HELHP:Q7VJL9

Species (Taxon ID)	Helicobacter hepaticus (strain ATCC 51449 / 3B1). (235279)
Gene Name(s)	No Information Provided.
Protein Name(s)	Uncharacterized protein (ECO:0000313 with EMBL:AAP76821.1)
External Links
UniProt	Q7VJL9
EMBL	AE017125
RefSeq	NP_859755.1 WP_011115068.1
ProteinModelPortal	Q7VJL9
STRING	235279.HH0224
EnsemblBacteria	AAP76821
GeneID	1493279
KEGG	hhe:HH0224
PATRIC	20587868
OMA	VDFTTYL
OrthoDB	EOG6GFGFR
BioCyc	HHEP235279:GHUA-231-MONOMER
Proteomes	UP000002495
GO	GO:0005215
InterPro	IPR003423
Pfam	PF02321

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0046677	response to antibiotic	PMID:19191900	ECO:0000315			P		Table 3 shows that the minimal inhibitory concentration (MIC) of amoxicillin is higher in bacteria that contain HefA than the mutant bacteria without HefA. This suggests that HefA contributes to amoxicillin resistance.	complete CACAO 9578
	GO:0006810	transport	PMID:19191900	ECO:0000315			P		Figure 1 shows the genes used to identify RND efflux pumps in H. hepaticus which are highly homologous in other bacteria. Table 3 shows the minimal inhibitory concentration (MIC) of various compounds with wild-type and mutant HefA. The mutant HefA resulted in a significant drop in MIC for amoxicillin and bile acids. These data support that HefA is a multi-drug efflux pump which transports toxic compounds outside of the cell.	complete CACAO 9629
enables	GO:0015562	efflux transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003423	F		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003423	P		Seeded From UniProt	complete
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References

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