GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| GO:0045869 | negative regulation of retroviral genome replication | PMID:22554282 | IDA: Inferred from Direct Assay | P | ||||
| This annotation made on page: HUMAN:KPCD By: Kjlawson (group Team The Lab in Back) on 2013-09-26 12:29:27 CDT. | ||||||||
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| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | Roosheel, Team I got Krebs | 2013-11-15 13:16:44 CST | Evidence should be IMP | 2 |
| Challenge | Roosheel, Team I got Krebs | 2013-11-14 23:43:08 CST | Evidence is IDA, as the assay is done using siRNAs with PKC delta. No mutants are used. | 0 |
| Challenge | Roosheel, Team I got Krebs | 2013-11-14 23:42:16 CST | Notes should be 4D, as it shows how siRNA+PKC delta results in the deformation of the actin cytoskeleton, in contrast to 4A and 4B GO term should be GO:0032956: regulation of actin cytoskeleton organization, is the most specific term available. | 3 |
| Challenge | Roosheel, Team I got Krebs | 2013-11-12 20:42:19 CST | Figure should be Figure 2 | 0 |
| Challenge | Anwhite3, Team WhiteShyPaulCo | 2013-10-28 18:22:35 CDT | The figure needs a caption. This could be a potential one that would work: PKC-delta is required for HIV-1 BaL replication in human macrophages. | 0 |
| Challenge | Kohli3, Team WhiteShyPaulCo | 2013-10-15 17:40:49 CDT | GO term should be 'positive regulation of retroviral genome replication' (0045870). This figure does not refer to negative regulation. It was just using protein inhibitors to demonstrate that replication would decrease in the absence of PKC-delta. Evidence should be IMP. | 0 |
| Private Assessment | Suzialeksander | 2014-01-08 20:37:41 CST | You need to be an instructor to view these notes. | Updated by Instructor ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
| Private Assessment | JimHu | 2013-11-15 14:29:09 CST | You need to be an instructor to view these notes. | Corrected Through Challenges ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
| Public Assessment | DanielRenfro | 2013-11-15 13:16:44 CST | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Private Assessment | JimHu | 2013-11-15 12:38:38 CST | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✗ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
| Public Assessment | DanielRenfro | 2013-11-14 23:43:08 CST | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Public Assessment | DanielRenfro | 2013-11-14 23:42:16 CST | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Public Assessment | DanielRenfro | 2013-11-12 20:42:19 CST | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Public Assessment | Bmcintosh | 2013-10-31 11:06:32 CDT | The minimum required for a CACAO annotation is the figure(s)/table(s). It is OPTIONAL to add additional information to explain, but not required. | Requires Changes |
| Public Assessment | DanielRenfro | 2013-10-28 18:22:35 CDT | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Public Assessment | JimHu | 2013-10-15 19:47:14 CDT | The original and challenge note do not adequately specify which panels of Figure 1 are being used for the evidence code chosen. The rest of the paper suggests that the effect on HIV replication may be too indirect to annotate; remember that we are looking for insight into the normal function of PCDdelta. However, there are other GO annotations that could be made for PKCdelta from this paper. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✔ With/From ✗ Notes ✔ Unique/Original |
| Public Assessment | DanielRenfro | 2013-10-15 17:40:49 CDT | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Private Assessment | Suzialeksander | 2013-10-14 12:52:53 CDT | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✗ Go term ✗ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
