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Cacao

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GO:1903301positive regulation of hexokinase activityPMID:24390321IDA: Inferred from Direct Assay P
This annotation made on page: HCVH:POLG
By: MayurSST (group Team Donuts) on 2018-10-02 14:12:30 CDT.



TeamPoints
Team Donuts5




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
ChallengeMayurSST,
Team Donuts
2018-10-23 13:03:42 CDT

Also needs to have Hexokinase II.

None, yet.
ChallengeMayurSST,
Team Donuts
2018-10-23 13:02:35 CDT

The Uniprot ID should be P27958.

5
ChallengeMckaelaAutumn19,
Team BICH
2018-10-09 13:54:16 CDT

The protein is correct. The protein should be HCVCO:POLG because in the methods section, lines 25 and 26 under PCA identify that the plasmids used are coding for Con1 NS5A protein (pGluc1-NS5A).

The original notes are "Figure 7 shows statistically significant increases in hexokinase activity due to NS5A. Hepatitis C NS5A was used on Human Hexokinase.". It should be "Figure 7 shows statistically significant increases in hexokinase activity due to NS5A/NS5A protein/Con1 NS5A protein/pGluc1-NS5A/Hepatitis C Virus NS5A protein/genome polyprotein. Hepatitis C NS5A was used on Human Hexokinase."This includes the correct protein names included in the paper and the protein name included in UniProt.

None, yet.
ChallengeVanessaDoan,
Team Mighty Chondria
2018-10-09 13:26:49 CDT

The correct uniprot ID is E7ELX7 the name is Genome polyprotein. The paper says they use Huh7.5 cells, and when you go to reference 15 it says that it uses the strain "HCV genome J6/JFH-1" which matches with the organism on uniprot "Recombinant Hepatitis C virus J6/JFH1(HCV1-NS5A)". On viral zone it proves that it is on polyprotein.

None, yet.
Private
Assessment
Sandyl 272019-04-17 15:22:21 CDTYou need to be an instructor to view these notes.Updated by Instructor
Private
Assessment
Sandyl 272018-10-23 13:32:27 CDTYou need to be an instructor to view these notes.Corrected Through Challenges
Protein
Publication
Qualifier
Go term
Evidence
With/From
Notes
Unique/Original
Public
Assessment
DanielRenfro2018-10-23 13:03:42 CDT

This annotation has been flagged because it has been challenged since last assessment

Flagged
Public
Assessment
DanielRenfro2018-10-23 13:02:35 CDT

This annotation has been flagged because it has been challenged since last assessment

Flagged
Private
Assessment
Jrr2018-10-16 14:52:14 CDTYou need to be an instructor to view these notes.Requires Changes
Protein
Private
Assessment
Jrr2018-10-10 10:13:48 CDTYou need to be an instructor to view these notes.Flagged
Public
Assessment
DanielRenfro2018-10-09 13:54:16 CDT

This annotation has been flagged because it has been challenged since last assessment

Flagged
Public
Assessment
DanielRenfro2018-10-09 13:26:49 CDT

This annotation has been flagged because it has been challenged since last assessment

Flagged
Private
Assessment
CRoss20082018-10-02 15:22:38 CDTYou need to be an instructor to view these notes.Requires Changes
Protein
Publication
Qualifier
Go term
Evidence
With/From
Notes
Unique/Original