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TRYB2:JBP2

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Species (Taxon ID) Trypanosoma brucei brucei (strain 927/4 GUTat10.1). (185431)
Gene Name(s) JBP2
Protein Name(s) Bifunctional helicase and thymine dioxygenase JBP2

J-binding protein 2 TbJBP2 Probable DNA helicase JBP2 Thymine dioxygenase JBP2

External Links
UniProt Q57X81
EMBL AC159421
RefSeq XP_846088.1
ProteinModelPortal Q57X81
GeneID 3658676
KEGG tbr:Tb927.7.4650
eggNOG COG0553
InParanoid Q57X81
OMA NFRTAVH
Proteomes UP000008524
GO GO:0005634
GO:0005524
GO:0003677
GO:0004386
GO:0046872
GO:0050341
GO:0070580
Gene3D 3.40.50.300
InterPro IPR024779
IPR014001
IPR001650
IPR027417
IPR000330
Pfam PF00271
PF00176
PF12851
SMART SM00487
SM00490
SUPFAM SSF52540
PROSITE PS51192
PS51194

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0070580

base J metabolic process

PMID:19136460[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070580

base J metabolic process

PMID:15694344[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050341

thymine dioxygenase activity

PMID:19136460[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19136460[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15694344[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070580

base J metabolic process

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:B6EU02

P

Seeded From UniProt

complete

enables

GO:0050341

thymine dioxygenase activity

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:B6EU02

F

Seeded From UniProt

complete

enables

GO:0008198

ferrous iron binding

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

GeneDB:Tb927.11.13640

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:B6EU02

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000330

F

Seeded From UniProt

complete

enables

GO:0050341

thymine dioxygenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.14.11.6

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0004386

helicase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0347

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0051213

dioxygenase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0223

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Cliffe, LJ et al. (2009) JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes. Nucleic Acids Res. 37 1452-62 PubMed GONUTS page
  2. 2.0 2.1 DiPaolo, C et al. (2005) Regulation of trypanosome DNA glycosylation by a SWI2/SNF2-like protein. Mol. Cell 17 441-51 PubMed GONUTS page