BPT4:REPEA

Species (Taxon ID)	Enterobacteria phage T4 (Bacteriophage T4). (10665)
Gene Name(s)	repEA (synonyms: dbpB)
Protein Name(s)	DNA replication protein repEA DNA-binding protein dbpB
External Links
UniProt	P32284
EMBL	X15728 AF158101
RefSeq	NP_049759.1
PRIDE	P32284
GeneID	1258819
KEGG	vg:1258819
Proteomes	UP000009087
GO	GO:0003677 GO:0006260

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0090592	DNA synthesis involved in DNA replication	PMID:10559179	ECO:0000315			P		repEA is an important gene in DNA synthesis and phage growth of phage T4. However, due to the amalgamation of several initiation sites in the T4 genome, mutations in repEA are not lethal. Nonsense mutations of repEA in conjunction with mot4 (to reduce initiation from different sources) mutations in phages showed smaller plaques compared to phages without both of these mutations (data not shown - from "Nonsense mutations in the repEA and repEB genes in combination with a motA mutation affect phage growth.") The same repEA and mot4 mutation was shown to synthesize much less DNA compared to that of the phage with just the mot4 mutation (Figure 6), which was indicative of the importance of repEA versus other initiator proteins in DNA synthesis.	complete CACAO 13097
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
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