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MOUSE:ARBK1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Adrbk1 (synonyms: Grk2) | |
| Protein Name(s) | Beta-adrenergic receptor kinase 1
Beta-ARK-1 G-protein-coupled receptor kinase 2 | |
| External Links | ||
| UniProt | Q99MK8 | |
| EMBL | AF333028 BC003196 | |
| CCDS | CCDS70915.1 | |
| RefSeq | NP_001277747.1 | |
| UniGene | Mm.254144 | |
| ProteinModelPortal | Q99MK8 | |
| SMR | Q99MK8 | |
| DIP | DIP-32413N | |
| IntAct | Q99MK8 | |
| MINT | MINT-4088166 | |
| PhosphoSite | Q99MK8 | |
| MaxQB | Q99MK8 | |
| PaxDb | Q99MK8 | |
| PRIDE | Q99MK8 | |
| Ensembl | ENSMUST00000088737 | |
| GeneID | 110355 | |
| KEGG | mmu:110355 | |
| UCSC | uc008fzu.1 | |
| CTD | 156 | |
| MGI | MGI:87940 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00770000120493 | |
| HOGENOM | HOG000006742 | |
| HOVERGEN | HBG050559 | |
| InParanoid | Q99MK8 | |
| KO | K00910 | |
| OMA | DFCLKHL | |
| PhylomeDB | Q99MK8 | |
| Reactome | REACT_207651 REACT_215587 | |
| PRO | PR:Q99MK8 | |
| Proteomes | UP000000589 | |
| Bgee | Q99MK8 | |
| CleanEx | MM_ADRBK1 | |
| ExpressionAtlas | Q99MK8 | |
| Genevestigator | Q99MK8 | |
| GO | GO:0016020 GO:0005524 GO:0047696 GO:0004703 GO:0004672 GO:0004674 GO:0002029 GO:0007186 GO:0007507 GO:0018105 GO:0018107 GO:0006468 GO:0002026 GO:0038032 | |
| Gene3D | 2.30.29.30 | |
| InterPro | IPR000961 IPR000239 IPR011009 IPR001849 IPR011993 IPR000719 IPR017441 IPR016137 IPR002290 IPR008271 | |
| Pfam | PF00169 PF00069 PF00615 | |
| PRINTS | PR00717 | |
| SMART | SM00233 SM00315 SM00133 SM00220 | |
| SUPFAM | SSF48097 SSF56112 | |
| PROSITE | PS51285 PS50003 PS00107 PS50011 PS00108 PS50132 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0022415 |
negative regulation of viral reproduction |
ECO:0000315 |
P |
Figure 3 shows that "GRK2 is required for YFV-17D propagation in mouse embryonic fibroblasts." |
complete | |||||
|
part_of |
GO:0043197 |
dendritic spine |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042699 |
follicle-stimulating hormone signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0033605 |
positive regulation of catecholamine secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0033137 |
negative regulation of peptidyl-serine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031851 |
kappa-type opioid receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031850 |
delta-type opioid receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031755 |
Edg-2 lysophosphatidic acid receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0031623 |
receptor internalization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030424 |
axon |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0019079 |
viral genome replication |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0018107 |
peptidyl-threonine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0014070 |
response to organic cyclic compound |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010801 |
negative regulation of peptidyl-threonine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010661 |
positive regulation of muscle cell apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007507 |
heart development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2180127 |
P |
results_in_development_of:(EMAPA:17339)|results_in_development_of:(EMAPA:17342)|results_in_development_of:(EMAPA:17320)|results_in_development_of:(EMAPA:17326) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0007217 |
tachykinin receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006979 |
response to oxidative stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005901 |
caveola |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004703 |
G protein-coupled receptor kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2180127 |
F |
has_direct_input:(MGI:MGI:97914) |
Seeded From UniProt |
complete | |
|
enables |
GO:0004703 |
G protein-coupled receptor kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004703 |
G protein-coupled receptor kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004703 |
G protein-coupled receptor kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0003108 |
negative regulation of the force of heart contraction by chemical signal |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0002029 |
desensitization of G protein-coupled receptor signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:87937 |
P |
occurs_in:(EMAPA:16105) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0002029 |
desensitization of G protein-coupled receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2180127 |
P |
occurs_in:(EMAPA:32688) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0002029 |
desensitization of G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0002026 |
regulation of the force of heart contraction |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:87937 |
P |
regulates_o_has_participant:(EMAPA:16105) |
Seeded From UniProt |
complete | |
|
enables |
GO:0001664 |
G protein-coupled receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000463 |
positive regulation of excitatory postsynaptic potential |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000117 |
negative regulation of cysteine-type endopeptidase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1990869 |
cellular response to chemokine |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1904707 |
positive regulation of vascular smooth muscle cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1904058 |
positive regulation of sensory perception of pain |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1900077 |
negative regulation of cellular response to insulin stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0106072 |
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0097756 |
negative regulation of blood vessel diameter |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0097110 |
scaffold protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071364 |
cellular response to epidermal growth factor stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071333 |
cellular response to glucose stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060048 |
cardiac muscle contraction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051457 |
maintenance of protein location in nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048709 |
oligodendrocyte differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048146 |
positive regulation of fibroblast proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0047696 |
beta-adrenergic receptor kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046718 |
viral entry into host cell |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046325 |
negative regulation of glucose import |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045988 |
negative regulation of striated muscle contraction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045907 |
positive regulation of vasoconstriction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045744 |
negative regulation of G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045410 |
positive regulation of interleukin-6 biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045202 |
synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043198 |
dendritic shaft |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2062 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0051457 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060048 |
cardiac muscle contraction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P25098 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P25098 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045988 |
negative regulation of striated muscle contraction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P25098 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031755 |
Edg-2 lysophosphatidic acid receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P25098 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031623 |
receptor internalization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P25098 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019079 |
viral genome replication |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P25098 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007217 |
tachykinin receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P25098 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P25098 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003108 |
negative regulation of the force of heart contraction by chemical signal |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P25098 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004703 |
G protein-coupled receptor kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000239 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000239 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047696 |
beta-adrenergic receptor kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005929 |
cilium |
Reactome:R-MMU-5632665 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Le Sommer, C et al. (2012) G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication. PLoS Negl Trop Dis 6 e1820 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Sanchez-Perez, A et al. (2007) GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2. Biochem. Biophys. Res. Commun. 359 611-5 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Wang, Q et al. (2004) Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science 304 1940-4 PubMed GONUTS page
- ↑ 4.0 4.1 Jaber, M et al. (1996) Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proc. Natl. Acad. Sci. U.S.A. 93 12974-9 PubMed GONUTS page
- ↑ 5.0 5.1 Weissman, JT et al. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. Oncogene 23 241-9 PubMed GONUTS page
- ↑ Benovic, JL et al. (1991) Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. J. Biol. Chem. 266 14939-46 PubMed GONUTS page
- ↑ 7.0 7.1 Koch, WJ et al. (1995) Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science 268 1350-3 PubMed GONUTS page
- ↑ Cho, MC et al. (1999) Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. Circulation 99 2702-7 PubMed GONUTS page
c
- GO:0060048 ! cardiac muscle contraction
- GO:0005901 ! caveola
- GO:1990869 ! cellular response to chemokine
- GO:0071364 ! cellular response to epidermal growth factor stimulus
- GO:0071333 ! cellular response to glucose stimulus
- Chordata
- GO:0005929 ! cilium
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005829 ! cytosol
d
e
g
m
n
- GO:0106072 ! negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:1900077 ! negative regulation of cellular response to insulin stimulus
- GO:2000117 ! negative regulation of cysteine-type endopeptidase activity
- GO:0003108 ! negative regulation of the force of heart contraction by chemical signal
- GO:0045988 ! negative regulation of striated muscle contraction
- GO:0010801 ! negative regulation of peptidyl-threonine phosphorylation
- GO:0033137 ! negative regulation of peptidyl-serine phosphorylation
- GO:0043066 ! negative regulation of apoptotic process
- GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway
- GO:0046325 ! negative regulation of D-glucose import
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
o
p
- GO:0018105 ! peptidyl-serine phosphorylation
- GO:0018107 ! peptidyl-threonine phosphorylation
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:0045907 ! positive regulation of vasoconstriction
- GO:0045410 ! positive regulation of interleukin-6 biosynthetic process
- GO:0033605 ! positive regulation of catecholamine secretion
- GO:0048146 ! positive regulation of fibroblast proliferation
- GO:1904058 ! positive regulation of sensory perception of pain
- GO:1904707 ! positive regulation of vascular associated smooth muscle cell proliferation
- GO:2000463 ! positive regulation of excitatory postsynaptic potential
- GO:0010661 ! positive regulation of muscle cell apoptotic process
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
r
s
