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STRPY:HASA
Contents
| Species (Taxon ID) | Streptococcus pyogenes. (1314) | |
| Gene Name(s) | hasA | |
| Protein Name(s) | Hyaluronan synthase
Hyaluronate synthase Hyaluronic acid synthase HA synthase | |
| External Links | ||
| UniProt | P0C0H0 | |
| EMBL | L21187 | |
| ProteinModelPortal | P0C0H0 | |
| CAZy | GT2 | |
| TCDB | 4.D.1.1.4 | |
| eggNOG | COG1215 | |
| SABIO-RK | P0C0H0 | |
| UniPathway | UPA00341 | |
| GO | GO:0016021 GO:0005886 GO:0050501 GO:0042710 GO:0030213 GO:0009405 | |
| Gene3D | 3.90.550.10 | |
| InterPro | IPR001173 IPR026107 IPR029044 | |
| PANTHER | PTHR22913 | |
| Pfam | PF00535 | |
| SUPFAM | SSF53448 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0050501 |
hyaluronan synthase activity |
ECO:0000315 |
F |
Based on fig. 1, hyaluronan(HA) synthase gene was identified based on the fact that Tn insertional mutagenesis caused the band on the gel. Fig. 4 shows the presence of HasA in E. coli with pPD41-delta5 (lane C) and pPD41-deltaPstI(lane D) while table 1 shows positive HA production for strains that contain the plasmid. Strains with pPD41-deltaPstI show little activity for HA synthesis because no HasB present which is required for the reaction. |
complete | |||||
| GO:0090609 |
single-species submerged biofilm formation |
ECO:0000315 |
P |
Figure 5. shows that HasA mutants were unable to form biofilm. |
complete | |||||
|
Contributes to |
GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
Table 2. HasA is involved in the production of the hyaluronic acid capsule. Hyaluronic acid mimics host connective tissue. |
complete | ||||
|
Contributes to |
GO:0009405 |
pathogenesis |
ECO:0000314 |
P |
Figure 2 Strep A species lack hasABC genes needed for hyaluronic acid capsule formation, which contributes to Strep species pathogenesis. |
complete | ||||
|
involved_in |
GO:0090609 |
single-species submerged biofilm formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050501 |
hyaluronan synthase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016757 |
transferase activity, transferring glycosyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030213 |
hyaluronan biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00341 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ DeAngelis, PL et al. (1993) Molecular cloning, identification, and sequence of the hyaluronan synthase gene from group A Streptococcus pyogenes. J. Biol. Chem. 268 19181-4 PubMed GONUTS page
- ↑ 2.0 2.1 Cho, KH & Caparon, MG (2005) Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes. Mol. Microbiol. 57 1545-56 PubMed GONUTS page
- ↑ Cole, JN et al. (2011) Molecular insight into invasive group A streptococcal disease. Nat. Rev. Microbiol. 9 724-36 PubMed GONUTS page
- ↑ Flores, AR et al. (2012) Human disease isolates of serotype m4 and m22 group a streptococcus lack genes required for hyaluronic acid capsule biosynthesis. MBio 3 e00413-12 PubMed GONUTS page
