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XENLA:CHFR
Contents
Species (Taxon ID) | Xenopus laevis (African clawed frog). (8355) | |
Gene Name(s) | chfr | |
Protein Name(s) | E3 ubiquitin-protein ligase CHFR
Checkpoint with forkhead and RING finger domains protein | |
External Links | ||
UniProt | Q5FWP4 | |
EMBL | BC089260 | |
RefSeq | NP_001089240.1 | |
UniGene | Xl.25667 | |
ProteinModelPortal | Q5FWP4 | |
SMR | Q5FWP4 | |
BioGrid | 592068 | |
IntAct | Q5FWP4 | |
GeneID | 734287 | |
KEGG | xla:734287 | |
CTD | 55743 | |
Xenbase | XB-GENE-6251657 | |
KO | K10644 | |
UniPathway | UPA00143 | |
GO | GO:0005634 GO:0016605 GO:0016874 GO:0000166 GO:0004842 GO:0008270 GO:0007093 GO:0007067 GO:0019941 GO:0000209 | |
Gene3D | 2.60.200.20 3.30.40.10 | |
InterPro | IPR000253 IPR008984 IPR001841 IPR013083 IPR017907 | |
Pfam | PF00498 PF13639 | |
SMART | SM00240 SM00184 | |
SUPFAM | SSF49879 | |
PROSITE | PS50006 PS00518 PS50089 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0051437 |
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition |
ECO:0000314 |
P |
Figures 5 and 6 |
complete | |||||
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000314 |
F |
Figure 6 |
complete | |||||
involved_in |
GO:0019941 |
modification-dependent protein catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016605 |
PML body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007093 |
mitotic cell cycle checkpoint |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051301 |
cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016605 |
PML body |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kang, D et al. (2002) The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. J. Cell Biol. 156 249-59 PubMed GONUTS page
- ↑ Daniels, MJ et al. (2004) PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein. Nat. Struct. Mol. Biol. 11 1114-21 PubMed GONUTS page
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