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PMID:19191900
| Citation |
Belzer, C, Stoof, J, Breijer, S, Kusters, JG, Kuipers, EJ and van Vliet, AH (2009) The Helicobacter hepaticus hefA gene is involved in resistance to amoxicillin. Helicobacter 14:72-9 |
|---|---|
| Abstract |
Gastrointestinal infections with pathogenic Helicobacter species are commonly treated with combination therapies, which often include amoxicillin. Although this treatment is effective for eradication of Helicobacter pylori, the few existing reports are less clear about antibiotic susceptibility of other Helicobacter species. In this study we have determined the susceptibility of gastric and enterohepatic Helicobacter species to amoxicillin, and have investigated the mechanism of amoxicillin resistance in Helicobacter hepaticus. |
| Links |
PubMed Online version:10.1111/j.1523-5378.2009.00661.x |
| Keywords |
Amoxicillin/pharmacology; Animals; Anti-Bacterial Agents/pharmacology; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Helicobacter hepaticus/drug effects; Helicobacter hepaticus/genetics; Helicobacter hepaticus/metabolism; Humans; Membrane Transport Proteins/genetics; Membrane Transport Proteins/metabolism; Microbial Sensitivity Tests; Mutation |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0046677: response to antibiotic |
ECO:0000315: |
P |
Table 3 shows that the minimal inhibitory concentration (MIC) of amoxicillin is higher in bacteria that contain HefA than the mutant bacteria without HefA. This suggests that HefA contributes to amoxicillin resistance. |
complete | ||||
| GO:0006810: transport |
ECO:0000315: |
P |
Figure 1 shows the genes used to identify RND efflux pumps in H. hepaticus which are highly homologous in other bacteria. Table 3 shows the minimal inhibitory concentration (MIC) of various compounds with wild-type and mutant HefA. The mutant HefA resulted in a significant drop in MIC for amoxicillin and bile acids. These data support that HefA is a multi-drug efflux pump which transports toxic compounds outside of the cell. |
complete | ||||
See also
References
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