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YEAST:FOB1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) FOB1 (ECO:0000303 with PMID:9078378[1]) (synonyms: HRM1 (ECO:0000303 with PMID:10230397[2]))
Protein Name(s) DNA replication fork-blocking protein FOB1 (ECO:0000303 with PMID:9078378[1])
External Links
UniProt O13329
EMBL AF013245
Z48758
BK006938
PIR S52676
RefSeq NP_010395.1
ProteinModelPortal O13329
BioGrid 32168
DIP DIP-870N
IntAct O13329
MINT MINT-407409
STRING 4932.YDR110W
MaxQB O13329
PaxDb O13329
PeptideAtlas O13329
EnsemblFungi [example_ID YDR110W]
GeneID 851688
KEGG sce:YDR110W
SGD S000002517
eggNOG NOG44059
InParanoid O13329
KO K12577
OrthoDB EOG73NGDF
BioCyc YEAST:G3O-29712-MONOMER
NextBio 969338
Proteomes UP000002311
Genevestigator O13329
GO GO:0005730
GO:0033553
GO:0043110
GO:0000183
GO:0007059
GO:0006310
GO:0007580
GO:0043007
GO:0008156
GO:0034503
GO:0070550
GO:0001302

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007580

extrachromosomal circular DNA accumulation involved in cell aging

PMID:10521401[3]

ECO:0000315

P

Figure 4.Accumulation of ERCs occurs more rapidly in a sir2 mutant than in wild-type mother cells when the cell is FOB1 dependent.Mutation of fob1 in sir2D hmlD mother cells decreases ERC accumulation below levels observed in wild-type cells.

complete

GO:0007569

cell aging

PMID:10521401[3]

ECO:0000315

P

Figure 6.shows that Mutation of fob1 suppresses the life span defect of a sir2 mutant.

complete

involved_in

GO:0045911

positive regulation of DNA recombination

PMID:25822194[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090342

regulation of cell aging

PMID:25822194[4]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000004500

P

Seeded From UniProt

complete

involved_in

GO:0090342

regulation of cell aging

PMID:25822194[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070550

rDNA condensation

PMID:18923139[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007059

chromosome segregation

PMID:16769819[6]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000001924

P

Seeded From UniProt

complete

enables

GO:0043110

rDNA spacer replication fork barrier binding

PMID:14645529[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043007

maintenance of rDNA

PMID:23593017[8]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000003925

P

Seeded From UniProt

complete

involved_in

GO:0034503

protein localization to nucleolar rDNA repeats

PMID:19362534[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0033553

rDNA heterochromatin

PMID:22362748[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008156

negative regulation of DNA replication

PMID:14645529[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007580

extrachromosomal circular DNA accumulation involved in cell aging

PMID:10230397[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

PMID:9078378[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:10230397[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001302

replicative cell aging

PMID:15722108[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000183

chromatin silencing at rDNA

PMID:12923057[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043110

rDNA spacer replication fork barrier binding

PMID:26951198[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000183

chromatin silencing at rDNA

PMID:26951198[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031582

replication fork arrest at rDNA repeats

PMID:26951198[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

PMID:26951198[13]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000002200

P

Seeded From UniProt

complete

involved_in

GO:0090579

dsDNA loop formation

PMID:26951198[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0233

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0235

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Kobayashi, T & Horiuchi, T (1996) A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities. Genes Cells 1 465-74 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Defossez, PA et al. (1999) Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol. Cell 3 447-55 PubMed GONUTS page
  3. ↑ 3.0 3.1 Kaeberlein, M et al. (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13 2570-80 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Peng, J et al. (2015) Inhibition of telomere recombination by inactivation of KEOPS subunit Cgi121 promotes cell longevity. PLoS Genet. 11 e1005071 PubMed GONUTS page
  5. ↑ Waples, WG et al. (2009) Putting the brake on FEAR: Tof2 promotes the biphasic release of Cdc14 phosphatase during mitotic exit. Mol. Biol. Cell 20 245-55 PubMed GONUTS page
  6. ↑ Machín, F et al. (2006) Transcription of ribosomal genes can cause nondisjunction. J. Cell Biol. 173 893-903 PubMed GONUTS page
  7. ↑ 7.0 7.1 Kobayashi, T (2003) The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork. Mol. Cell. Biol. 23 9178-88 PubMed GONUTS page
  8. ↑ Ide, S et al. (2013) Rtt109 prevents hyper-amplification of ribosomal RNA genes through histone modification in budding yeast. PLoS Genet. 9 e1003410 PubMed GONUTS page
  9. ↑ Johzuka, K & Horiuchi, T (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol. Cell 34 26-35 PubMed GONUTS page
  10. ↑ Ha, CW et al. (2012) Nsi1 plays a significant role in the silencing of ribosomal DNA in Saccharomyces cerevisiae. Nucleic Acids Res. 40 4892-903 PubMed GONUTS page
  11. ↑ Kaeberlein, M et al. (2005) Genes determining yeast replicative life span in a long-lived genetic background. Mech. Ageing Dev. 126 491-504 PubMed GONUTS page
  12. ↑ Huang, J & Moazed, D (2003) Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing. Genes Dev. 17 2162-76 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 13.3 13.4 Zaman, S et al. (2016) Mechanism of Regulation of Intrachromatid Recombination and Long-Range Chromosome Interactions in Saccharomyces cerevisiae. Mol. Cell. Biol. 36 1451-63 PubMed GONUTS page
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