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STRPY:HASA

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Species (Taxon ID) Streptococcus pyogenes. (1314)
Gene Name(s) hasA
Protein Name(s) Hyaluronan synthase

Hyaluronate synthase Hyaluronic acid synthase HA synthase

External Links
UniProt P0C0H0
EMBL L21187
ProteinModelPortal P0C0H0
CAZy GT2
TCDB 4.D.1.1.4
eggNOG COG1215
SABIO-RK P0C0H0
UniPathway UPA00341
GO GO:0016021
GO:0005886
GO:0050501
GO:0042710
GO:0030213
GO:0009405
Gene3D 3.90.550.10
InterPro IPR001173
IPR026107
IPR029044
PANTHER PTHR22913
Pfam PF00535
SUPFAM SSF53448

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0050501

hyaluronan synthase activity

PMID:8366070[1]

ECO:0000315

F

Based on fig. 1, hyaluronan(HA) synthase gene was identified based on the fact that Tn insertional mutagenesis caused the band on the gel.

Fig. 4 shows the presence of HasA in E. coli with pPD41-delta5 (lane C) and pPD41-deltaPstI(lane D) while table 1 shows positive HA production for strains that contain the plasmid. Strains with pPD41-deltaPstI show little activity for HA synthesis because no HasB present which is required for the reaction.

complete
CACAO 4493

GO:0090609

single-species submerged biofilm formation

PMID:16135223[2]

ECO:0000315

P

Figure 5. shows that HasA mutants were unable to form biofilm.

complete
CACAO 5246

Contributes to

GO:0009405

pathogenesis

PMID:21921933[3]

ECO:0000315

P

Table 2.

HasA is involved in the production of the hyaluronic acid capsule. Hyaluronic acid mimics host connective tissue.

complete
CACAO 11270

Contributes to

GO:0009405

pathogenesis

PMID:23131832[4]

ECO:0000314

P

Figure 2 Strep A species lack hasABC genes needed for hyaluronic acid capsule formation, which contributes to Strep species pathogenesis.

complete
CACAO 11275

involved_in

GO:0090609

single-species submerged biofilm formation

PMID:16135223[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050501

hyaluronan synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.1.212

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0843

P

Seeded From UniProt

complete

involved_in

GO:0030213

hyaluronan biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00341

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. DeAngelis, PL et al. (1993) Molecular cloning, identification, and sequence of the hyaluronan synthase gene from group A Streptococcus pyogenes. J. Biol. Chem. 268 19181-4 PubMed GONUTS page
  2. 2.0 2.1 Cho, KH & Caparon, MG (2005) Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes. Mol. Microbiol. 57 1545-56 PubMed GONUTS page
  3. Cole, JN et al. (2011) Molecular insight into invasive group A streptococcal disease. Nat. Rev. Microbiol. 9 724-36 PubMed GONUTS page
  4. Flores, AR et al. (2012) Human disease isolates of serotype m4 and m22 group a streptococcus lack genes required for hyaluronic acid capsule biosynthesis. MBio 3 e00413-12 PubMed GONUTS page