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XENLA:CHFR

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Species (Taxon ID) Xenopus laevis (African clawed frog). (8355)
Gene Name(s) chfr
Protein Name(s) E3 ubiquitin-protein ligase CHFR

Checkpoint with forkhead and RING finger domains protein

External Links
UniProt Q5FWP4
EMBL BC089260
RefSeq NP_001089240.1
UniGene Xl.25667
ProteinModelPortal Q5FWP4
SMR Q5FWP4
BioGrid 592068
IntAct Q5FWP4
GeneID 734287
KEGG xla:734287
CTD 55743
Xenbase XB-GENE-6251657
KO K10644
UniPathway UPA00143
GO GO:0005634
GO:0016605
GO:0016874
GO:0000166
GO:0004842
GO:0008270
GO:0007093
GO:0007067
GO:0019941
GO:0000209
Gene3D 2.60.200.20
3.30.40.10
InterPro IPR000253
IPR008984
IPR001841
IPR013083
IPR017907
Pfam PF00498
PF13639
SMART SM00240
SM00184
SUPFAM SSF49879
PROSITE PS50006
PS00518
PS50089

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051437

positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition

PMID:11807090[1]

ECO:0000314

P

Figures 5 and 6

complete
CACAO 10552

GO:0061630

ubiquitin protein ligase activity

PMID:11807090[1]

ECO:0000314

F

Figure 6

complete
CACAO 10553

involved_in

GO:0019941

modification-dependent protein catabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EP1

P

Seeded From UniProt

complete

part_of

GO:0016605

PML body

PMID:15467728[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EP1

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EP1

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EP1

F

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EP1

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EP1

F

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0465

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Kang, D et al. (2002) The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. J. Cell Biol. 156 249-59 PubMed GONUTS page
  2. Daniels, MJ et al. (2004) PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein. Nat. Struct. Mol. Biol. 11 1114-21 PubMed GONUTS page