SCHPO:MSH2

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	msh2
Protein Name(s)	DNA mismatch repair protein msh2
External Links
UniProt	O74773
EMBL	AJ006948 CU329671
PIR	T43699
RefSeq	XP_001713136.1
ProteinModelPortal	O74773
SMR	O74773
BioGrid	277219
STRING	4896.SPBC19G7.01c.1
MaxQB	O74773
PaxDb	O74773
PRIDE	O74773
EnsemblFungi	SPBC19G7.01c.1
EuPathDB	FungiDB:SPBC19G7.01c
PomBase	SPBC19G7.01c
HOGENOM	HOG000196498
InParanoid	O74773
OMA	IPDILML
PhylomeDB	O74773
Reactome	R-SPO-5358565 R-SPO-5358606
PRO	PR:O74773
Proteomes	UP000002485
GO	GO:0005829 GO:0032300 GO:0032301 GO:0032302 GO:0000228 GO:0005634 GO:0005524 GO:0016887 GO:0003684 GO:0008094 GO:0000406 GO:0000400 GO:0030983 GO:0000403 GO:0007534 GO:0043570 GO:0006298 GO:0045910 GO:0006301
Gene3D	3.30.420.110 3.40.1170.10
InterPro	IPR011184 IPR007695 IPR000432 IPR007861 IPR007696 IPR016151 IPR036187 IPR007860 IPR032642 IPR036678 IPR027417
PANTHER	PTHR11361:SF35
Pfam	PF01624 PF05188 PF05192 PF05190 PF00488
PIRSF	PIRSF005813
SMART	SM00534 SM00533
SUPFAM	SSF48334 SSF52540
PROSITE	PS00486

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0043570	maintenance of DNA repeat elements	PMID:11333219^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
contributes_to	GO:0032138	single base insertion or deletion binding	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000005450	F	Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000005450	F	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000005450	F	Seeded From UniProt	complete
involved_in	GO:0007534	gene conversion at mating-type locus	PMID:6587363^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:9871115^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC29A10.05	P	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:9871115^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPAC19G12.02c	P	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:9858548^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16823372^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16823372^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000005450	F	Seeded From UniProt	complete
enables	GO:0000406	double-strand/single-strand DNA junction binding	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000005450	F	Seeded From UniProt	complete
contributes_to	GO:0000404	heteroduplex DNA loop binding	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000005450	F	Seeded From UniProt	complete
enables	GO:0000403	Y-form DNA binding	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000005450	F	Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000005450	F	Seeded From UniProt	complete
part_of	GO:0000228	nuclear chromosome	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000005450	C	Seeded From UniProt	complete
involved_in	GO:0045910	negative regulation of DNA recombination	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 TAIR:locus:2095097 UniProtKB:P43246	P	Seeded From UniProt	complete
involved_in	GO:0043570	maintenance of DNA repeat elements	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015546 PANTHER:PTN000145640 PomBase:SPBC19G7.01c UniProtKB:P43246 WB:WBGene00003418 ZFIN:ZDB-GENE-040426-2932	P	Seeded From UniProt	complete
contributes_to	GO:0032405	MutLalpha complex binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145640 UniProtKB:P43246	F	Seeded From UniProt	complete
contributes_to	GO:0032357	oxidized purine DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145640 UniProtKB:P43246	F	Seeded From UniProt	complete
part_of	GO:0032302	MutSbeta complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145640 SGD:S000005450 UniProtKB:P43246	C	Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 SGD:S000005450 UniProtKB:P43246	C	Seeded From UniProt	complete
part_of	GO:0032300	mismatch repair complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779	C	Seeded From UniProt	complete
contributes_to	GO:0032181	dinucleotide repeat insertion binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145640 UniProtKB:P43246	F	Seeded From UniProt	complete
contributes_to	GO:0032143	single thymine insertion binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145640 UniProtKB:P43246	F	Seeded From UniProt	complete
contributes_to	GO:0032142	single guanine insertion binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145640 UniProtKB:P43246	F	Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 SGD:S000005450 UniProtKB:P43246 ZFIN:ZDB-GENE-040426-2932	F	Seeded From UniProt	complete
contributes_to	GO:0030983	mismatched DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 MGI:MGI:1343961 PANTHER:PTN002260779 SGD:S000000688 SGD:S000001162 SGD:S000002504 SGD:S000005450 UniProtKB:P20585 UniProtKB:P43246 UniProtKB:P52701 ZFIN:ZDB-GENE-020905-3 ZFIN:ZDB-GENE-040426-2932	F	Seeded From UniProt	complete
enables	GO:0008094	DNA-dependent ATPase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002260779 SGD:S000001162	F	Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 PomBase:SPBC19G7.01c SGD:S000005450	P	Seeded From UniProt	complete
involved_in	GO:0006301	postreplication repair	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 UniProtKB:P43246	P	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 FB:FBgn0015546 MGI:MGI:101816 MGI:MGI:109519 MGI:MGI:1343961 PANTHER:PTN000145505 PomBase:SPBC19G7.01c PomBase:SPCC285.16c SGD:S000000688 SGD:S000001162 SGD:S000002504 SGD:S000005450 TAIR:locus:2095097 UniProtKB:P20585 UniProtKB:P43246 UniProtKB:P52701 WB:WBGene00003418 WB:WBGene00003422	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 RGD:620786 SGD:S000005450 UniProtKB:P43246	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779 SGD:S000002504 SGD:S000005450 UniProtKB:P43246 UniProtKB:P52701	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779 SGD:S000002504 SGD:S000005450	F	Seeded From UniProt	complete
enables	GO:0000406	double-strand/single-strand DNA junction binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145640 SGD:S000005450	F	Seeded From UniProt	complete
contributes_to	GO:0000400	four-way junction DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145640 UniProtKB:P43246	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032642	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR011184 InterPro:IPR016151 InterPro:IPR032642 InterPro:IPR036678	F	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR011184 InterPro:IPR016151 InterPro:IPR032642 InterPro:IPR036678	P	Seeded From UniProt	complete
enables	GO:0030983	mismatched DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR011184 InterPro:IPR016151 InterPro:IPR036678	F	Seeded From UniProt	complete
part_of	GO:0032300	mismatch repair complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032642	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mansour, AA et al. (2001) Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors. Genetics 158 77-85 PubMed GONUTS page
↑ Egel, R et al. (1984) Genes required for initiation and resolution steps of mating-type switching in fission yeast. Proc. Natl. Acad. Sci. U.S.A. 81 3481-5 PubMed GONUTS page
↑ ^3.0 ^3.1 Rudolph, C et al. (1998) Schizosaccharomyces pombe exo1 is involved in the same mismatch repair pathway as msh2 and pms1. Curr. Genet. 34 343-50 PubMed GONUTS page
↑ Rudolph, C et al. (1999) The msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization. Mol. Cell. Biol. 19 241-50 PubMed GONUTS page
↑ ^5.0 ^5.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 ^6.17 ^6.18 ^6.19 ^6.20 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11333219-1] Mansour, AA et al. (2001) Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors. Genetics 158 77-85 PubMed GONUTS page

[PMID:6587363-2] Egel, R et al. (1984) Genes required for initiation and resolution steps of mating-type switching in fission yeast. Proc. Natl. Acad. Sci. U.S.A. 81 3481-5 PubMed GONUTS page

[PMID:9871115-3] 3.0 ^3.1 Rudolph, C et al. (1998) Schizosaccharomyces pombe exo1 is involved in the same mismatch repair pathway as msh2 and pms1. Curr. Genet. 34 343-50 PubMed GONUTS page

[PMID:9858548-4] Rudolph, C et al. (1999) The msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization. Mol. Cell. Biol. 19 241-50 PubMed GONUTS page

[PMID:16823372-5] 5.0 ^5.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:21873635-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 ^6.17 ^6.18 ^6.19 ^6.20 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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SCHPO:MSH2

Contents

Annotations

Notes

References

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