SCHPO:FEP1

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	fep1 (synonyms: gaf2)
Protein Name(s)	Iron-sensing transcription factor 1 Transcription factor gaf2 Gaf-2
External Links
UniProt	Q10134
EMBL	AY099027 AJ457978 L29051 CU329670
PIR	T38291 T43298
RefSeq	NP_592936.1
ProteinModelPortal	Q10134
SMR	Q10134
BioGrid	278023
IntAct	Q10134
STRING	4896.SPAC23E2.01.1
iPTMnet	Q10134
MaxQB	Q10134
PaxDb	Q10134
PRIDE	Q10134
EnsemblFungi	SPAC23E2.01.1
GeneID	2541522
KEGG	spo:SPAC23E2.01
EuPathDB	FungiDB:SPAC23E2.01
PomBase	SPAC23E2.01
InParanoid	Q10134
OMA	NPICNAC
PhylomeDB	Q10134
Reactome	R-SPO-9018519
PRO	PR:Q10134
Proteomes	UP000002485
GO	GO:0000790 GO:0005634 GO:0000981 GO:0001227 GO:0003690 GO:0005506 GO:0051536 GO:0000978 GO:0008270 GO:0006879 GO:1901967 GO:0097739 GO:0034396
CDD	cd00202
Gene3D	3.30.50.10
InterPro	IPR039355 IPR000679 IPR013088
PANTHER	PTHR10071
Pfam	PF00320
PRINTS	PR00619
SMART	SM00401
PROSITE	PS00344 PS50114

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0097739	negative regulation of ferrichrome biosynthetic process in response to iron	PMID:20435771^[1]	ECO:0000305	curator inference used in manual assertion	GO:0001078	P	has_regulation_target:(PomBase:SPAC23G3.03) part_of:(GO:0097739)	Seeded From UniProt	complete
involved_in	GO:1901967	negative regulation of cellular response to iron ion starvation	PMID:25733668^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097739	negative regulation of ferrichrome biosynthetic process in response to iron	PMID:20435771^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051536	iron-sulfur cluster binding	PMID:27444384^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034396	negative regulation of transcription from RNA polymerase II promoter in response to iron	PMID:25733668^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPAC1F8.02c)	Seeded From UniProt	complete
involved_in	GO:0034396	negative regulation of transcription from RNA polymerase II promoter in response to iron	PMID:25733668^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPAC1F7.08)	Seeded From UniProt	complete
involved_in	GO:0034396	negative regulation of transcription from RNA polymerase II promoter in response to iron	PMID:15866870^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034396	negative regulation of transcription from RNA polymerase II promoter in response to iron	PMID:12888492^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPCC61.01c)	Seeded From UniProt	complete
involved_in	GO:0034396	negative regulation of transcription from RNA polymerase II promoter in response to iron	PMID:12888492^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPBC4F6.09)	Seeded From UniProt	complete
involved_in	GO:0034396	negative regulation of transcription from RNA polymerase II promoter in response to iron	PMID:12888492^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPAC1F8.03c)	Seeded From UniProt	complete
involved_in	GO:0034396	negative regulation of transcription from RNA polymerase II promoter in response to iron	PMID:12888492^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPAC1F7.08)	Seeded From UniProt	complete
involved_in	GO:0034396	negative regulation of transcription from RNA polymerase II promoter in response to iron	PMID:12888492^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPAC1F7.07c)	Seeded From UniProt	complete
involved_in	GO:0034396	negative regulation of transcription from RNA polymerase II promoter in response to iron	PMID:11956219^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPAC1F7.08)	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	PMID:25806539^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	PMID:12888492^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	PMID:11956219^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16823372^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25806539^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24897379^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071281)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24897379^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0010106)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21531205^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15866870^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071281)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15866870^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0010106)	Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	PMID:25806539^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:12888492^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:25806539^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:20435771^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(PomBase:SPAC23G3.03) part_of:(GO:0097739)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:20435771^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(PomBase:SPAC23G3.02c) part_of:(GO:0097739)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:12888492^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(PomBase:SPCC61.01c) part_of:(GO:0071281)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:12888492^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(PomBase:SPBC4F6.09) part_of:(GO:0071281)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:12888492^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(PomBase:SPAC1F8.03c) part_of:(GO:0071281)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:11956219^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(PomBase:SPAC1F7.08) part_of:(GO:0071281)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:25733668^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(PomBase:SPAC1F8.02c) part_of:(GO:0071281)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:25733668^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(PomBase:SPAC1F7.08) part_of:(GO:0071281)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:25733668^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001851) part_of:(GO:0071281)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:15866870^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001851)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:12888492^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001851)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:11956219^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001851)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:24897379^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(PomBase:SPAC1F7.08) exists_during:(GO:0071281)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003117 FB:FBgn0032223 FB:FBgn0038391 MGI:MGI:107516 MGI:MGI:109497 MGI:MGI:95661 MGI:MGI:95662 MGI:MGI:95663 MGI:MGI:95664 PANTHER:PTN001600628 PomBase:SPAC23E2.01 PomBase:SPCC1902.01 RGD:2663 RGD:2664 RGD:2665 RGD:2666 RGD:621250 SGD:S000000842 SGD:S000001742 SGD:S000001873 SGD:S000003646 UniProtKB:E1C9C6 UniProtKB:I3LUZ9 UniProtKB:P15976 UniProtKB:P17429 UniProtKB:P23769 UniProtKB:P23771 UniProtKB:P43691 UniProtKB:P43692 UniProtKB:P43694 UniProtKB:Q92908 UniProtKB:Q9BWX5 WB:WBGene00001186 WB:WBGene00001249 WB:WBGene00001250 WB:WBGene00001251 WB:WBGene00001252 WB:WBGene00001253 WB:WBGene00001310 WB:WBGene00001311 WB:WBGene00015981 ZFIN:ZDB-GENE-980526-340	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003117 MGI:MGI:95661 MGI:MGI:95664 PANTHER:PTN001600628 RGD:2665 SGD:S000001742 SGD:S000003646 UniProtKB:P23769 UniProtKB:P43694 UniProtKB:Q92908 WB:WBGene00001249 WB:WBGene00001310	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107516 MGI:MGI:95661 MGI:MGI:95662 MGI:MGI:95663 MGI:MGI:95664 PANTHER:PTN001600628 PomBase:SPAC23E2.01 PomBase:SPCC1902.01 SGD:S000000842 UniProtKB:P15976 UniProtKB:P23771	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039355	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679 InterPro:IPR013088 InterPro:IPR039355	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Mercier, A & Labbé, S (2010) Iron-dependent remodeling of fungal metabolic pathways associated with ferrichrome biosynthesis. Appl. Environ. Microbiol. 76 3806-17 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Mourer, T et al. (2015) Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe. J. Biol. Chem. 290 10176-90 PubMed GONUTS page
↑ Kim, HJ et al. (2016) The iron uptake repressor Fep1 in the fission yeast binds Fe-S cluster through conserved cysteines. Biochem. Biophys. Res. Commun. 478 187-92 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Pelletier, B et al. (2005) Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe. J. Biol. Chem. 280 25146-61 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Pelletier, B et al. (2003) Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system. Nucleic Acids Res. 31 4332-44 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Pelletier, B et al. (2002) Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe. J. Biol. Chem. 277 22950-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Encinar del Dedo, J et al. (2015) A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast. PLoS Genet. 11 e1005106 PubMed GONUTS page
↑ Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Jacques, JF et al. (2014) Fra2 is a co-regulator of Fep1 inhibition in response to iron starvation. PLoS ONE 9 e98959 PubMed GONUTS page
↑ Kim, KD et al. (2011) Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast. Biochem. Biophys. Res. Commun. 408 609-14 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20435771-1] 1.0 ^1.1 ^1.2 ^1.3 Mercier, A & Labbé, S (2010) Iron-dependent remodeling of fungal metabolic pathways associated with ferrichrome biosynthesis. Appl. Environ. Microbiol. 76 3806-17 PubMed GONUTS page

[PMID:25733668-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Mourer, T et al. (2015) Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe. J. Biol. Chem. 290 10176-90 PubMed GONUTS page

[PMID:27444384-3] Kim, HJ et al. (2016) The iron uptake repressor Fep1 in the fission yeast binds Fe-S cluster through conserved cysteines. Biochem. Biophys. Res. Commun. 478 187-92 PubMed GONUTS page

[PMID:15866870-4] 4.0 ^4.1 ^4.2 ^4.3 Pelletier, B et al. (2005) Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe. J. Biol. Chem. 280 25146-61 PubMed GONUTS page

[PMID:12888492-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Pelletier, B et al. (2003) Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system. Nucleic Acids Res. 31 4332-44 PubMed GONUTS page

[PMID:11956219-6] 6.0 ^6.1 ^6.2 ^6.3 Pelletier, B et al. (2002) Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe. J. Biol. Chem. 277 22950-8 PubMed GONUTS page

[PMID:25806539-7] 7.0 ^7.1 ^7.2 ^7.3 Encinar del Dedo, J et al. (2015) A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast. PLoS Genet. 11 e1005106 PubMed GONUTS page

[PMID:16823372-8] Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:24897379-9] 9.0 ^9.1 ^9.2 Jacques, JF et al. (2014) Fra2 is a co-regulator of Fep1 inhibition in response to iron starvation. PLoS ONE 9 e98959 PubMed GONUTS page

[PMID:21531205-10] Kim, KD et al. (2011) Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast. Biochem. Biophys. Res. Commun. 408 609-14 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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SCHPO:FEP1

Contents

Annotations

Notes

References

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