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SCHPO:SWI6
Contents
| Species (Taxon ID) | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812) | |
| Gene Name(s) | swi6 | |
| Protein Name(s) | Chromatin-associated protein swi6 | |
| External Links | ||
| UniProt | P40381 | |
| EMBL | X71783 CU329670 | |
| PIR | T39111 | |
| RefSeq | NP_593449.1 | |
| PDB | 1E0B 2RSO | |
| PDBsum | 1E0B 2RSO | |
| ProteinModelPortal | P40381 | |
| SMR | P40381 | |
| BioGrid | 278129 | |
| DIP | DIP-35736N | |
| IntAct | P40381 | |
| MINT | P40381 | |
| STRING | 4896.SPAC664.01c.1 | |
| iPTMnet | P40381 | |
| MaxQB | P40381 | |
| PaxDb | P40381 | |
| PRIDE | P40381 | |
| EnsemblFungi | SPAC664.01c.1 | |
| GeneID | 2541633 | |
| KEGG | spo:SPAC664.01c | |
| EuPathDB | FungiDB:SPAC664.01c | |
| PomBase | SPAC664.01c | |
| InParanoid | P40381 | |
| OMA | SWVDEQD | |
| PhylomeDB | P40381 | |
| EvolutionaryTrace | P40381 | |
| PRO | PR:P40381 | |
| Proteomes | UP000002485 | |
| GO | GO:0034507 GO:0000781 GO:0000780 GO:0031934 GO:0000790 GO:0005720 GO:0031618 GO:1990707 GO:0005721 GO:0042802 GO:0035064 GO:0031492 GO:0031493 GO:0003723 GO:0006325 GO:0030702 GO:0030466 GO:0006348 GO:0031048 GO:0007534 GO:0007533 GO:0044820 GO:0033696 GO:0071459 | |
| CDD | cd00024 | |
| InterPro | IPR016197 IPR000953 IPR023780 IPR008251 IPR023779 | |
| Pfam | PF00385 PF01393 | |
| SMART | SM00298 SM00300 | |
| SUPFAM | SSF54160 | |
| PROSITE | PS00598 PS50013 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0090053 |
positive regulation of chromatin silencing at centromere |
ECO:0000315 |
P |
silencing defects in ckb1Δ cells was comparable with that caused by disruption of other heterochromatic genes, swi6 (Fig. 1B). |
complete | |||||
|
part_of |
GO:1990707 |
nuclear subtelomeric heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1990707 |
nuclear subtelomeric heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071459 |
protein localization to chromosome, centromeric region |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(PomBase:SPAC23C4.03) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071459 |
protein localization to chromosome, centromeric region |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(PomBase:SPAC110.02) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0044820 |
mitotic telomere tethering at nuclear periphery |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035064 |
methylated histone binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035064 |
methylated histone binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034507 |
chromosome, centromeric outer repeat region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
exists_during:(GO:0098764) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034507 |
chromosome, centromeric outer repeat region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033696 |
negative regulation of extent of heterochromatin assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031934 |
mating-type region heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031934 |
mating-type region heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031934 |
mating-type region heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
exists_during:(GO:0098764) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031934 |
mating-type region heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031618 |
nuclear pericentric heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031618 |
nuclear pericentric heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031618 |
nuclear pericentric heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001799) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031618 |
nuclear pericentric heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001798) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031493 |
nucleosomal histone binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
PomBase:SPBC1105.11c |
F |
has_direct_input:(PR:000027604) |
Seeded From UniProt |
complete | |
|
enables |
GO:0031493 |
nucleosomal histone binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
PomBase:SPBC1105.11c |
F |
has_direct_input:(PR:000027593) |
Seeded From UniProt |
complete | |
|
enables |
GO:0031493 |
nucleosomal histone binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
PomBase:SPBC1105.11c |
F |
has_direct_input:(PR:000027578) |
Seeded From UniProt |
complete | |
|
enables |
GO:0031493 |
nucleosomal histone binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031492 |
nucleosomal DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031048 |
chromatin silencing by small RNA |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030702 |
chromatin silencing at centromere |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030702 |
chromatin silencing at centromere |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030466 |
chromatin silencing at silent mating-type cassette |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030466 |
chromatin silencing at silent mating-type cassette |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030466 |
chromatin silencing at silent mating-type cassette |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007534 |
gene conversion at mating-type locus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007533 |
mating type switching |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006348 |
chromatin silencing at telomere |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006348 |
chromatin silencing at telomere |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005721 |
pericentric heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001795) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001789) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0000624) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0000624) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0000577) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001799) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001798) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001796) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001789) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001637) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001263) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001217) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0000624) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0000336) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0000296) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0000286) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0000253) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0000204) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000780 |
condensed nuclear chromosome, centromeric region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000781 |
chromosome, telomeric region |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0006348 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000781 |
chromosome, telomeric region |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0006348 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Shimada, A et al. (2009) Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin. Genes Dev. 23 18-23 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Ekwall, K et al. (1995) The chromodomain protein Swi6: a key component at fission yeast centromeres. Science 269 1429-31 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Yamagishi, Y et al. (2010) Two histone marks establish the inner centromere and chromosome bi-orientation. Science 330 239-43 PubMed GONUTS page
- ↑ Reyes, C et al. (2015) Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction. J. Cell Biol. 208 713-27 PubMed GONUTS page
- ↑ Ishida, M et al. (2012) Intrinsic nucleic acid-binding activity of Chp1 chromodomain is required for heterochromatic gene silencing. Mol. Cell 47 228-41 PubMed GONUTS page
- ↑ 6.0 6.1 Keller, C et al. (2012) HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts. Mol. Cell 47 215-27 PubMed GONUTS page
- ↑ 7.0 7.1 Kawashima, SA et al. (2010) Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin. Science 327 172-7 PubMed GONUTS page
- ↑ Partridge, JF et al. (2000) Distinct protein interaction domains and protein spreading in a complex centromere. Genes Dev. 14 783-91 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Stunnenberg, R et al. (2015) H3K9 methylation extends across natural boundaries of heterochromatin in the absence of an HP1 protein. EMBO J. 34 2789-803 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Nakayama, J et al. (2001) Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292 110-3 PubMed GONUTS page
- ↑ Xhemalce, B & Kouzarides, T (2010) A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly. Genes Dev. 24 647-52 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Bannister, AJ et al. (2001) Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410 120-4 PubMed GONUTS page
- ↑ 13.0 13.1 Nishibuchi, G et al. (2014) N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity. Nucleic Acids Res. 42 12498-511 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 Motamedi, MR et al. (2008) HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Mol. Cell 32 778-90 PubMed GONUTS page
- ↑ 15.0 15.1 Allshire, RC et al. (1995) Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation. Genes Dev. 9 218-33 PubMed GONUTS page
- ↑ Ekwall, K & Ruusala, T (1994) Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast. Genetics 136 53-64 PubMed GONUTS page
- ↑ 17.0 17.1 Lorentz, A et al. (1992) The switching gene swi6 affects recombination and gene expression in the mating-type region of Schizosaccharomyces pombe. Mol. Gen. Genet. 233 436-42 PubMed GONUTS page
- ↑ Egel, R et al. (1984) Genes required for initiation and resolution steps of mating-type switching in fission yeast. Proc. Natl. Acad. Sci. U.S.A. 81 3481-5 PubMed GONUTS page
- ↑ Singh, J et al. (1998) A novel function of the DNA repair gene rhp6 in mating-type silencing by chromatin remodeling in fission yeast. Mol. Cell. Biol. 18 5511-22 PubMed GONUTS page
- ↑ Kniola, B et al. (2001) The domain structure of centromeres is conserved from fission yeast to humans. Mol. Biol. Cell 12 2767-75 PubMed GONUTS page
- ↑ 21.0 21.1 Pidoux, AL et al. (2000) Live analysis of lagging chromosomes during anaphase and their effect on spindle elongation rate in fission yeast. J. Cell. Sci. 113 Pt 23 4177-91 PubMed GONUTS page
- ↑ 22.00 22.01 22.02 22.03 22.04 22.05 22.06 22.07 22.08 22.09 22.10 22.11 22.12 Woolcock, KJ et al. (2011) Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe. Nat. Struct. Mol. Biol. 18 94-9 PubMed GONUTS page
- ↑ Canzio, D et al. (2013) A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature 496 377-81 PubMed GONUTS page
- ↑ Yamagishi, Y et al. (2008) Heterochromatin links to centromeric protection by recruiting shugoshin. Nature 455 251-5 PubMed GONUTS page
- ↑ Akamatsu, Y et al. (2003) Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast. Proc. Natl. Acad. Sci. U.S.A. 100 15770-5 PubMed GONUTS page
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