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SCHPO:EXO1

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) exo1
Protein Name(s) Exodeoxyribonuclease 1

Exodeoxyribonuclease I EXO I Exonuclease I

External Links
UniProt P53695
EMBL L35174
CU329671
PIR T43288
RefSeq NP_596050.1
ProteinModelPortal P53695
STRING P53695
EnsemblFungi SPBC29A10.05.1
GeneID 2540348
GenomeReviews CU329671_GR
KEGG spo:SPBC29A10.05
PomBase SPBC29A10.05
eggNOG COG0258
KO K10746
OrthoDB EOG44QX8J
BioCyc SPOM-XXX-01:SPOM-XXX-01-004097-MONOMER
NextBio 20801476
ArrayExpress P53695
GO GO:0005634
GO:0005819
GO:0008409
GO:0017108
GO:0003690
GO:0046872
GO:0043570
GO:0000706
GO:0006298
GO:0006312
GO:0000723
InterPro IPR020045
IPR008918
IPR006086
IPR019974
IPR006085
IPR006084
PANTHER PTHR11081
Pfam PF00867
PF00752
PRINTS PR00853
SMART SM00279
SM00484
SM00485
SUPFAM SSF47807
PROSITE PS00841
PS00842

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000706

meiotic DNA double-strand break processing

PMID:15474417[1]

TAS: Traceable Author Statement

-

P

Seeded From UniProt

GO:0000723

telomere maintenance

PMID:15474417[1]

TAS: Traceable Author Statement

-

P

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008918
InterPro:IPR020045

F

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

GO:0003690

double-stranded DNA binding

PMID:1737756[2]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0003824

catalytic activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008918
InterPro:IPR020045

F

Seeded From UniProt

GO:0004518

nuclease activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006084
InterPro:IPR006085
InterPro:IPR006086

F

Seeded From UniProt

GO:0004518

nuclease activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0267

F

Seeded From UniProt

GO:0004518

nuclease activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0540

F

Seeded From UniProt

GO:0004527

exonuclease activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0269

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000005559

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:16823372[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005819

spindle

PMID:16823372[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0006281

DNA repair

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006084
InterPro:IPR006085
InterPro:IPR006086

P

Seeded From UniProt

GO:0006281

DNA repair

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0234

P

Seeded From UniProt

GO:0006298

mismatch repair

PMID:7855597[4]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0006298

mismatch repair

PMID:9871115[5]

IGI: Inferred from Genetic Interaction

PomBase:SPAC19G12.02c

P

Seeded From UniProt

GO:0006298

mismatch repair

PMID:9871115[5]

IGI: Inferred from Genetic Interaction

PomBase:SPBC19G7.01c

P

Seeded From UniProt

GO:0006312

mitotic recombination

PMID:15474417[1]

TAS: Traceable Author Statement

-

P

Seeded From UniProt

GO:0006974

response to DNA damage stimulus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0227

P

Seeded From UniProt

GO:0008409

5'-3' exonuclease activity

PMID:7855597[4]

IMP: Inferred from Mutant Phenotype

-

F

Seeded From UniProt

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

GO:0016788

hydrolase activity, acting on ester bonds

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR019974

F

Seeded From UniProt

GO:0017108

5'-flap endonuclease activity

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000005559

F

Seeded From UniProt

GO:0043570

maintenance of DNA repeat elements

PMID:11333219[6]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Tran, PT et al. (2004) EXO1-A multi-tasking eukaryotic nuclease. DNA Repair (Amst.) 3 1549-59 PubMed GONUTS page
  2. Szankasi, P & Smith, GR (1992) A DNA exonuclease induced during meiosis of Schizosaccharomyces pombe. J. Biol. Chem. 267 3014-23 PubMed GONUTS page
  3. 3.0 3.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  4. 4.0 4.1 Szankasi, P & Smith, GR (1995) A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction. Science 267 1166-9 PubMed GONUTS page
  5. 5.0 5.1 Rudolph, C et al. (1998) Schizosaccharomyces pombe exo1 is involved in the same mismatch repair pathway as msh2 and pms1. Curr. Genet. 34 343-50 PubMed GONUTS page
  6. Mansour, AA et al. (2001) Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors. Genetics 158 77-85 PubMed GONUTS page