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GO:0048525PMID:23029581IMP: Inferred from Mutant Phenotype
This annotation made on page: MOUSE:ARBK1
By: Kelsi.Carlson (group Team Shenanigans) on 2012-10-06 22:28:08 CDT.




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
ChallengeKpadda1,
Team Pterodactyl
2012-10-28 16:51:36 CDT

The GO term used is incorrect. The evidence provided in the paper indicates that GRK2 is a host factor and somehow involved in the viral reproduction of YFV-17D. When GRK2 is silenced, YFV-17D propagation significantly decreases. The results cited do not provide any evidence of the mechanism by which GRK2 is involved in viral reproduction. In this case, the more broad GO term of "viral reproduction" should be used (GO:0016032).

(Please ignore previous challenge.)

4
ChallengeKpadda1,
Team Pterodactyl
2012-10-28 16:43:08 CDT

The GO term used is incorrect. The evidence provided in the paper indicates that GRK2 is a host factor and somehow involved in the regulation of the viral reproduction of YFV-17D. When GRK2 is silenced, YFV-17D propagation significantly decreases. This evidence actually indicates that GRK2 may positively regulate the viral reproduction of YFV-17D (increase the rate/extent of the viral life cycle). However, the paper does not provide any evidence of the mechanism by which GRK2 may positively regulate viral reproduction. In this case, the more broad GO term of "regulation of viral reproduction" should be used (GO:0050792).

0
ChallengeKas2711,
Team Gene Simmons
2012-10-09 19:03:39 CDT

There is no GO term

0
Private
Assessment
Bmcintosh2012-11-15 13:24:26 CSTYou need to be an instructor to view these notes.Requires Changes
Private
Assessment
Bmcintosh2012-10-09 20:04:59 CDTYou need to be an instructor to view these notes.Requires Changes