User:Zgeeraerts

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
unacceptable	HELHP:Q7VJL9	2014-03-01 16:21:35 CST	GO:0046677 response to antibiotic (P)	PMID:19191900	ECO:0000315 mutant phenotype evidence used in manual assertion	Table 3 shows that the minimal inhibitory concentration (MIC) of amoxicillin is higher in bacteria that contain HefA than the mutant bacteria without HefA. This suggests that HefA contributes to amoxicillin resistance.	challenge
unacceptable	HELHP:Q7VJL9	2014-03-21 20:19:01 CDT	GO:0006810 transport (P)	PMID:19191900	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 1 shows the genes used to identify RND efflux pumps in H. hepaticus which are highly homologous in other bacteria. Table 3 shows the minimal inhibitory concentration (MIC) of various compounds with wild-type and mutant HefA. The mutant HefA resulted in a significant drop in MIC for amoxicillin and bile acids. These data support that HefA is a multi-drug efflux pump which transports toxic compounds outside of the cell.	challenge

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unacceptable:2
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Annotations challenged by Zgeeraerts

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

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