SCHPO:RAD3

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	rad3
Protein Name(s)	Protein kinase rad3 DNA repair protein rad3
External Links
UniProt	Q02099
EMBL	Y09076 U76307 CU329671 X63544
PIR	T39911
RefSeq	NP_595357.1
ProteinModelPortal	Q02099
BioGrid	277242
IntAct	Q02099
STRING	4896.SPBC216.05.1
iPTMnet	Q02099
MaxQB	Q02099
PaxDb	Q02099
PRIDE	Q02099
EnsemblFungi	SPBC216.05.1
GeneID	2540719
KEGG	spo:SPBC216.05
EuPathDB	FungiDB:SPBC216.05
PomBase	SPBC216.05
InParanoid	Q02099
KO	K06640
OMA	WMLLPHF
PhylomeDB	Q02099
PRO	PR:Q02099
Proteomes	UP000002485
GO	GO:0070310 GO:0000781 GO:0005829 GO:0000790 GO:0000228 GO:0005730 GO:0005634 GO:1990421 GO:0005524 GO:0004672 GO:0004674 GO:0071897 GO:0000077 GO:0006975 GO:0006281 GO:1990853 GO:0031573 GO:0051598 GO:0033314 GO:0007095 GO:0045739 GO:1904514 GO:1904291 GO:0070198 GO:0000723
Gene3D	1.10.1070.11
InterPro	IPR003152 IPR011009 IPR000403 IPR036940 IPR018936 IPR003151 IPR014009 IPR011990 IPR012993
Pfam	PF02259 PF02260 PF00454 PF08064
SMART	SM01343 SM00146 SM00802
SUPFAM	SSF48452 SSF56112
PROSITE	PS51189 PS51190 PS00916 PS50290

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005829	cytosol		ECO:0000314			C		Source: GeneDB_Spombe	Missing: reference
	GO:0000228	nuclear chromosome		ECO:0000314			C		Source: GeneDB_Spombe	Missing: reference
	GO:0043234	protein complex		ECO:0000303			C		Source: GeneDB_Spombe	Missing: reference
	GO:0004674	protein serine/threonine kinase activity		ECO:0000314			F		Source: GeneDB_Spombe	Missing: reference
	GO:0031573	intra-S DNA damage checkpoint		ECO:0000314			P		Source: GeneDB_Spombe	Missing: reference
	GO:0007131	reciprocal meiotic recombination		ECO:0000315			P		Source: GeneDB_Spombe	Missing: reference
	GO:0004672	protein kinase activity	PMID:22302936^[1]	ECO:0000315			F		Figure 2A,E show that mutants without Rad3 were unable to phosphorylate Thr93 of Ccq1 and those with Rad3 were able to phosphorylate Thr93 of Ccq1.	complete CACAO 4394
enables	GO:0004672	protein kinase activity	PMID:22302936^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1990853	histone H2A SQE motif phosphorylation	PMID:15226425^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990421	subtelomeric heterochromatin	PMID:12196391^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904514	positive regulation of initiation of premeiotic DNA replication	PMID:21084840^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904291	positive regulation of mitotic DNA damage checkpoint	PMID:15226425^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070310	ATR-ATRIP complex	PMID:10559981^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070198	protein localization to chromosome, telomeric region	PMID:20140190^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC6B1.09c	P	has_input:(PomBase:SPCC23B6.03c)	Seeded From UniProt	complete
involved_in	GO:0051598	meiotic recombination checkpoint	PMID:29123917^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:15226425^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0005515	protein binding	PMID:15173168^[8]	ECO:0000021		GeneDB_Spombe:SPAC694.06c	F			complete
involved_in	GO:0033315	meiotic G2/MI DNA replication checkpoint	PMID:10521402^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033314	mitotic DNA replication checkpoint	PMID:11313465^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031573	intra-S DNA damage checkpoint	PMID:19037101^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031573	intra-S DNA damage checkpoint	PMID:1594599^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0005829	cytosol	PMID:16823372^[13]	ECO:0000314			C			complete
involved_in	GO:0031573	intra-S DNA damage checkpoint	PMID:12032307^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007095	mitotic G2 DNA damage checkpoint	PMID:1594599^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006975	DNA damage induced protein phosphorylation	PMID:15226425^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:1594599^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0007131	reciprocal meiotic recombination	PMID:12628934^[15]	ECO:0000315			P			complete
part_of	GO:0005829	cytosol	PMID:16823372^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0007346	regulation of mitotic cell cycle	GO_REF:0000001	ECO:0000303			P			complete
part_of	GO:0005730	nucleolus	PMID:18180284^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16618806^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(PomBase:SPAC694.06c) part_of:(GO:0072443)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21099360^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:29035) has_direct_input:(PomBase:SPAC694.06c)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21084840^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	inhibited_by:(CHEBI:52289)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21084840^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPCC18B5.11c)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21084840^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	happens_during:(GO:0051328) has_direct_input:(PomBase:SPAC14C4.03) part_of:(GO:1904514)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:14585996^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPAC694.06c)	Seeded From UniProt	complete
	GO:0031573	intra-S DNA damage checkpoint	PMID:12032307^[14]	ECO:0000315			P			complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11553781^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPCC1259.13) part_of:(GO:0072434)	Seeded From UniProt	complete
	GO:0031573	intra-S DNA damage checkpoint	PMID:19037101^[11]	ECO:0000314			P			complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11313465^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
	GO:0043234	protein complex	GO_REF:0000001	ECO:0000303			C			complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10512862^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPCC1259.13)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:8978690^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21945095^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0031297) part_of:(GO:0043596)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:17531813^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0033314)	Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	PMID:20140190^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:20140190^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC6B1.09c	P		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:12196391^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000228	nuclear chromosome	PMID:8843195^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0045035 FB:FBgn0053554 MGI:MGI:104779 MGI:MGI:1928394 PANTHER:PTN000124197 RGD:1593265 RGD:68371 SGD:S000000340 SGD:S000001141 SGD:S000003827 UniProtKB:P78527 UniProtKB:Q13315 UniProtKB:Q96Q15 UniProtKB:Q9FR53 UniProtKB:Q9Y4A5 WB:WBGene00000226 WB:WBGene00007028	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001673376 PomBase:SPBC216.05 UniProtKB:Q13535	F		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004367 PANTHER:PTN001673376 PomBase:SPBC216.05 SGD:S000000340	P		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004367 MGI:MGI:108028 PANTHER:PTN001673376 UniProtKB:C8VB89 UniProtKB:Q13535 WB:WBGene00000226	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012993	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0237	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yamazaki, H et al. (2012) Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast. Genes Dev. 26 241-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Nakamura, TM et al. (2004) Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast. Mol. Cell. Biol. 24 6215-30 PubMed GONUTS page
↑ ^3.0 ^3.1 Nakamura, TM et al. (2002) Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics 161 1437-52 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Tougan, T et al. (2010) The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe. Cell Cycle 9 4688-702 PubMed GONUTS page
↑ Edwards, RJ et al. (1999) A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins. Nat. Cell Biol. 1 393-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Subramanian, L & Nakamura, TM (2010) A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast. PLoS Genet. 6 e1000839 PubMed GONUTS page
↑ Moiseeva, V et al. (2017) The telomere bouquet facilitates meiotic prophase progression and exit in fission yeast. Cell Discov 3 17041 PubMed GONUTS page
↑ Tanaka, K & Russell, P (2004) Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1. J. Biol. Chem. 279 32079-86 PubMed GONUTS page
↑ Murakami, H & Nurse, P (1999) Meiotic DNA replication checkpoint control in fission yeast. Genes Dev. 13 2581-93 PubMed GONUTS page
↑ ^10.0 ^10.1 Tanaka, K et al. (2001) Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1. Mol. Cell. Biol. 21 3398-404 PubMed GONUTS page
↑ ^11.0 ^11.1 Willis, N & Rhind, N (2009) Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint. Mol. Biol. Cell 20 819-33 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Jimenez, G et al. (1992) The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair. Proc. Natl. Acad. Sci. U.S.A. 89 4952-6 PubMed GONUTS page
↑ ^13.0 ^13.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ ^14.0 ^14.1 Marchetti, MA et al. (2002) A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway. Proc. Natl. Acad. Sci. U.S.A. 99 7472-7 PubMed GONUTS page
↑ Prudden, J et al. (2003) Pathway utilization in response to a site-specific DNA double-strand break in fission yeast. EMBO J. 22 1419-30 PubMed GONUTS page
↑ Bailis, JM et al. (2008) Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability. Mol. Cell. Biol. 28 1724-38 PubMed GONUTS page
↑ Xu, YJ et al. (2006) Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast. Genes Dev. 20 990-1003 PubMed GONUTS page
↑ Matsumoto, S et al. (2010) Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast. Cell Cycle 9 4627-37 PubMed GONUTS page
↑ Zhao, H et al. (2003) Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast. Mol. Cell. Biol. 23 8395-403 PubMed GONUTS page
↑ Lopez-Girona, A et al. (2001) Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast. Proc. Natl. Acad. Sci. U.S.A. 98 11289-94 PubMed GONUTS page
↑ Chapman, CR et al. (1999) Requirement of sequences outside the conserved kinase domain of fission yeast Rad3p for checkpoint control. Mol. Biol. Cell 10 3223-38 PubMed GONUTS page
↑ Bentley, NJ et al. (1996) The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J. 15 6641-51 PubMed GONUTS page
↑ Taylor, M et al. (2011) Mcm10 interacts with Rad4/Cut5(TopBP1) and its association with origins of DNA replication is dependent on Rad4/Cut5(TopBP1). DNA Repair (Amst.) 10 1154-63 PubMed GONUTS page
↑ Hermand, D & Nurse, P (2007) Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin. Mol. Cell 26 553-63 PubMed GONUTS page
↑ Keegan, KS et al. (1996) The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev. 10 2423-37 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22302936-1] 1.0 ^1.1 Yamazaki, H et al. (2012) Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast. Genes Dev. 26 241-6 PubMed GONUTS page

[PMID:15226425-2] 2.0 ^2.1 ^2.2 ^2.3 Nakamura, TM et al. (2004) Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast. Mol. Cell. Biol. 24 6215-30 PubMed GONUTS page

[PMID:12196391-3] 3.0 ^3.1 Nakamura, TM et al. (2002) Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics 161 1437-52 PubMed GONUTS page

[PMID:21084840-4] 4.0 ^4.1 ^4.2 ^4.3 Tougan, T et al. (2010) The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe. Cell Cycle 9 4688-702 PubMed GONUTS page

[PMID:10559981-5] Edwards, RJ et al. (1999) A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins. Nat. Cell Biol. 1 393-8 PubMed GONUTS page

[PMID:20140190-6] 6.0 ^6.1 ^6.2 Subramanian, L & Nakamura, TM (2010) A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast. PLoS Genet. 6 e1000839 PubMed GONUTS page

[PMID:29123917-7] Moiseeva, V et al. (2017) The telomere bouquet facilitates meiotic prophase progression and exit in fission yeast. Cell Discov 3 17041 PubMed GONUTS page

[PMID:15173168-8] Tanaka, K & Russell, P (2004) Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1. J. Biol. Chem. 279 32079-86 PubMed GONUTS page

[PMID:10521402-9] Murakami, H & Nurse, P (1999) Meiotic DNA replication checkpoint control in fission yeast. Genes Dev. 13 2581-93 PubMed GONUTS page

[PMID:11313465-10] 10.0 ^10.1 Tanaka, K et al. (2001) Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1. Mol. Cell. Biol. 21 3398-404 PubMed GONUTS page

[PMID:19037101-11] 11.0 ^11.1 Willis, N & Rhind, N (2009) Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint. Mol. Biol. Cell 20 819-33 PubMed GONUTS page

[PMID:1594599-12] 12.0 ^12.1 ^12.2 Jimenez, G et al. (1992) The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair. Proc. Natl. Acad. Sci. U.S.A. 89 4952-6 PubMed GONUTS page

[PMID:16823372-13] 13.0 ^13.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:12032307-14] 14.0 ^14.1 Marchetti, MA et al. (2002) A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway. Proc. Natl. Acad. Sci. U.S.A. 99 7472-7 PubMed GONUTS page

[PMID:12628934-15] Prudden, J et al. (2003) Pathway utilization in response to a site-specific DNA double-strand break in fission yeast. EMBO J. 22 1419-30 PubMed GONUTS page

[PMID:18180284-16] Bailis, JM et al. (2008) Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability. Mol. Cell. Biol. 28 1724-38 PubMed GONUTS page

[PMID:16618806-17] Xu, YJ et al. (2006) Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast. Genes Dev. 20 990-1003 PubMed GONUTS page

[PMID:21099360-18] Matsumoto, S et al. (2010) Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast. Cell Cycle 9 4627-37 PubMed GONUTS page

[PMID:14585996-19] Zhao, H et al. (2003) Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast. Mol. Cell. Biol. 23 8395-403 PubMed GONUTS page

[PMID:11553781-20] Lopez-Girona, A et al. (2001) Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast. Proc. Natl. Acad. Sci. U.S.A. 98 11289-94 PubMed GONUTS page

[PMID:10512862-21] Chapman, CR et al. (1999) Requirement of sequences outside the conserved kinase domain of fission yeast Rad3p for checkpoint control. Mol. Biol. Cell 10 3223-38 PubMed GONUTS page

[PMID:8978690-22] Bentley, NJ et al. (1996) The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J. 15 6641-51 PubMed GONUTS page

[PMID:21945095-23] Taylor, M et al. (2011) Mcm10 interacts with Rad4/Cut5(TopBP1) and its association with origins of DNA replication is dependent on Rad4/Cut5(TopBP1). DNA Repair (Amst.) 10 1154-63 PubMed GONUTS page

[PMID:17531813-24] Hermand, D & Nurse, P (2007) Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin. Mol. Cell 26 553-63 PubMed GONUTS page

[PMID:8843195-25] Keegan, KS et al. (1996) The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev. 10 2423-37 PubMed GONUTS page

[PMID:21873635-26] 26.0 ^26.1 ^26.2 ^26.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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SCHPO:RAD3

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