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YEAST:LOT6

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) LOT6
Protein Name(s) NAD(P)H-dependent FMN reductase LOT6

FMN reductase LOT6 Azoreductase LOT6 FMN reductase [NAD(P)H] Low temperature response protein 6

External Links
UniProt Q07923
EMBL Z73183
AY558199
BK006945
PIR S64833
RefSeq NP_013111.1
PDB 1T0I
PDBsum 1T0I
ProteinModelPortal Q07923
SMR Q07923
BioGrid 31285
DIP DIP-4604N
IntAct Q07923
MINT MINT-568995
STRING 4932.YLR011W
MaxQB Q07923
PaxDb Q07923
EnsemblFungi [example_ID YLR011W]
GeneID 850698
KEGG sce:YLR011W
CYGD YLR011w
SGD S000004001
eggNOG COG0431
HOGENOM HOG000263121
InParanoid Q07923
OMA NWSIPAS
OrthoDB EOG7D5B08
BioCyc YEAST:G3O-32172-MONOMER
EvolutionaryTrace Q07923
NextBio 966730
Proteomes UP000002311
Genevestigator Q07923
GO GO:0005829
GO:0005634
GO:0052874
GO:0052873
GO:0003955
GO:0008134
GO:0006915
GO:0034599
GO:0042994
Gene3D 3.40.50.360
InterPro IPR029039
IPR005025
Pfam PF03358
SUPFAM SSF52218

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005634

nucleus

PMID:14562095[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:14562095[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042994

cytoplasmic sequestering of transcription factor

PMID:19029946[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

PMID:17298444[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:19029946[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:19709309[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:17298444[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17298444[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003955

NAD(P)H dehydrogenase (quinone) activity

PMID:17298444[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003955

NAD(P)H dehydrogenase (quinone) activity

PMID:17298444[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0052873

FMN reductase (NADPH) activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001254275
UniProtKB:Q9I4D4

F

Seeded From UniProt

complete

enables

GO:0010181

FMN binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11723
PANTHER:PTN001254275
UniProtKB:Q9I4D4

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11723
PANTHER:PTN001254275
SGD:S000004001
TAIR:locus:2086445

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005025

F

Seeded From UniProt

complete

enables

GO:0052874

FMN reductase (NADH) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.5.1.39

F

Seeded From UniProt

complete

enables

GO:0052873

FMN reductase (NADPH) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.5.1.39

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
  2. 2.0 2.1 Sollner, S et al. (2009) Quinone reductase acts as a redox switch of the 20S yeast proteasome. EMBO Rep. 10 65-70 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Sollner, S et al. (2007) Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification. FEBS J. 274 1328-39 PubMed GONUTS page
  4. Sollner, S et al. (2009) The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis. FEMS Yeast Res. 9 885-91 PubMed GONUTS page
  5. 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page