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SGD:CDC47

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Saccharomyces cerevisiae (baker's yeast)

CDC47:Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
Synonyms:YBR202W, MCM7
CDC47 on SGD

GO terms

GO:0003682_!_chromatin_binding (F) TAS [1]
GO:0004003_!_ATP-dependent_DNA_helicase_activity (F) TAS [2]
GO:0005524_!_ATP_binding (F) IDA [3]
GO:0005634_!_nucleus (C) IDA [4]
GO:0005656_!_pre-replicative_complex (C) IDA [5]
GO:0005737_!_cytoplasm (C) IDA [4]
GO:0005737_!_cytoplasm (C) TAS [1]
GO:0006267_!_pre-replicative_complex_assembly (P) IPI [5]
GO:0006268_!_DNA_unwinding (P) TAS [2]
GO:0006270_!_DNA_replication_initiation (P) TAS [1]
GO:0042555_!_MCM_complex (C) IDA [3]

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Notes

References

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  1. 1.0 1.1 1.2 Dutta, A & Bell, SP (1997) Initiation of DNA replication in eukaryotic cells. Annu. Rev. Cell Dev. Biol. 13 293-332 PubMed GONUTS page SGD_REF:S000058275
  2. 2.0 2.1 Leatherwood, J (1998) Emerging mechanisms of eukaryotic DNA replication initiation. Curr. Opin. Cell Biol. 10 742-8 PubMed GONUTS page SGD_REF:S000058400
  3. 3.0 3.1 Davey, MJ et al. (2003) Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture. J. Biol. Chem. 278 4491-9 PubMed GONUTS page SGD_REF:S000072578
  4. 4.0 4.1 Nguyen, VQ et al. (2000) Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7. Curr. Biol. 10 195-205 PubMed GONUTS page SGD_REF:S000051716
  5. 5.0 5.1 Aparicio, OM et al. (1997) Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 91 59-69 PubMed GONUTS page SGD_REF:S000054350
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