XENLA:EXO1

Species (Taxon ID)	Xenopus laevis (African clawed frog). (8355)
Gene Name(s)	exo1 (synonyms: exoi)
Protein Name(s)	Exonuclease 1 Exonuclease I
External Links
UniProt	Q9W6K2
EMBL	AF134570 BC084102
RefSeq	NP_001083827.1
UniGene	Xl.489
ProteinModelPortal	Q9W6K2
GeneID	399140
KEGG	xla:399140
CTD	9156
Xenbase	XB-GENE-982081
HOVERGEN	HBG081488
KO	K10746
GO	GO:0005634 GO:0003677 GO:0048256 GO:0046872 GO:0045145 GO:0000737 GO:0000738 GO:0006310 GO:0006298
Gene3D	3.40.50.1010
InterPro	IPR020045 IPR008918 IPR029060 IPR006086 IPR019974 IPR006085
Pfam	PF00867 PF00752
SMART	SM00279 SM00484 SM00485
SUPFAM	SSF47807 SSF88723
PROSITE	PS00841 PS00842

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0051908	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity	PMID:21490081	ECO:0000315			F		Fig 2. Wild-type xEXO1, but not mutant xEXO1 displayed strong activity towards the 5′ dsDNA. After 1 h of incubation at room temperature, the substrate was almost completely degraded.	complete
	GO:0000729	DNA double-strand break processing	PMID:21490081	ECO:0000315			P		Fig 3. In xEXO1-depleted cytosol, DNA degradation was inhibited significantly. This effect was reversed by the addition of the wild-type recombinant xEXO1 protein.	complete
enables	GO:0048256	flap endonuclease activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UQ84	F		Seeded From UniProt	complete
enables	GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UQ84	F		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UQ84	P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UQ84	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UQ84	C		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0045145	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0035312	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004527	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008918 InterPro:IPR037315	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008918	F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006084 InterPro:IPR006085 InterPro:IPR006086	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006084 InterPro:IPR006085 InterPro:IPR032641	P		Seeded From UniProt	complete
enables	GO:0016788	hydrolase activity, acting on ester bonds	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019974	F		Seeded From UniProt	complete
enables	GO:0035312	5'-3' exodeoxyribonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032641 InterPro:IPR037315	F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0267 UniProtKB-KW:KW-0540	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0228 UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt	complete
enables	GO:0004527	exonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0269	F		Seeded From UniProt	complete
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References

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