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STRPY:UDG

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Species (Taxon ID) Streptococcus pyogenes. (1314)
Gene Name(s) hasB
Protein Name(s) UDP-glucose 6-dehydrogenase

UDP-Glc dehydrogenase UDP-GlcDH UDPGDH

External Links
UniProt P0C0F4
EMBL L08444
RefSeq WP_011018341.1
PDB 1DLI
1DLJ
1LTY
PDBsum 1DLI
1DLJ
1LTY
ProteinModelPortal P0C0F4
SMR P0C0F4
eggNOG COG1004
SABIO-RK P0C0F4
UniPathway UPA00038
EvolutionaryTrace P0C0F4
GO GO:0051287
GO:0003979
GO:0000271
GO:0006065
Gene3D 1.10.1040.10
3.40.50.720
InterPro IPR008927
IPR013328
IPR016040
IPR017476
IPR014027
IPR014026
IPR001732
IPR028357
PANTHER PTHR11374
Pfam PF00984
PF03720
PF03721
PIRSF PIRSF500134
PIRSF000124
SMART SM00984
SUPFAM SSF48179
SSF52413
TIGRFAMs TIGR03026

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

Contributes to

GO:0009405

pathogenesis

PMID:21921933[1]

ECO:0000315

P

Table 2.

UDG aids in the production of the hyaluronic acid capsule which mimics hair connective tissue.

complete
CACAO 11272

GO:0003979

UDP-glucose 6-dehydrogenase activity

PMID:8463246[2]

ECO:0000314

F

table 1 shows UDP-glucose dehydrogenase activity of Streptococcus pyogenes and E. coli with hasB-containing pGAC147 plasmid

complete
CACAO 4489

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

PMID:8463246[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000271

polysaccharide biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028357

P

Seeded From UniProt

complete

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028357

F

Seeded From UniProt

complete

enables

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001732
InterPro:IPR014026
InterPro:IPR014027
InterPro:IPR017476

F

Seeded From UniProt

complete

enables

GO:0051287

NAD binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001732
InterPro:IPR014026
InterPro:IPR014027

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001732
InterPro:IPR008927
InterPro:IPR014026
InterPro:IPR014027
InterPro:IPR017476

P

Seeded From UniProt

complete

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.22

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0006065

UDP-glucuronate biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00038

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Cole, JN et al. (2011) Molecular insight into invasive group A streptococcal disease. Nat. Rev. Microbiol. 9 724-36 PubMed GONUTS page
  2. 2.0 2.1 Dougherty, BA & van de Rijn, I (1993) Molecular characterization of hasB from an operon required for hyaluronic acid synthesis in group A streptococci. Demonstration of UDP-glucose dehydrogenase activity. J. Biol. Chem. 268 7118-24 PubMed GONUTS page