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Category:Team Gene Simmons

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
requireschangesMOUSE:RPTORSamtaylor, Team Gene Simmons2012-11-18 17:40:31 CSTGO:0004674 protein serine/threonine kinase activity (F)PMID:23092880ECO:0000314 direct assay evidence used in manual assertion

Fig 3 shows the effect of mutations of the akt activity

challenge
requireschangesMOUSE:RICTRSamtaylor, Team Gene Simmons2012-11-18 17:40:01 CSTGO:0004674 protein serine/threonine kinase activity (F)PMID:23092880ECO:0000314 direct assay evidence used in manual assertion

figure 3 shows the effect of mutations of the akt activity

challenge
acceptableDANRE:B3DHL9Samtaylor, Team Gene Simmons2012-11-18 17:35:39 CSTGO:0007498 mesoderm development (P)PMID:22927438ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 6A shows reduced mesoderm in mutants

challenge
unacceptableMOUSE:HEPCSamtaylor, Team Gene Simmons2012-11-18 17:34:55 CSTGO:0033619 membrane protein proteolysis (P)PMID:15514116ECO:0000314 direct assay evidence used in manual assertion

Figure 3 shows induction of ferroportin degradation.

challenge
unacceptableXENLA:Q8AWZ9Samtaylor, Team Gene Simmons2012-11-18 17:03:25 CSTGO:2001259 positive regulation of cation channel activity (P)PMID:21576493ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 2. shows the presence of KCNE1 bound to KCNQ1 increases channel sensitivity of PiP2 and alters the IKs.

challenge
acceptableHUMAN:DACH1Samtaylor, Team Gene Simmons2012-11-18 16:18:15 CSTGO:2000279 negative regulation of DNA biosynthetic process (P)PMID:16980615ECO:0000314 direct assay evidence used in manual assertion

figure 2 shows dna synthesis inhibition through the DS domain of DACH1

challenge
unacceptableHUMAN:DACH1Samtaylor, Team Gene Simmons2012-11-18 16:13:39 CSTGO:0048147 negative regulation of fibroblast proliferation (P)PMID:16980615ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1 shows induction of DACH1 represses colony formation and tumor growth.

challenge
updatedbyinstructorMOUSE:RICTRSamtaylor, Team Gene Simmons2012-11-18 15:06:05 CSTGO:0001932 regulation of protein phosphorylation (P)PMID:23092880ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3A shows regulation of akt phosphorylation.

challenge
updatedbyinstructorMOUSE:RPTORSamtaylor, Team Gene Simmons2012-11-18 14:40:19 CSTGO:0001932 regulation of protein phosphorylation (P)PMID:23092880ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3 shows regulation of akt phosphorylation

challenge
acceptableHUMAN:KPYMSamtaylor, Team Gene Simmons2012-11-18 14:22:04 CSTGO:0004743 pyruvate kinase activity (F)PMID:20005212ECO:0000314 direct assay evidence used in manual assertion

Figure 2 kinetic characterization of enzyme activity

challenge
acceptableMOUSE:NEK1Samtaylor, Team Gene Simmons2012-11-18 13:40:06 CSTGO:2000001 regulation of DNA damage checkpoint (P)PMID:18843199ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2a shows specific Nek1 expression in Nek1−/− mutants restores ability to arrest cell cell development when dna damage is present.

challenge
unacceptableHUMAN:CAH1Sarahtheriault, Team Gene Simmons2012-11-18 13:27:29 CSTGO:0004064 arylesterase activity (F)PMID:7758465ECO:0000315 mutant phenotype evidence used in manual assertion

Table 4

challenge
acceptableDROME:FRUSarahtheriault, Team Gene Simmons2012-11-18 13:08:25 CSTGO:0021954 central nervous system neuron development (P)PMID:16281036ECO:0000314 direct assay evidence used in manual assertion

Figure 3

challenge
requireschangesDANRE:B3DHL9Samtaylor, Team Gene Simmons2012-11-17 20:30:58 CSTGO:0010467 gene expression (P)PMID:22927438ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 6b shows alterations in the levels of gene expression.

challenge
acceptableBPPRD:VLYSSarahtheriault, Team Gene Simmons2012-11-17 19:19:14 CSTGO:0051672 catabolism by organism of cell wall peptidoglycan in other organism (P)PMID:10931330ECO:0000314 direct assay evidence used in manual assertion

Figure 4

challenge
updatedbyinstructorMOUSE:RHEBSamtaylor, Team Gene Simmons2012-11-16 11:52:39 CSTGO:0032006 regulation of TOR signaling cascade (P)PMID:19258434ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 1 & Fig 5C show rapamycin suppresses the activity of mTORC1

challenge
acceptableMOUSE:PTENSamtaylor, Team Gene Simmons2012-11-15 23:21:47 CSTGO:0060341 regulation of cellular localization (P)PMID:21266327ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 4C shows a shift in FoxO1 localization from the nucleus to the cytoplasm in Pten knockout mutants.

challenge
acceptableHUMAN:RHEBSamtaylor, Team Gene Simmons2012-11-15 22:27:29 CSTGO:2000074 regulation of type B pancreatic cell development (P)PMID:19258434ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3 shows increased beta cell mass in transgenic mice.

challenge
acceptableARATH:NRT24Sarahtheriault, Team Gene Simmons2012-11-13 20:53:10 CSTGO:0015706 nitrate transport (P)PMID:22227893ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 5

challenge
updatedbyinstructorHUMAN:CATSSarahtheriault, Team Gene Simmons2012-11-13 20:11:33 CSTGO:0016485 protein processing (P)PMID:22864553ECO:0000314 direct assay evidence used in manual assertion

Figure 6

challenge
acceptableECOLI:GAL7Sarahtheriault, Team Gene Simmons2012-11-13 19:59:45 CSTGO:0004335 galactokinase activity (F)PMID:18263746ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2

challenge
updatedbyinstructorYERPE:Q7CFY4Sarahtheriault, Team Gene Simmons2012-11-13 19:48:23 CSTGO:0030260 entry into host cell (P)PMID:22851752ECO:0000314 direct assay evidence used in manual assertion

Figure 4

challenge
acceptableBPPRD:VLYSSarahtheriault, Team Gene Simmons2012-11-13 19:42:09 CSTGO:0003796 lysozyme activity (F)PMID:10931330ECO:0000314 direct assay evidence used in manual assertion

Figure 4

challenge
updatedbyinstructorBPPRD:EXLYSSarahtheriault, Team Gene Simmons2012-11-13 19:34:53 CSTGO:0051672 catabolism by organism of cell wall peptidoglycan in other organism (P)PMID:10931330ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4

challenge
updatedbyinstructorBPPRD:VLYSSarahtheriault, Team Gene Simmons2012-11-13 19:21:14 CSTGO:0044277 cell wall disassembly (P)PMID:7925454ECO:0000314 direct assay evidence used in manual assertion

Figure 3

challenge
requireschangesBPPRD:VLYSSarahtheriault, Team Gene Simmons2012-11-13 19:18:42 CSTGO:0009408 response to heat (P)PMID:7925454ECO:0000314 direct assay evidence used in manual assertion

Figure 2

challenge
requireschangesBPPRD:VLYSSarahtheriault, Team Gene Simmons2012-11-13 19:16:40 CSTGO:0009268 response to pH (P)PMID:7925454ECO:0000314 direct assay evidence used in manual assertion

Figure 2

challenge
acceptableBPPRD:VLYSSarahtheriault, Team Gene Simmons2012-11-13 19:14:26 CSTGO:0003796 lysozyme activity (F)PMID:7925454ECO:0000314 direct assay evidence used in manual assertion

Figure 2

challenge
acceptableECOLI:MQSRSarahtheriault, Team Gene Simmons2012-11-12 18:27:40 CSTGO:0045892 negative regulation of transcription, DNA-dependent (P)PMID:16352847ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 5

challenge
acceptableRAT:HXK1Sarahtheriault, Team Gene Simmons2012-11-12 18:04:52 CSTGO:0004396 hexokinase activity (F)PMID:2457393ECO:0000314 direct assay evidence used in manual assertion

Figure 1

challenge
unacceptableBPPRD:VP11Sarahtheriault, Team Gene Simmons2012-11-11 18:30:52 CSTGO:0008933 lytic transglycosylase activity (F)PMID:11741849ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3

challenge
requireschangesMAIZE:Q9AXG8Sarahtheriault, Team Gene Simmons2012-11-11 18:16:43 CSTGO:1900179 positive regulation of aflatoxin biosynthetic process (P)PMID:19132874ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2

challenge
acceptableDANRE:B3DHL9Samtaylor, Team Gene Simmons2012-11-04 17:50:28 CSTGO:0006355 regulation of transcription, DNA-dependent (P)PMID:22927438ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 6B shows early gene expression is modulated by kcnh1 following transcription.

challenge
updatedbyinstructorMOUSE:SYT1Samtaylor, Team Gene Simmons2012-11-03 21:16:35 CDTGO:0017158 regulation of calcium ion-dependent exocytosis (P)PMID:11562488ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 2 & Fig 4. Figure 2D. shows a decrease in the exocytotic burst amplitude of SYT1 mutants.

challenge
updatedbyinstructorMOUSE:OTOFSamtaylor, Team Gene Simmons2012-11-03 18:30:29 CDTGO:0016082 synaptic vesicle priming (P)PMID:20562868ECO:0000315 mutant phenotype evidence used in manual assertion

Figs 4&5.

challenge
updatedbyinstructorMOUSE:RPTORSamtaylor, Team Gene Simmons2012-11-02 20:47:56 CDTGO:0046676 negative regulation of insulin secretion (P)PMID:23092880ECO:0000315 mutant phenotype evidence used in manual assertion

Fig.1D, insulinn secretion at 20mmol/l glucose was increased in the Raptor treated cells.

challenge
unacceptableSTRMG:Q8VUG9Sarahtheriault, Team Gene Simmons2012-10-30 20:39:57 CDTGO:0046677 response to antibiotic (P)PMID:12435673ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1

challenge
acceptableHUMAN:IL21Sarahtheriault, Team Gene Simmons2012-10-30 20:33:12 CDTGO:0001819 positive regulation of cytokine production (P)PMID:19322899ECO:0000314 direct assay evidence used in manual assertion

Figure 3

challenge
acceptableSTRA1:PURASarahtheriault, Team Gene Simmons2012-10-30 20:13:24 CDTGO:0004019 adenylosuccinate synthase activity (F)PMID:15882424ECO:0000314 direct assay evidence used in manual assertion

Table 5

challenge
acceptableMEDTR:D2IU94Sarahtheriault, Team Gene Simmons2012-10-30 19:43:31 CDTGO:0010015 root morphogenesis (P)PMID:22858636ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 6

challenge
acceptableMEDTR:D2IU94Sarahtheriault, Team Gene Simmons2012-10-30 19:42:20 CDTGO:0042128 nitrate assimilation (P)PMID:22858636ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1

challenge
updatedbyinstructorHUMAN:CATSSarahtheriault, Team Gene Simmons2012-10-30 19:39:13 CDTGO:0006508 proteolysis (P)PMID:22864553ECO:0000314 direct assay evidence used in manual assertion

Figure 7

challenge
updatedbyinstructorSTRAG:Q8VQA0Sarahtheriault, Team Gene Simmons2012-10-30 19:31:25 CDTGO:0004721 phosphoprotein phosphatase activity (F)PMID:15882424ECO:0000314 direct assay evidence used in manual assertion

Figure 6

challenge
updatedbyinstructorSTRAG:Q8VQA0Sarahtheriault, Team Gene Simmons2012-10-30 19:30:39 CDTGO:0006470 protein dephosphorylation (P)PMID:15882424ECO:0000314 direct assay evidence used in manual assertion

Figure 6, Lane 1

challenge
unacceptable?Sarahtheriault, Team Gene Simmons2012-10-30 19:28:44 CDTGO:0006164 purine nucleotide biosynthetic process (Figure 2)PMID:15882424IMP: Inferred from Mutant Phenotype
challenge
updatedbyinstructorSTRAG:Q8VQA0Sarahtheriault, Team Gene Simmons2012-10-30 19:23:03 CDTGO:0006468 protein phosphorylation (P)PMID:15882424ECO:0000314 direct assay evidence used in manual assertion

Figure 6

challenge
unacceptableMAIZE:B4FRJ1Sarahtheriault, Team Gene Simmons2012-10-30 19:19:52 CDTGO:0009505 plant-type cell wall (C)PMID:21889053ECO:0000314 direct assay evidence used in manual assertion

Figure 3: The authors show the MDH protein is associated with the cell wall of the plant cells.

challenge
unacceptableMAIZE:B4FRJ1Sarahtheriault, Team Gene Simmons2012-10-30 19:16:23 CDTGO:0016615 malate dehydrogenase activity (F)PMID:21889053ECO:0000314 direct assay evidence used in manual assertion

Figure 1

challenge
updatedbyinstructorHHV1K:DNBIHannah smalley, Team Gene Simmons2012-10-20 21:36:38 CDTGO:0010792 DNA double-strand break processing involved in repair via single-strand annealing (P)PMID:22912580ECO:0000315 mutant phenotype evidence used in manual assertion

Refer to Fig. 6

challenge
acceptableHHV1:Q68978Hannah smalley, Team Gene Simmons2012-10-20 21:31:58 CDTGO:0010792 DNA double-strand break processing involved in repair via single-strand annealing (P)PMID:22912580ECO:0000314 direct assay evidence used in manual assertion

Refer to Fig. 5

challenge
updatedbyinstructorMOUSE:RAD52Hannah smalley, Team Gene Simmons2012-10-20 21:15:17 CDTGO:0010792 DNA double-strand break processing involved in repair via single-strand annealing (P)PMID:22912580ECO:0000315 mutant phenotype evidence used in manual assertion

Refer to Fig. 6

challenge
acceptableMOUSE:PO3F2Samtaylor, Team Gene Simmons2012-10-17 23:13:18 CDTGO:0010629 negative regulation of gene expression (P)PMID:23069940ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2c shows loss of T-cadherin expression accompanied with the overexpression of BRN2

challenge
requireschangesEBOZM:VP35Sarahtheriault, Team Gene Simmons2012-10-17 21:48:22 CDTGO:0046983 protein dimerization activity (F)PMID:12829834ECO:0000314 direct assay evidence used in manual assertion

Figure 4: VP35 blocks dimerization

challenge
acceptableEBOZM:VP35Sarahtheriault, Team Gene Simmons2012-10-17 21:44:14 CDTGO:0010629 negative regulation of gene expression (P)PMID:12829834ECO:0000314 direct assay evidence used in manual assertion

Figure 2:The Ebola virus VP35 protein can block virus-induced, IRF-3-dependent gene expression.

challenge
requireschangesHUMAN:HMDHSarahtheriault, Team Gene Simmons2012-10-17 21:28:59 CDTGO:0045541 negative regulation of cholesterol biosynthetic process (P)PMID:23063590ECO:0000314 direct assay evidence used in manual assertion

Figure 3: Artemisinic acid inhibits cholesterol synthesis by downregulating the hydroxymethylglutaryl CoA (HMG CoA) reductase gene.

challenge
acceptableHUMAN:DACH1Samtaylor, Team Gene Simmons2012-10-17 20:54:15 CDTGO:0045892 negative regulation of transcription, DNA-dependent (P)PMID:21750150ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4. shows Ectopic DACH1 expression decreases FGF2 expression, spheroid formation, and tumor growth.

challenge
updatedbyinstructorHUMAN:BRAFSarahtheriault, Team Gene Simmons2012-10-16 20:46:36 CDTGO:0090150 establishment of protein localization to membrane (P)PMID:23010278ECO:0000314 direct assay evidence used in manual assertion

Figure 3: Coexpression of B-RAF enhanced SGLT1 protein abundance at the cell surface.

challenge
acceptableHUMAN:HEPCSamtaylor, Team Gene Simmons2012-10-16 20:31:25 CDTGO:0006879 cellular iron ion homeostasis (P)PMID:15514116ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows hepcidin specifically induces the internalization of Fnp-GFP.

challenge
acceptableHUMAN:PP1ASarahtheriault, Team Gene Simmons2012-10-16 20:21:02 CDTGO:0006470 protein dephosphorylation (P)PMID:22311981ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 5: Knockdown of PP1 and PP2A isoforms in ERM dephosphorylation.

challenge
unacceptableMEDSV:PP1Sarahtheriault, Team Gene Simmons2012-10-16 19:17:48 CDTGO:0010447 response to acidity (P)PMID:22882676ECO:0000314 direct assay evidence used in manual assertion

Figure 4: Zoledronic acid (ZA) caused inhibition of phosphatase 1 (PP1) and PP2A phosphatase activity in PC3 and DU145 cells.

challenge
unacceptableMEDSV:PP1Sarahtheriault, Team Gene Simmons2012-10-16 19:09:11 CDTGO:0019212 phosphatase inhibitor activity (F)PMID:22882676ECO:0000314 direct assay evidence used in manual assertion

Figure 4: Zoledronic acid (ZA) caused inhibition of phosphatase 1 (PP1) and PP2A phosphatase activity in PC3 and DU145 cells.

challenge
acceptableHUMAN:CATSSarahtheriault, Team Gene Simmons2012-10-02 20:42:10 CDTGO:0010447 response to acidity (P)PMID:22864553ECO:0000314 direct assay evidence used in manual assertion

Figure 5: Cathepsin-S can activate ENaC in an acidic environment.

challenge
unacceptableHUMAN:CATSSarahtheriault, Team Gene Simmons2012-10-02 20:12:11 CDTGO:0097179 protease inhibitor complex (C)PMID:22864553ECO:0000314 direct assay evidence used in manual assertion

Figure 3: Cysteine protease Cathepsin-S covalently binds to the vinylsulfone residue and inhibits ENaC (cation channel) activation.

challenge
unacceptableHUMAN:CATSSarahtheriault, Team Gene Simmons2012-10-02 19:57:54 CDTGO:0008234 cysteine-type peptidase activity (F)PMID:22864553ECO:0000314 direct assay evidence used in manual assertion

Figure 2: Cysteine protease cathepsin-S activates ENaC (cation channel).

challenge
acceptableMOUSE:CATSSarahtheriault, Team Gene Simmons2012-10-02 19:50:39 CDTGO:2001259 positive regulation of cation channel activity (P)PMID:22864553ECO:0000314 direct assay evidence used in manual assertion

Figure 9: Activation of ENaC (cation channel) by cathepsin-S.

challenge
unacceptableHUMAN:CATSSarahtheriault, Team Gene Simmons2012-10-02 19:45:58 CDTGO:2001258 negative regulation of cation channel activity (P)PMID:22864553ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 8: Mutating two putative neutrophil elastase cleavage sites prevents proteolytic activation of ENaC by cathepsin-S.

challenge
unacceptableHUMAN:P53Kas2711, Team Gene Simmons2012-10-02 19:44:06 CDTGO:0000988 protein binding transcription factor activity (F)PMID:16131611ECO:0000314 direct assay evidence used in manual assertion

Figure 9-C

challenge
unacceptableHUMAN:CATSSarahtheriault, Team Gene Simmons2012-10-02 19:31:02 CDTGO:2001258 negative regulation of cation channel activity (P)PMID:22864553ECO:0000314 direct assay evidence used in manual assertion

Figure 3: ENaC (cation channel) inhibition by cathepsin-S inhibitor LHVS

challenge
acceptableHUMAN:CATSSarahtheriault, Team Gene Simmons2012-10-02 19:22:19 CDTGO:2001259 positive regulation of cation channel activity (P)PMID:22864553ECO:0000314 direct assay evidence used in manual assertion

Figure 2: ENaC (cation channel) activation by Cathepsin S

challenge
unacceptableMOUSE:TDRD1Sarahtheriault, Team Gene Simmons2012-09-23 17:48:54 CDTGO:0005515 protein binding (F)PMID:22996915ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1B

challenge
unacceptableMOUSE:CXA1Sarahtheriault, Team Gene Simmons2012-09-23 17:26:32 CDTGO:0005243 gap junction channel activity (F)PMID:22197781ECO:0000314 direct assay evidence used in manual assertion

Table 1: Interactions between gap junction proteins

challenge
unacceptableYEAST:MRE11Hannah smalley, Team Gene Simmons2012-09-23 16:22:10 CDTGO:0010780 meiotic DNA double-strand break formation involved in reciprocal meiotic recombination (P)PMID:7625279ECO:0000315 mutant phenotype evidence used in manual assertion

Table 1

challenge

CACAO assessment

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Pages in category "Team Gene Simmons"

The following 4 pages are in this category, out of 4 total.


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