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SCHPO:FEP1

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) fep1 (synonyms: gaf2)
Protein Name(s) Iron-sensing transcription factor 1

Transcription factor gaf2 Gaf-2

External Links
UniProt Q10134
EMBL AY099027
AJ457978
L29051
CU329670
PIR T38291
T43298
RefSeq NP_592936.1
ProteinModelPortal Q10134
BioGrid 278023
IntAct Q10134
MINT MINT-4697113
iPTMnet Q10134
MaxQB Q10134
PRIDE Q10134
EnsemblFungi SPAC23E2.01.1
GeneID 2541522
KEGG spo:SPAC23E2.01
EuPathDB FungiDB:SPAC23E2.01
PomBase SPAC23E2.01
InParanoid Q10134
OrthoDB EOG0927015I
PhylomeDB Q10134
PRO PR:Q10134
Proteomes UP000002485
GO GO:0000790
GO:0005634
GO:0005667
GO:0003682
GO:0003690
GO:0005506
GO:0051536
GO:0000978
GO:0001085
GO:0001214
GO:0001228
GO:0001078
GO:0008270
GO:0030154
GO:0006879
GO:0034396
Gene3D 3.30.50.10
InterPro IPR000679
IPR013088
Pfam PF00320
PRINTS PR00619
SMART SM00401
PROSITE PS00344
PS50114

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000790

nuclear chromatin

PMID:24897379[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0000978

RNA polymerase II core promoter proximal region sequence-specific DNA binding

PMID:11956219[2]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0000978

RNA polymerase II core promoter proximal region sequence-specific DNA binding

PMID:12888492[3]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0000978

RNA polymerase II core promoter proximal region sequence-specific DNA binding

PMID:15866870[4]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0000978

RNA polymerase II core promoter proximal region sequence-specific DNA binding

PMID:25733668[5]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0001078

transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding

PMID:12888492[3]

IMP: Inferred from Mutant Phenotype

-

F

Seeded From UniProt

GO:0001078

transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding

PMID:12888492[3]

IMP: Inferred from Mutant Phenotype

-

F

Seeded From UniProt

GO:0001078

transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding

PMID:12888492[3]

IMP: Inferred from Mutant Phenotype

-

F

Seeded From UniProt

GO:0001078

transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding

PMID:25733668[5]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0001078

transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding

PMID:25733668[5]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0001085

RNA polymerase II transcription factor binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000801139

F

Seeded From UniProt

GO:0001214

RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding

PMID:11956219[2]

IMP: Inferred from Mutant Phenotype

-

F

Seeded From UniProt

GO:0001214

RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding

PMID:25806539[6]

IMP: Inferred from Mutant Phenotype

-

F

Seeded From UniProt

GO:0001228

transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000801139

F

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

GO:0003682

chromatin binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000801139

F

Seeded From UniProt

GO:0003690

double-stranded DNA binding

PMID:12888492[3]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000679

F

Seeded From UniProt

GO:0005506

iron ion binding

PMID:25806539[6]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0005515

protein binding

PMID:14668334[7]

IPI: Inferred from Physical Interaction

PomBase:SPAC23E2.01

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15866870[4]

IPI: Inferred from Physical Interaction

PomBase:SPAC23E2.01

F

Seeded From UniProt

GO:0005515

protein binding

PMID:21531205[8]

IPI: Inferred from Physical Interaction

PomBase:SPBC26H8.06

F

Seeded From UniProt

GO:0005515

protein binding

PMID:24897379[1]

IPI: Inferred from Physical Interaction

PomBase:SPAC8C9.11

F

Seeded From UniProt

GO:0005515

protein binding

PMID:24897379[1]

IPI: Inferred from Physical Interaction

PomBase:SPAC8C9.11

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:15866870[4]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005634

nucleus

PMID:15866870[4]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005634

nucleus

PMID:16823372[9]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005634

nucleus

PMID:21531205[8]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005634

nucleus

PMID:24897379[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005634

nucleus

PMID:24897379[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005634

nucleus

PMID:25806539[6]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005667

transcription factor complex

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000801139

C

Seeded From UniProt

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000679
InterPro:IPR013088

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

GO:0006366

transcription from RNA polymerase II promoter

GO_REF:0000108

IEA: Inferred from Electronic Annotation

GO:0001228

P

Seeded From UniProt

GO:0006879

cellular iron ion homeostasis

PMID:11956219[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0006879

cellular iron ion homeostasis

PMID:12888492[3]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0006879

cellular iron ion homeostasis

PMID:25806539[6]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000679
InterPro:IPR013088

F

Seeded From UniProt

GO:0030154

cell differentiation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000801139

P

Seeded From UniProt

GO:0034396

negative regulation of transcription from RNA polymerase II promoter in response to iron

PMID:11956219[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0034396

negative regulation of transcription from RNA polymerase II promoter in response to iron

PMID:12888492[3]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0034396

negative regulation of transcription from RNA polymerase II promoter in response to iron

PMID:12888492[3]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0034396

negative regulation of transcription from RNA polymerase II promoter in response to iron

PMID:12888492[3]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0034396

negative regulation of transcription from RNA polymerase II promoter in response to iron

PMID:12888492[3]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0034396

negative regulation of transcription from RNA polymerase II promoter in response to iron

PMID:12888492[3]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0034396

negative regulation of transcription from RNA polymerase II promoter in response to iron

PMID:15866870[4]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0034396

negative regulation of transcription from RNA polymerase II promoter in response to iron

PMID:25733668[5]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0034396

negative regulation of transcription from RNA polymerase II promoter in response to iron

PMID:25733668[5]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000679

F

Seeded From UniProt

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO_REF:0000108

IEA: Inferred from Electronic Annotation

GO:0001228

P

Seeded From UniProt

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

GO:0051536

iron-sulfur cluster binding

PMID:27444384[10]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Jacques, JF et al. (2014) Fra2 is a co-regulator of Fep1 inhibition in response to iron starvation. PLoS ONE 9 e98959 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Pelletier, B et al. (2002) Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe. J. Biol. Chem. 277 22950-8 PubMed GONUTS page
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 Pelletier, B et al. (2003) Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system. Nucleic Acids Res. 31 4332-44 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Pelletier, B et al. (2005) Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe. J. Biol. Chem. 280 25146-61 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 Mourer, T et al. (2015) Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe. J. Biol. Chem. 290 10176-90 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Encinar del Dedo, J et al. (2015) A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast. PLoS Genet. 11 e1005106 PubMed GONUTS page
  7. Znaidi, S et al. (2004) The Schizosaccharomyces pombe corepressor Tup11 interacts with the iron-responsive transcription factor Fep1. J. Biol. Chem. 279 9462-74 PubMed GONUTS page
  8. 8.0 8.1 Kim, KD et al. (2011) Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast. Biochem. Biophys. Res. Commun. 408 609-14 PubMed GONUTS page
  9. Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  10. Kim, HJ et al. (2016) The iron uptake repressor Fep1 in the fission yeast binds Fe-S cluster through conserved cysteines. Biochem. Biophys. Res. Commun. 478 187-92 PubMed GONUTS page