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Cacao

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GO:0006260DNA replicationPMID:10559179IGI: Inferred from Genetic Interaction P
This annotation made on page: BPT4:REPEA
By: SSingh (group Team Purple B 2018) on 2018-03-04 19:10:41 CST.




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
Public
Assessment		Ivanerill2018-04-15 13:43:02 CDT

You annotate BPT4:REPEA. Note that there is a free annotation in the same figure.

Acceptable
✔ Protein
✔ Publication
✔ Qualifier
✔ Go term
✔ Evidence
✔ With/From
✔ Notes
✔ Unique/Original
Public
Assessment		DanielRenfro2018-03-11 22:31:19 CDT

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0090592 DNA synthesis involved in DNA replication PMID:10559179 IMP: Inferred from Mutant Phenotype P repEA is an important gene in DNA synthesis and phage growth of phage T4. However, due to the amalgamation of several initiation sites in the T4 genome, mutations in repEA are not lethal. Nonsense mutations of repEA in conjunction with mot4 (to reduce initiation from different sources) mutations in phages showed smaller plaques compared to phages without both of these mutations (data not shown - from "Nonsense mutations in the repEA and repEB genes in combination with a motA mutation affect phage growth.")

The same repEA and mot4 mutation was shown to synthesize much less DNA compared to that of the phage with just the mot4 mutation (Figure 6), which was indicative of the importance of repEA versus other initiator proteins in DNA synthesis.||complete
CACAO 13097

on BPT4:REPEA
Flagged
Public
Assessment		Ivanerill2018-03-08 15:46:50 CST

Figure 6 refers to DNA synthesis, not replication (which, anyhow, would be viral). Check also whether IGI is the better evidence code to apply here. The nice introduction in the notes is nice, but what really needs explaining is the annotation itself.

Requires Changes
✗ Go term
✗ Evidence
✗ Notes


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