GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| GO:0010628 | positive regulation of gene expression | PMID:22234890 | IDA: Inferred from Direct Assay | P | ||||
| This annotation made on page: HUMAN:A8KAQ8 By: Gandii2 (group Team Protein Titans) on 2014-04-06 10:36:59 CDT. | ||||||||
You must be logged in to challenge this annotation.
| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | Biernate, MichSt14A 26 | 2014-04-11 17:37:53 CDT | Also, the evidence code should probably be changed from IDA to IMP, since two different alleles for the HERC2 gene are being compared to see how SNP rs12913832 affects OCA2. | 0 |
| Challenge | Biernate, MichSt14A 26 | 2014-04-11 16:55:16 CDT | The GO number should be changed to GO:0071733, since SNP rs12913832, since the SNP acts as an enhancer by binding to OCA2 and forming a long-range chromatin loop. The notes should also be changed: Figure 1C shows significantly higher expression of OCA2 in cell lines that have SNP rs12913832 than those that do not have the SNP, and RNA Pol II binding to the OCA2 promoter was higher in cell lines with SNP rs12913832 than those that did not have the SNP. Figure 3 shows high cross-linking frequencies between the OCA2 promoter and SNP rs12913832, indicating loop formation between the two loci. In total, the data suggests that SNP rs12913832 is a positive enhancer of OCA2 by loop formation. | 0 |
| Challenge | Biernate, MichSt14A 26 | 2014-04-11 16:49:27 CDT | The GO number should be changed to GO:0071733, since SNP rs12913832, since the SNP acts as an enhancer by binding to OCA2 and forming a long-range chromatin loop. The notes should also be changed: Figure 1C shows significantly higher expression of OCA2 in cell lines that have SNP rs12913832 than those that do not have the SNP, and RNA Pol II binding to th | 0 |
| Public Assessment | JimHu | 2014-05-02 18:01:38 CDT | Note that there are other accepted annotations to this paper. This paper is not about the function of the HERC2 gene. It shows that a SNP in the HERC2 gene creates an enhancer that regulates expression of OCA2. Regulation of transcription from that enhancer is controlled by other proteins. | Unacceptable |
| Public Assessment | DanielRenfro | 2014-04-11 17:37:53 CDT | This annotation has been flagged because it has been edited since last assessment ||GO:0010628||positive regulation of gene expression||PMID:22234890||IDA: Inferred from Direct Assay||||P||The over-expression of transcription factor HLTF led to an elevated expression of OCA2, which leads to a darker pigmentation (Figure 4B), when bound to the HERC2 region. This is an IDA because the levels of HLTF correlated to a darker pigmentation when bound to HERC2. Therefore, HERC2 positively regulates the expression of the gene for dark pigment. ||complete | Flagged |
| Public Assessment | DanielRenfro | 2014-04-11 16:55:17 CDT | This annotation has been flagged because it has been edited since last assessment ||GO:0010628||positive regulation of gene expression||PMID:22234890||IDA: Inferred from Direct Assay||||P||The over-expression of transcription factor HLTF led to an elevated expression of OCA2, which leads to a darker pigmentation (Figure 4B), when bound to the HERC2 region. This is an IDA because the levels of HLTF correlated to a darker pigmentation when bound to HERC2. Therefore, HERC2 positively regulates the expression of the gene for dark pigment. ||complete | Flagged |
| Public Assessment | DanielRenfro | 2014-04-11 16:49:27 CDT | This annotation has been flagged because it has been edited since last assessment ||GO:0010628||positive regulation of gene expression||PMID:22234890||IDA: Inferred from Direct Assay||||P||The over-expression of transcription factor HLTF led to an elevated expression of OCA2, which leads to a darker pigmentation (Figure 4B), when bound to the HERC2 region. This is an IDA because the levels of HLTF correlated to a darker pigmentation when bound to HERC2. Therefore, HERC2 positively regulates the expression of the gene for dark pigment. ||complete | Flagged |
| Private Assessment | Suzialeksander | 2014-04-09 15:45:03 CDT | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✔ With/From ✗ Notes |
