GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:21921933
| Citation |
Cole, JN, Barnett, TC, Nizet, V and Walker, MJ (2011) Molecular insight into invasive group A streptococcal disease. Nat. Rev. Microbiol. 9:724-36 |
|---|---|
| Abstract |
Streptococcus pyogenes is also known as group A Streptococcus (GAS) and is an important human pathogen that causes considerable morbidity and mortality worldwide. The GAS serotype M1T1 clone is the most frequently isolated serotype from life-threatening invasive (at a sterile site) infections, such as streptococcal toxic shock-like syndrome and necrotizing fasciitis. Here, we describe the virulence factors and newly discovered molecular events that mediate the in vivo changes from non-invasive GAS serotype M1T1 to the invasive phenotype, and review the invasive-disease trigger for non-M1 GAS. Understanding the molecular basis and mechanism of initiation for streptococcal invasive disease may expedite the discovery of novel therapeutic targets for the treatment and control of severe invasive GAS diseases. |
| Links |
PubMed Online version:10.1038/nrmicro2648 |
| Keywords |
Animals; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Humans; Serotyping; Streptococcal Infections/epidemiology; Streptococcal Infections/microbiology; Streptococcal Infections/pathology; Streptococcus pyogenes/genetics; Streptococcus pyogenes/immunology; Streptococcus pyogenes/pathogenicity; Virulence Factors/genetics; Virulence Factors/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
Contributes to |
GO:0009405: pathogenesis |
ECO:0000315: |
P |
Table 2. UDG aids in the production of the hyaluronic acid capsule which mimics hair connective tissue. |
complete | |||
|
Contributes to |
GO:0009405: pathogenesis |
ECO:0000315: |
P |
Table 2. HasA is involved in the production of the hyaluronic acid capsule. Hyaluronic acid mimics host connective tissue. |
complete | |||
|
Contributes to |
GO:0009405: pathogenesis |
ECO:0000315: |
P |
Table 2. HasC1 aids in the production of a hyaluronic acid capsule. The capsule helps to evade phagocytosis. |
complete | |||
|
Contributes to |
GO:0009405: pathogenesis |
ECO:0000315: |
P |
Table 2. HasC2 aids in the production of a hyaluronic acid capsule. The capsule helps to evade phagocytosis. |
complete | |||
Notes
See also
References
See Help:References for how to manage references in GONUTS.
