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SCHPO:PABP

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) pab1 (synonyms: pabp)
Protein Name(s) Polyadenylate-binding protein, cytoplasmic and nuclear

PABP Poly(A)-binding protein Polyadenylate tail-binding protein

External Links
UniProt P31209
EMBL CU329670
M64603
PIR T38950
RefSeq NP_593377.1
ProteinModelPortal P31209
SMR P31209
BioGrid 278007
IntAct P31209
STRING 4896.SPAC57A7.04c.1
iPTMnet P31209
MaxQB P31209
PaxDb P31209
PRIDE P31209
EnsemblFungi SPAC57A7.04c.1
GeneID 2541505
KEGG spo:SPAC57A7.04c
EuPathDB FungiDB:SPAC57A7.04c
PomBase SPAC57A7.04c
HOGENOM HOG000217922
InParanoid P31209
KO K13126
OMA RNQIRMQ
PhylomeDB P31209
Reactome R-SPO-156827
R-SPO-975956
R-SPO-975957
PRO PR:P31209
Proteomes UP000002485
GO GO:0005737
GO:0010494
GO:0005829
GO:0005634
GO:0071014
GO:1990904
GO:0003730
GO:0008143
GO:0008266
GO:0003723
GO:0006406
GO:0006397
GO:0006417
Gene3D 3.30.70.330
InterPro IPR012677
IPR036053
IPR006515
IPR002004
IPR035979
IPR000504
IPR003954
Pfam PF00658
PF00076
SMART SM00517
SM00360
SM00361
SUPFAM SSF54928
SSF63570
TIGRFAMs TIGR01628
PROSITE PS51309
PS50102

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1904690

positive regulation of cytoplasmic translational initiation

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000000967

P

Seeded From UniProt

complete

involved_in

GO:1901919

positive regulation of exoribonuclease activity

PMID:29932902[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901918

negative regulation of exoribonuclease activity

PMID:29932902[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0071014

post-mRNA release spliceosomal complex

PMID:24442611[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060212

negative regulation of nuclear-transcribed mRNA poly(A) tail shortening

PMID:30601114[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060211

regulation of nuclear-transcribed mRNA poly(A) tail shortening

PMID:29932902[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031124

mRNA 3'-end processing

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000000967

P

Seeded From UniProt

complete

part_of

GO:0010494

cytoplasmic stress granule

PMID:22172946[4]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0034605)

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:12112233[5]

ECO:0000314

C

complete

part_of

GO:0010494

cytoplasmic stress granule

PMID:21098141[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008143

poly(A) binding

PMID:29932902[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16823372[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:12112233[5]

ECO:0000314

C

complete

part_of

GO:0005737

cytoplasm

PMID:25543137[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0265297
PANTHER:PTN002768817
UniProtKB:P11940
UniProtKB:Q13310

C

Seeded From UniProt

complete

part_of

GO:0010494

cytoplasmic stress granule

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000610046
PomBase:SPAC57A7.04c
SGD:S000000967
UniProtKB:P11940
UniProtKB:Q13310

C

Seeded From UniProt

complete

enables

GO:0008266

poly(U) RNA binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0264270
PANTHER:PTN000610044
UniProtKB:P11940
UniProtKB:Q13310
UniProtKB:Q6XE24

F

Seeded From UniProt

complete

enables

GO:0008143

poly(A) binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000610044
SGD:S000000967
TAIR:locus:2013011
UniProtKB:P11940
UniProtKB:Q13310
UniProtKB:Q6XE24
UniProtKB:Q9H361

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000610044
TAIR:locus:2012161
TAIR:locus:2013011
TAIR:locus:2058573
UniProtKB:P11940
UniProtKB:P29558
UniProtKB:Q13310
UniProtKB:Q9H361

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0264270
FB:FBgn0265297
MGI:MGI:1349722
PANTHER:PTN000610044
PomBase:SPAC57A7.04c
PomBase:SPBC29A10.02
SGD:S000000967
SGD:S000003969
UniProtKB:Q13310
UniProtKB:Q6XE24
WB:WBGene00003902
WB:WBGene00006331

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000610044
PomBase:SPBC29A10.02
SGD:S000000967
TAIR:locus:2013011
UniProtKB:P11940
UniProtKB:Q13310

C

Seeded From UniProt

complete

enables

GO:0003730

mRNA 3'-UTR binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0264270
FB:FBgn0265297
MGI:MGI:2444477
PANTHER:PTN000610044
UniProtKB:P11940
WB:WBGene00006331

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000114
FB:FBgn0264001
MGI:MGI:1926034
PANTHER:PTN002768817
PomBase:SPAC1610.03c
RGD:68347
SGD:S000005846
UniProtKB:O04425
UniProtKB:P0DJD4
UniProtKB:P11940
UniProtKB:Q5SZQ8
UniProtKB:Q8IDB7
UniProtKB:Q8IUH3
UniProtKB:Q92879

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000504
InterPro:IPR003954
InterPro:IPR035979

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002004
InterPro:IPR006515
InterPro:IPR036053

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

involved_in

GO:0051028

mRNA transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0509

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006417

regulation of translation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0810

P

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Webster, MW et al. (2018) mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases. Mol. Cell 70 1089-1100.e8 PubMed GONUTS page
  2. ↑ Chen, W et al. (2014) Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes. RNA 20 308-20 PubMed GONUTS page
  3. ↑ Webster, MW et al. (2019) RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not. Elife 8 PubMed GONUTS page
  4. ↑ Morita, T et al. (2012) The stress granule protein Vgl1 and poly(A)-binding protein Pab1 are required for doxorubicin resistance in the fission yeast Schizosaccharomyces pombe. Biochem. Biophys. Res. Commun. 417 399-403 PubMed GONUTS page
  5. ↑ 5.0 5.1 Thakurta, AG et al. (2002) Schizosaccharomyces pombe spPABP, a homologue of Saccharomyces cerevisiae Pab1p, is a non-essential, shuttling protein that facilitates mRNA export. Yeast 19 803-10 PubMed GONUTS page
  6. ↑ Nilsson, D & Sunnerhagen, P (2011) Cellular stress induces cytoplasmic RNA granules in fission yeast. RNA 17 120-33 PubMed GONUTS page
  7. ↑ Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  8. ↑ Oberti, D et al. (2015) Dicer and Hsp104 function in a negative feedback loop to confer robustness to environmental stress. Cell Rep 10 47-61 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 9.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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