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VIBCH:TOXR
Contents
| Species (Taxon ID) | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961). (243277) | |
| Gene Name(s) | toxR | |
| Protein Name(s) | Cholera toxin transcriptional activator | |
| External Links | ||
| UniProt | P15795 | |
| EMBL | M21249 AE003852 M58033 M62761 | |
| PIR | A25970 E82257 | |
| RefSeq | NP_230630.1 | |
| ProteinModelPortal | P15795 | |
| STRING | 243277.VC0984 | |
| DNASU | 2614237 | |
| EnsemblBacteria | AAF94145 | |
| GeneID | 2614237 | |
| KEGG | vch:VC0984 | |
| PATRIC | 20081066 | |
| eggNOG | COG3710 | |
| KO | K10921 | |
| OMA | FVKTVPK | |
| OrthoDB | EOG66XBBC | |
| BioCyc | VCHO:VC0984-MONOMER | |
| Proteomes | UP000000584 | |
| GO | GO:0016021 GO:0005886 GO:0003677 GO:0000156 GO:0009405 GO:0006355 GO:0006351 | |
| Gene3D | 1.10.10.10 | |
| InterPro | IPR001867 IPR016032 IPR011991 | |
| Pfam | PF00486 | |
| SMART | SM00862 | |
| SUPFAM | SSF46894 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:2000145 |
regulation of cell motility |
ECO:0000270 |
P |
Table 1. Top right of page 2805 |
complete | |||||
| GO:0090087 |
regulation of peptide transport |
ECO:0000315 |
P |
Table 1. Top of page 2805 gives more information about specific pathways. |
complete | |||||
| GO:0090087 |
regulation of peptide transport |
ECO:0000270 |
P |
Table 1. Top of page 2805 gives more information about specific pathways. |
complete | |||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
ECO:0000315 |
P |
Figure 5: ToxR regulates leuO expression |
complete | |||||
| GO:0010675 |
regulation of cellular carbohydrate metabolic process |
ECO:0000315 |
P |
Table 1. Top right of page 2805. |
complete | |||||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0010675 |
regulation of cellular carbohydrate metabolic process |
ECO:0000270 |
P |
Table 1. Top right of page 2805. |
complete | |||||
|
enables |
GO:0000156 |
phosphorelay response regulator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0000156 |
two-component response regulator activity |
ECO:0000314 |
F |
figure 1, This suggests the ToxR-V71A mutation affects a region of ToxR that is especially important for ToxR to directly activate the ompU promoter, but less critical when ToxR plays an accessory role with TcpP to activate the toxT promoter figure 3. Gel-shift assays to assess promoter recognition by various ToxR mutant proteins identified in a random mutagenesis ompU-sacB selection strategy. |
complete | |||||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0000160 |
phosphorelay signal transduction system |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000160 |
phosphorelay signal transduction system |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Bina, J et al. (2003) ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients. Proc. Natl. Acad. Sci. U.S.A. 100 2801-6 PubMed GONUTS page
- ↑ 2.0 2.1 Bina, XR et al. (2013) Vibrio cholerae ToxR downregulates virulence factor production in response to cyclo(Phe-Pro). MBio 4 e00366-13 PubMed GONUTS page
- ↑ 3.0 3.1 Morgan, SJ et al. (2011) The two faces of ToxR: activator of ompU, co-regulator of toxT in Vibrio cholerae. Mol. Microbiol. 81 113-28 PubMed GONUTS page
- ↑ 4.0 4.1 Heidelberg, JF et al. (2000) DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature 406 477-83 PubMed GONUTS page
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