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SCHPO:SET1

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) EMBL:CAB41652.1} (synonyms: kmt2)
Protein Name(s) Histone-lysine N-methyltransferase, H3 lysine-4 specific

COMPASS component set1 Lysine N-methyltransferase 2 SET domain-containing protein 1 Set1 complex component set1 Set1C component set1 Spset1

External Links
UniProt Q9Y7R4
EMBL CU329672
PIR T41282
RefSeq NP_587812.1
ProteinModelPortal Q9Y7R4
BioGrid 275345
IntAct Q9Y7R4
MINT MINT-4718299
STRING 4896.SPCC306.04c-1
MaxQB Q9Y7R4
EnsemblFungi [example_ID SPCC306.04c.1]
GeneID 2538762
KEGG spo:SPCC306.04c
PomBase SPCC306.04c
eggNOG COG2940
InParanoid Q9Y7R4
KO K11422
OMA CGAPGCK
OrthoDB EOG7P8PH3
PhylomeDB Q9Y7R4
NextBio 20799946
PRO PR:Q9Y7R4
GO GO:0005737
GO:0000790
GO:0048188
GO:0042800
GO:0018024
GO:0000166
GO:0003723
GO:0006338
GO:0051568
GO:0044773
GO:0000723
Gene3D 3.30.70.330
InterPro IPR024657
IPR017111
IPR012677
IPR003616
IPR000504
IPR024636
IPR001214
Pfam PF11764
PF00076
PF00856
PF11767
PIRSF PIRSF037104
SMART SM00508
SM00360
SM00317
PROSITE PS50868
PS50102
PS51572
PS50280

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000077

DNA damage checkpoint

PMID:12589755[1]

IGI: Inferred from Genetic Interaction

PomBase:SPBC342.05

P

Seeded From UniProt

GO:0000166

nucleotide binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012677

F

Seeded From UniProt

GO:0000723

telomere maintenance

PMID:12589755[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0000790

nuclear chromatin

GO_REF:0000001

NAS: Non-traceable Author Statement

C

Seeded From UniProt

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000504

F

Seeded From UniProt

GO:0003723

RNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0694

F

Seeded From UniProt

GO:0005515

protein binding

PMID:18957202[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q9HDV4

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0005694

chromosome

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0158

C

Seeded From UniProt

GO:0005694

chromosome

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:16823372[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0006281

DNA repair

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0234

P

Seeded From UniProt

GO:0006338

chromatin remodeling

GO_REF:0000001

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P38827

P

Seeded From UniProt

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0227

P

Seeded From UniProt

GO:0008168

methyltransferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0489

F

Seeded From UniProt

GO:0016568

chromatin modification

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0156

P

Seeded From UniProt

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015722
InterPro:IPR017111

F

Seeded From UniProt

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.1.1.43

F

Seeded From UniProt

GO:0018024

histone-lysine N-methyltransferase activity

PMID:12193658[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0032259

methylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0489

P

Seeded From UniProt

GO:0034968

histone lysine methylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017111

P

Seeded From UniProt

GO:0042800

histone methyltransferase activity (H3-K4 specific)

PMID:12193658[4]

TAS: Traceable Author Statement

F

Seeded From UniProt

GO:0048188

Set1C/COMPASS complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017111

C

Seeded From UniProt

GO:0048188

Set1C/COMPASS complex

PMID:12488447[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0051568

histone H3-K4 methylation

PMID:12193658[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

NOT

GO:0006342

chromatin silencing

PMID:12193658[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Kanoh, J et al. (2003) The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway. J. Mol. Biol. 326 1081-94 PubMed GONUTS page
  2. Li, F et al. (2008) Lid2 is required for coordinating H3K4 and H3K9 methylation of heterochromatin and euchromatin. Cell 135 272-83 PubMed GONUTS page
  3. Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Noma, K & Grewal, SI (2002) Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast. Proc. Natl. Acad. Sci. U.S.A. 99 Suppl 4 16438-45 PubMed GONUTS page
  5. Roguev, A et al. (2003) High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts. J. Biol. Chem. 278 8487-93 PubMed GONUTS page