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YEAST:MET4

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) MET4
Protein Name(s) Transcriptional activator of sulfur metabolism MET4

Methionine-requiring protein 4

External Links
UniProt P32389
EMBL M84455
Z12126
Z50161
Z71379
BK006947
PIR S63043
RefSeq NP_014296.4
ProteinModelPortal P32389
SMR P32389
BioGrid 35720
DIP DIP-2241N
IntAct P32389
MINT MINT-438010
STRING 4932.YNL103W
MaxQB P32389
PaxDb P32389
PeptideAtlas P32389
GeneID 855620
KEGG sce:YNL103W
SGD S000005047
eggNOG NOG41133
InParanoid P32389
OrthoDB EOG7M98V6
BioCyc YEAST:G3O-33131-MONOMER
NextBio 979810
Proteomes UP000002311
Genevestigator P32389
GO GO:0005634
GO:0043565
GO:0003700
GO:0003713
GO:0019344
GO:0009086
GO:0045944
GO:0046685
GO:0046686
GO:0000096
GO:0006351
InterPro IPR004827
SMART SM00338

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0089713

Cbf1-Met4-Met28 complex

PMID:9171357[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0089713

Cbf1-Met4-Met28 complex

PMID:8665859[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046686

response to cadmium ion

PMID:15689486[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046685

response to arsenic-containing substance

PMID:15689486[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:22696683[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9799240[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9799240[5]

ECO:0000353

physical interaction evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:9799240[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000096

sulfur amino acid metabolic process

PMID:1549123[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009086

methionine biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0486

P

Seeded From UniProt

complete

involved_in

GO:0019344

cysteine biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0198

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0008652

cellular amino acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0028

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Kuras, L et al. (1997) Assembly of a bZIP-bHLH transcription activation complex: formation of the yeast Cbf1-Met4-Met28 complex is regulated through Met28 stimulation of Cbf1 DNA binding. EMBO J. 16 2441-51 PubMed GONUTS page
  2. Kuras, L et al. (1996) A heteromeric complex containing the centromere binding factor 1 and two basic leucine zipper factors, Met4 and Met28, mediates the transcription activation of yeast sulfur metabolism. EMBO J. 15 2519-29 PubMed GONUTS page
  3. 3.0 3.1 Yen, JL et al. (2005) The yeast ubiquitin ligase SCFMet30 regulates heavy metal response. Mol. Biol. Cell 16 1872-82 PubMed GONUTS page
  4. McIsaac, RS et al. (2012) Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway. Mol. Biol. Cell 23 2993-3007 PubMed GONUTS page
  5. 5.0 5.1 5.2 Blaiseau, PL & Thomas, D (1998) Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA. EMBO J. 17 6327-36 PubMed GONUTS page
  6. Thomas, D et al. (1992) MET4, a leucine zipper protein, and centromere-binding factor 1 are both required for transcriptional activation of sulfur metabolism in Saccharomyces cerevisiae. Mol. Cell. Biol. 12 1719-27 PubMed GONUTS page