YEAST:HXKB

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	HXK2 (synonyms: HEX1, HKB)
Protein Name(s)	Hexokinase-2 Hexokinase PII Hexokinase-B
External Links
UniProt	P04807
EMBL	X03483 M11181 M14411 X94357 Z72775 X67787 BK006941
PIR	S61608
RefSeq	NP_011261.1
PDB	1IG8 2YHX
PDBsum	1IG8 2YHX
ProteinModelPortal	P04807
SMR	P04807
BioGrid	33026
DIP	DIP-2380N
IntAct	P04807
MINT	MINT-2784874
STRING	4932.YGL253W
SWISS-2DPAGE	P04807
MaxQB	P04807
PaxDb	P04807
PeptideAtlas	P04807
EnsemblFungi	[example_ID YGL253W]
GeneID	852639
KEGG	sce:YGL253W
SGD	S000003222
eggNOG	COG5026
GeneTree	ENSGT00390000017159
HOGENOM	HOG000162670
InParanoid	P04807
KO	K00844
OMA	AIAIDGC
OrthoDB	EOG79SF68
BioCyc	YEAST:YGL253W-MONOMER
BRENDA	2.7.1.1
Reactome	REACT_237953 REACT_253318 REACT_260359
SABIO-RK	P04807
UniPathway	UPA00242
EvolutionaryTrace	P04807
NextBio	971888
PRO	PR:P04807
Proteomes	UP000002311
Genevestigator	P04807
GO	GO:0005829 GO:0005739 GO:0005634 GO:0005524 GO:0004396 GO:0046835 GO:0032445 GO:0006000 GO:0046323 GO:0006006 GO:0006096 GO:0006013 GO:0046015 GO:0001302
InterPro	IPR001312 IPR022673 IPR019807 IPR022672
PANTHER	PTHR19443
Pfam	PF00349 PF03727
PRINTS	PR00475
PROSITE	PS00378

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005739	mitochondrion	PMID:24769239^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008361	regulation of cell size	PMID:12089449^[2]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046323	glucose import	PMID:6300872^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000545 SGD:S000001949	P	Seeded From UniProt	complete
involved_in	GO:0046015	regulation of transcription by glucose	PMID:11311123^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032445	fructose import	PMID:6300872^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000001949	P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:8917466^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:8917466^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:332086^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006013	mannose metabolic process	PMID:332086^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	PMID:6300872^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006000	fructose metabolic process	PMID:6300872^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:9563516^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11311123^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:16962558^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11311123^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9563516^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	PMID:6341351^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	PMID:332086^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	PMID:12611889^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001302	replicative cell aging	PMID:15722108^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019158	mannokinase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c	F	Seeded From UniProt	complete
enables	GO:0008865	fructokinase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c TAIR:locus:2008031 TAIR:locus:2087590 TAIR:locus:2119931 TAIR:locus:2137564 TAIR:locus:2202410 UniProtKB:P93834 UniProtKB:Q4WHC3	F	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 RGD:2670 RGD:2796 SGD:S000000545 SGD:S000001949 SGD:S000003222	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 MGI:MGI:96103 PANTHER:PTN000455350 RGD:2670 RGD:2796 SGD:S000003222 UniProtKB:C6KT76 UniProtKB:P35557	C	Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 MGI:MGI:96103 PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c RGD:2670 RGD:2796 SGD:S000000545 TAIR:locus:2008031 TAIR:locus:2087590 TAIR:locus:2119931 TAIR:locus:2137564 TAIR:locus:2202410 UniProtKB:P35557 UniProtKB:P93834 UniProtKB:Q4WCS2 UniProtKB:Q4WHC3 UniProtKB:Q5W676 UniProtKB:Q8LQ68	F	Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 PANTHER:PTN000455350 RGD:2670	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004396	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004396	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004396	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004396	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019158	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008865	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004396	P	Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004340	P	Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312	P	Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807 InterPro:IPR022672 InterPro:IPR022673	F	Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312	F	Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR022672 InterPro:IPR022673	P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019807	P	Seeded From UniProt	complete
enables	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022672 InterPro:IPR022673	F	Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.1	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324	P	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0019318	hexose metabolic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00242	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Renvoisé, M et al. (2014) Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae. J Proteomics 106 140-50 PubMed GONUTS page
↑ Jorgensen, P et al. (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297 395-400 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Bisson, LF & Fraenkel, DG (1983) Involvement of kinases in glucose and fructose uptake by Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 80 1730-4 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Rodríguez, A et al. (2001) The hexokinase 2 protein regulates the expression of the GLK1, HXK1 and HXK2 genes of Saccharomyces cerevisiae. Biochem. J. 355 625-31 PubMed GONUTS page
↑ ^5.0 ^5.1 De Winde, JH et al. (1996) Differential requirement of the yeast sugar kinases for sugar sensing in establishing the catabolite-repressed state. Eur. J. Biochem. 241 633-43 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Lobo, Z & Maitra, PK (1977) Physiological role of glucose-phosphorylating enzymes in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 182 639-45 PubMed GONUTS page
↑ ^7.0 ^7.1 Randez-Gil, F et al. (1998) Hexokinase PII has a double cytosolic-nuclear localisation in Saccharomyces cerevisiae. FEBS Lett. 425 475-8 PubMed GONUTS page
↑ Brandina, I et al. () Enolase takes part in a macromolecular complex associated to mitochondria in yeast. Biochim. Biophys. Acta 1757 1217-28 PubMed GONUTS page
↑ Walsh, RB et al. (1983) Cloning of genes that complement yeast hexokinase and glucokinase mutants. J. Bacteriol. 154 1002-4 PubMed GONUTS page
↑ Bianconi, ML (2003) Calorimetric determination of thermodynamic parameters of reaction reveals different enthalpic compensations of the yeast hexokinase isozymes. J. Biol. Chem. 278 18709-13 PubMed GONUTS page
↑ Kaeberlein, M et al. (2005) Genes determining yeast replicative life span in a long-lived genetic background. Mech. Ageing Dev. 126 491-504 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24769239-1] Renvoisé, M et al. (2014) Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae. J Proteomics 106 140-50 PubMed GONUTS page

[PMID:12089449-2] Jorgensen, P et al. (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297 395-400 PubMed GONUTS page

[PMID:6300872-3] 3.0 ^3.1 ^3.2 ^3.3 Bisson, LF & Fraenkel, DG (1983) Involvement of kinases in glucose and fructose uptake by Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 80 1730-4 PubMed GONUTS page

[PMID:11311123-4] 4.0 ^4.1 ^4.2 Rodríguez, A et al. (2001) The hexokinase 2 protein regulates the expression of the GLK1, HXK1 and HXK2 genes of Saccharomyces cerevisiae. Biochem. J. 355 625-31 PubMed GONUTS page

[PMID:8917466-5] 5.0 ^5.1 De Winde, JH et al. (1996) Differential requirement of the yeast sugar kinases for sugar sensing in establishing the catabolite-repressed state. Eur. J. Biochem. 241 633-43 PubMed GONUTS page

[PMID:332086-6] 6.0 ^6.1 ^6.2 Lobo, Z & Maitra, PK (1977) Physiological role of glucose-phosphorylating enzymes in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 182 639-45 PubMed GONUTS page

[PMID:9563516-7] 7.0 ^7.1 Randez-Gil, F et al. (1998) Hexokinase PII has a double cytosolic-nuclear localisation in Saccharomyces cerevisiae. FEBS Lett. 425 475-8 PubMed GONUTS page

[PMID:16962558-8] Brandina, I et al. () Enolase takes part in a macromolecular complex associated to mitochondria in yeast. Biochim. Biophys. Acta 1757 1217-28 PubMed GONUTS page

[PMID:6341351-9] Walsh, RB et al. (1983) Cloning of genes that complement yeast hexokinase and glucokinase mutants. J. Bacteriol. 154 1002-4 PubMed GONUTS page

[PMID:12611889-10] Bianconi, ML (2003) Calorimetric determination of thermodynamic parameters of reaction reveals different enthalpic compensations of the yeast hexokinase isozymes. J. Biol. Chem. 278 18709-13 PubMed GONUTS page

[PMID:15722108-11] Kaeberlein, M et al. (2005) Genes determining yeast replicative life span in a long-lived genetic background. Mech. Ageing Dev. 126 491-504 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:HXKB

Contents

Annotations

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References

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