) Myosin V orientates the mitotic spindle in yeast. Nature 406:1013-5 |
|---|---|
| Abstract |
Coordination of spindle orientation with the axis of cell division is an essential process in all eukaryotes. In addition to ensuring accurate chromosomal segregation, proper spindle orientation also establishes differential cell fates and proper morphogenesis. In both animal and yeast cells, this process is dependent on cytoplasmic microtubules interacting with the cortical actin-based cytoskeleton, although the motive force was unknown. Here we show that yeast Myo2, a myosin V that translocates along polarized actin cables into the bud, orientates the spindle early in the cell cycle by binding and polarizing the microtubule-associated protein Kar9 (refs 7-9). The tail domain of Myo2 that binds Kar9 also interacts with secretory vesicles and vacuolar elements, making it a pivotal component of yeast cell polarization. |
| Links |
PubMed Online version:10.1038/35023024 |
| Keywords |
Actins/metabolism; Carrier Proteins/metabolism; Carrier Proteins/physiology; Cell Cycle; Microtubule-Associated Proteins/metabolism; Microtubules/metabolism; Mitotic Spindle Apparatus/physiology; Myosin Heavy Chains; Myosin Type II; Myosin Type V; Myosins/metabolism; Myosins/physiology; Nuclear Proteins/metabolism; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae Proteins; Saccharomycetales; Schizosaccharomyces pombe Proteins; Two-Hybrid System Techniques |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
