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SCHPO:SWI6

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) swi6
Protein Name(s) Chromatin-associated protein swi6
External Links
UniProt P40381
EMBL X71783
CU329670
PIR T39111
RefSeq NP_593449.1
PDB 1E0B
2RSO
PDBsum 1E0B
2RSO
ProteinModelPortal P40381
SMR P40381
BioGrid 278129
DIP DIP-35736N
IntAct P40381
MINT MINT-1571275
iPTMnet P40381
MaxQB P40381
EnsemblFungi [example_ID SPAC664.01c.1]
GeneID 2541633
KEGG spo:SPAC664.01c
EuPathDB FungiDB:SPAC664.01c
PomBase SPAC664.01c
InParanoid P40381
OMA GYLVKWK
OrthoDB EOG7Z3FHM
PhylomeDB P40381
EvolutionaryTrace P40381
NextBio 20802726
PRO PR:P40381
Proteomes UP000002485
GO GO:0034507
GO:0000781
GO:0000780
GO:0031934
GO:0044732
GO:0031618
GO:1990707
GO:0005634
GO:0005721
GO:0003682
GO:0035064
GO:0031492
GO:0031493
GO:0003723
GO:0034613
GO:0006338
GO:0030702
GO:1990141
GO:0030466
GO:0006348
GO:0072356
GO:0007535
GO:0007534
GO:0007533
GO:0007064
GO:0000070
GO:0071459
GO:0006351
InterPro IPR000953
IPR023780
IPR008251
IPR016197
IPR023779
Pfam PF00385
PF01393
SMART SM00298
SM00300
SUPFAM SSF54160
PROSITE PS00598
PS50013

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000070

mitotic sister chromatid segregation

PMID:7660126[1]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0000780

condensed nuclear chromosome, centromeric region

PMID:7660126[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000781

chromosome, telomeric region

PMID:7851795[2]

IMP: Inferred from Mutant Phenotype

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:21151114[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0003723

RNA binding

PMID:22683269[4]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0005515

protein binding

PMID:14625560[5]

IPI: Inferred from Physical Interaction

PomBase:SPBC776.12c

F

Seeded From UniProt

GO:0005515

protein binding

PMID:14625560[5]

IPI: Inferred from Physical Interaction

PomBase:SPCC550.13

F

Seeded From UniProt

GO:0005515

protein binding

PMID:14625560[5]

IPI: Inferred from Physical Interaction

UniProtKB:O59836

F

Seeded From UniProt

GO:0005515

protein binding

PMID:14625560[5]

IPI: Inferred from Physical Interaction

UniProtKB:P50582

F

Seeded From UniProt

GO:0005515

protein binding

PMID:14663140[6]

IPI: Inferred from Physical Interaction

PomBase:SPAC1142.03c

F

Seeded From UniProt

GO:0005515

protein binding

PMID:16168376[7]

IPI: Inferred from Physical Interaction

PomBase:SPAC30D11.13

F

Seeded From UniProt

GO:0005515

protein binding

PMID:17948055[8]

IPI: Inferred from Physical Interaction

PomBase:SPCC622.16c

F

Seeded From UniProt

GO:0005515

protein binding

PMID:20299449[9]

IPI: Inferred from Physical Interaction

PomBase:SPAC1834.04

F

Seeded From UniProt

GO:0005515

protein binding

PMID:20299449[9]

IPI: Inferred from Physical Interaction

PomBase:SPBC1105.11c

F

Seeded From UniProt

GO:0005515

protein binding

PMID:20299449[9]

IPI: Inferred from Physical Interaction

PomBase:SPBC8D2.04

F

Seeded From UniProt

GO:0005515

protein binding

PMID:20929775[10]

IPI: Inferred from Physical Interaction

PomBase:SPAC23C4.03

F

Seeded From UniProt

GO:0005515

protein binding

PMID:22990236[11]

IPI: Inferred from Physical Interaction

UniProtKB:O14139

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008251

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:16823372[12]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005720

nuclear heterochromatin

PMID:11069763[13]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005720

nuclear heterochromatin

PMID:11069763[13]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005721

pericentric heterochromatin

PMID:11553715[14]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0006338

chromatin remodeling

GO_REF:0000051

NAS: Non-traceable Author Statement

-

P

Seeded From UniProt

GO:0006348

chromatin silencing at telomere

PMID:7851795[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

GO:0007064

mitotic sister chromatid cohesion

PMID:11598266[15]

IGI: Inferred from Genetic Interaction

PomBase:SPCC338.17c

P

Seeded From UniProt

GO:0007533

mating type switching

PMID:1620099[16]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0007533

mating type switching

PMID:1783290[17]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0007534

gene conversion at mating-type locus

PMID:6587363[18]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0007535

donor selection

PMID:8375648[19]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0030466

chromatin silencing at silent mating-type cassette

PMID:1620099[16]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0030466

chromatin silencing at silent mating-type cassette

PMID:8138176[20]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0030702

chromatin silencing at centromere

PMID:7851795[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0031492

nucleosomal DNA binding

PMID:25332400[21]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0031493

nucleosomal histone binding

PMID:11242054[22]

IPI: Inferred from Physical Interaction

PomBase:SPBC1105.11c

F

Seeded From UniProt

GO:0031493

nucleosomal histone binding

PMID:11242054[22]

IPI: Inferred from Physical Interaction

PomBase:SPBC1105.11c

F

Seeded From UniProt

GO:0031493

nucleosomal histone binding

PMID:11242054[22]

IPI: Inferred from Physical Interaction

PomBase:SPBC1105.11c

F

Seeded From UniProt

GO:0031493

nucleosomal histone binding

PMID:25332400[21]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0031618

nuclear pericentric heterochromatin

PMID:20299449[9]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0031618

nuclear pericentric heterochromatin

PMID:20929775[10]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0031934

mating-type region heterochromatin

PMID:20929775[10]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0031934

mating-type region heterochromatin

PMID:7660126[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0034507

chromosome, centromeric outer repeat region

PMID:10766735[23]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0034613

cellular protein localization

PMID:11598266[15]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0034613

cellular protein localization

PMID:15615848[24]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0035064

methylated histone binding

PMID:22683269[4]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0035064

methylated histone binding

PMID:22727667[25]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0044732

mitotic spindle pole body

PMID:16823372[12]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0071459

protein localization to chromosome, centromeric region

PMID:20929775[10]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0071459

protein localization to chromosome, centromeric region

PMID:20929775[10]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0072356

chromosome passenger complex localization to kinetochore

GO_REF:0000001

NAS: Non-traceable Author Statement

-

P

Seeded From UniProt

GO:1990141

chromatin silencing at centromere outer repeat region

PMID:25274039[26]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:1990707

nuclear subtelomeric heterochromatin

PMID:20929775[10]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:1990707

nuclear subtelomeric heterochromatin

PMID:7660126[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0090053

positive regulation of chromatin silencing at centromere

PMID:19136623[27]

IMP: Inferred from Mutant Phenotype

P

silencing defects in ckb1Δ cells was comparable with that caused by disruption of other heterochromatic genes, swi6 (Fig. 1B).

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Ekwall, K et al. (1995) The chromodomain protein Swi6: a key component at fission yeast centromeres. Science 269 1429-31 PubMed GONUTS page
  2. 2.0 2.1 2.2 Allshire, RC et al. (1995) Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation. Genes Dev. 9 218-33 PubMed GONUTS page
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 Woolcock, KJ et al. (2011) Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe. Nat. Struct. Mol. Biol. 18 94-9 PubMed GONUTS page
  4. 4.0 4.1 Keller, C et al. (2012) HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts. Mol. Cell 47 215-27 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Bailis, JM et al. (2003) Hsk1-Dfp1 is required for heterochromatin-mediated cohesion at centromeres. Nat. Cell Biol. 5 1111-6 PubMed GONUTS page
  6. Akamatsu, Y et al. (2003) Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast. Proc. Natl. Acad. Sci. U.S.A. 100 15770-5 PubMed GONUTS page
  7. Shin, JA et al. (2005) SUMO modification is involved in the maintenance of heterochromatin stability in fission yeast. Mol. Cell 19 817-28 PubMed GONUTS page
  8. Trewick, SC et al. (2007) The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin. EMBO J. 26 4670-82 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Xhemalce, B & Kouzarides, T (2010) A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly. Genes Dev. 24 647-52 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 10.5 Yamagishi, Y et al. (2010) Two histone marks establish the inner centromere and chromosome bi-orientation. Science 330 239-43 PubMed GONUTS page
  11. Shim, YS et al. (2012) Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin. EMBO J. 31 4375-87 PubMed GONUTS page
  12. 12.0 12.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  13. 13.0 13.1 Pidoux, AL et al. (2000) Live analysis of lagging chromosomes during anaphase and their effect on spindle elongation rate in fission yeast. J. Cell. Sci. 113 Pt 23 4177-91 PubMed GONUTS page
  14. Kniola, B et al. (2001) The domain structure of centromeres is conserved from fission yeast to humans. Mol. Biol. Cell 12 2767-75 PubMed GONUTS page
  15. 15.0 15.1 Bernard, P et al. (2001) Requirement of heterochromatin for cohesion at centromeres. Science 294 2539-42 PubMed GONUTS page
  16. 16.0 16.1 Lorentz, A et al. (1992) The switching gene swi6 affects recombination and gene expression in the mating-type region of Schizosaccharomyces pombe. Mol. Gen. Genet. 233 436-42 PubMed GONUTS page
  17. Klar, AJ & Bonaduce, MJ (1991) swi6, a gene required for mating-type switching, prohibits meiotic recombination in the mat2-mat3 "cold spot" of fission yeast. Genetics 129 1033-42 PubMed GONUTS page
  18. Egel, R et al. (1984) Genes required for initiation and resolution steps of mating-type switching in fission yeast. Proc. Natl. Acad. Sci. U.S.A. 81 3481-5 PubMed GONUTS page
  19. Thon, G & Klar, AJ (1993) Directionality of fission yeast mating-type interconversion is controlled by the location of the donor loci. Genetics 134 1045-54 PubMed GONUTS page
  20. Ekwall, K & Ruusala, T (1994) Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast. Genetics 136 53-64 PubMed GONUTS page
  21. 21.0 21.1 Nishibuchi, G et al. (2014) N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity. Nucleic Acids Res. 42 12498-511 PubMed GONUTS page
  22. 22.0 22.1 22.2 Bannister, AJ et al. (2001) Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410 120-4 PubMed GONUTS page
  23. Partridge, JF et al. (2000) Distinct protein interaction domains and protein spreading in a complex centromere. Genes Dev. 14 783-91 PubMed GONUTS page
  24. Sugiyama, T et al. (2005) RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production. Proc. Natl. Acad. Sci. U.S.A. 102 152-7 PubMed GONUTS page
  25. Ishida, M et al. (2012) Intrinsic nucleic acid-binding activity of Chp1 chromodomain is required for heterochromatic gene silencing. Mol. Cell 47 228-41 PubMed GONUTS page
  26. Bayne, EH et al. (2014) A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast. Genome Biol. 15 481 PubMed GONUTS page
  27. Shimada, A et al. (2009) Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin. Genes Dev. 23 18-23 PubMed GONUTS page