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SFV:POLS
Contents
| Species (Taxon ID) | Semliki forest virus (SFV). (11033) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Structural polyprotein
p130 Capsid protein Coat protein C p62 E3/E2 E3 protein Spike glycoprotein E3 E2 envelope glycoprotein Spike glycoprotein E2 6K protein E1 envelope glycoprotein Spike glycoprotein E1 | |
| External Links | ||
| UniProt | P03315 | |
| EMBL | Z48163 EU350586 AY112987 X04129 | |
| PIR | A93861 S42462 | |
| RefSeq | NP_463458.1 | |
| PDB | 1DYL 1I9W 1RER 1VCP 1VCQ 2ALA 2V33 | |
| PDBsum | 1DYL 1I9W 1RER 1VCP 1VCQ 2ALA 2V33 | |
| ProteinModelPortal | P03315 | |
| SMR | P03315 | |
| MEROPS | S03.001 | |
| TCDB | 1.G.4.1.1 | |
| GeneID | 922351 | |
| EvolutionaryTrace | P03315 | |
| Proteomes | UP000000570 | |
| GO | GO:0030430 GO:0020002 GO:0016021 GO:0039619 GO:0019031 GO:0055036 GO:0004252 GO:0005198 GO:0075512 GO:0039654 GO:0019062 | |
| Gene3D | 2.60.40.350 2.60.98.10 | |
| InterPro | IPR002548 IPR000936 IPR002533 IPR000336 IPR011998 IPR013754 IPR014756 IPR000930 IPR009003 | |
| Pfam | PF01589 PF00943 PF01563 PF00944 | |
| PRINTS | PR00798 | |
| SUPFAM | SSF50494 SSF56983 SSF81296 | |
| PROSITE | PS51690 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
Contributes to |
GO:0016021 |
integral component of membrane |
ECO:0000314 |
C |
Fig-1 shows how 6k makes the cell membrane more permeable by showing the location of tagged polypeptides in two different cells. One affected be the 6k protein and the other not. |
complete | ||||
| GO:0044174 |
host cell endosome |
ECO:0000314 |
C |
In figure 8b, the anti-El" antibody gave a punctal staining pattern which probably represented the endosomal structures |
complete | |||||
| GO:0044174 |
host cell endosome |
ECO:0000314 |
C |
In figure 8b, the anti-El" antibody gave a punctal staining pattern which probably represented the endosomal structures |
complete | |||||
| GO:0019068 |
virion assembly |
ECO:0000315 |
P |
in figure 2.(lane 8,9,11,12)). "This suggests that in the absence of E3, the spike glycoproteins do not form heterodimeric complexes at any time after synthesis"(involved in virus assembly). Lobigs,M. et at.(1990). |
complete | |||||
|
involved_in |
GO:0019068 |
virion assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044174 |
host cell endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005198 |
structural molecule activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019028 |
viral capsid |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0055036 |
virion membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039654 |
fusion of virus membrane with host endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0039619 |
T=4 icosahedral viral capsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075512 |
clathrin-dependent endocytosis of virus by host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019031 |
viral envelope |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019028 |
viral capsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019062 |
virion attachment to host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075509 |
endocytosis involved in viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039663 |
membrane fusion involved in viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0055036 |
virion membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
Many RNA viruses encode different proteins as a polyprotein that is processed by proteolysis into different final products. Unfortunately, at present, UniProt represents the proteins as parts ofa single polyprotein record. Therefore, when annotating, it is important to indicate which subproduct has the function being inferred.
References
See Help:References for how to manage references in GONUTS.
- ↑ Antoine, AF et al. (2007) The alphavirus 6K protein activates endogenous ionic conductances when expressed in Xenopus oocytes. J. Membr. Biol. 215 37-48 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Wahlberg, JM & Garoff, H (1992) Membrane fusion process of Semliki Forest virus. I: Low pH-induced rearrangement in spike protein quaternary structure precedes virus penetration into cells. J. Cell Biol. 116 339-48 PubMed GONUTS page
- ↑ 3.0 3.1 Lobigs, M et al. (1990) Function of Semliki Forest virus E3 peptide in virus assembly: replacement of E3 with an artificial signal peptide abolishes spike heterodimerization and surface expression of E1. J. Virol. 64 4346-55 PubMed GONUTS page
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