It is now the 5th OPEN Period for CACAO Fall 2017! It will end on Tuesday November 21, 2017 at 11:59 pm CST
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at


Jump to: navigation, search
Saccharomyces cerevisiae (baker's yeast)

CDC54:Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication
Synonyms:YPR019W, HCD21, MCM4
CDC54 on SGD

GO terms

GO:0003682_!_chromatin_binding (F) TAS [1]
GO:0004003_!_ATP-dependent_DNA_helicase_activity (F) TAS [2]
GO:0005634_!_nucleus (C) IDA [3]
GO:0005656_!_pre-replicative_complex (C) IDA [4]
GO:0005737_!_cytoplasm (C) IDA [3]
GO:0005737_!_cytoplasm (C) TAS [1]
GO:0006267_!_pre-replicative_complex_assembly (P) IPI [4]
GO:0006268_!_DNA_unwinding (P) TAS [2]
GO:0006270_!_DNA_replication_initiation (P) TAS [1]
GO:0042555_!_MCM_complex (C) IDA [5]

The contents of this box are automatically generated. You can help by adding information to the "Notes"



See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Dutta, A & Bell, SP (1997) Initiation of DNA replication in eukaryotic cells. Annu. Rev. Cell Dev. Biol. 13 293-332 PubMed GONUTS page SGD_REF:S000058275
  2. 2.0 2.1 Leatherwood, J (1998) Emerging mechanisms of eukaryotic DNA replication initiation. Curr. Opin. Cell Biol. 10 742-8 PubMed GONUTS page SGD_REF:S000058400
  3. 3.0 3.1 Nguyen, VQ et al. (2000) Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7. Curr. Biol. 10 195-205 PubMed GONUTS page SGD_REF:S000051716
  4. 4.0 4.1 Aparicio, OM et al. (1997) Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 91 59-69 PubMed GONUTS page SGD_REF:S000054350
  5. Davey, MJ et al. (2003) Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture. J. Biol. Chem. 278 4491-9 PubMed GONUTS page SGD_REF:S000072578