PMID:12089449

Citation	Jorgensen, P, Nishikawa, JL, Breitkreutz, BJ and Tyers, M (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297:395-400
Abstract	Size homeostasis in budding yeast requires that cells grow to a critical size before commitment to division in the late prereplicative growth phase of the cell cycle, an event termed Start. We determined cell size distributions for the complete set of approximately 6000 Saccharomyces cerevisiae gene deletion strains and identified approximately 500 abnormally small (whi) or large (lge) mutants. Genetic analysis revealed a complex network of newly found factors that govern critical cell size at Start, the most potent of which were Sfp1, Sch9, Cdh1, Prs3, and Whi5. Ribosome biogenesis is intimately linked to cell size through Sfp1, a transcription factor that controls the expression of at least 60 genes implicated in ribosome assembly. Cell growth and division appear to be coupled by multiple conserved mechanisms.
Links	PubMed Online version:10.1126/science.1070850
Keywords	Cell Cycle; Cell Division; Cell Nucleolus/metabolism; Crosses, Genetic; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Epistasis, Genetic; Gene Deletion; Gene Expression Regulation, Fungal; Genes, Essential; Genes, Fungal; Mutation; Oligonucleotide Array Sequence Analysis; Oxygen Consumption; Phenotype; Protein Kinases/genetics; Protein Kinases/physiology; Ribosomes/metabolism; Saccharomyces cerevisiae/cytology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/growth & development; Saccharomyces cerevisiae/physiology; Saccharomyces cerevisiae/ultrastructure; Saccharomyces cerevisiae Proteins/biosynthesis; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/physiology
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