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SCHPO:EXO1

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) exo1
Protein Name(s) Exodeoxyribonuclease 1

Exodeoxyribonuclease I EXO I Exonuclease I

External Links
UniProt P53695
EMBL L35174
CU329671
PIR T43288
RefSeq NP_596050.1
ProteinModelPortal P53695
SMR P53695
BioGrid 276877
STRING 4896.SPBC29A10.05.1
iPTMnet P53695
MaxQB P53695
PaxDb P53695
PRIDE P53695
EnsemblFungi SPBC29A10.05.1
GeneID 2540348
KEGG spo:SPBC29A10.05
EuPathDB FungiDB:SPBC29A10.05
PomBase SPBC29A10.05
InParanoid P53695
KO K10746
OMA VFTCAHE
PhylomeDB P53695
Reactome R-SPO-5358565
PRO PR:P53695
Proteomes UP000002485
GO GO:0072686
GO:0005634
GO:0035861
GO:0035312
GO:0017108
GO:0051908
GO:0003690
GO:0048256
GO:0046872
GO:0000729
GO:0006310
GO:0110025
GO:0043570
GO:0000706
GO:0000710
GO:0006298
GO:1903211
GO:0000723
CDD cd09908
InterPro IPR036279
IPR032641
IPR037315
IPR008918
IPR029060
IPR006086
IPR006084
IPR019974
IPR006085
PANTHER PTHR11081
PTHR11081:SF8
Pfam PF00867
PF00752
PRINTS PR00853
SMART SM00279
SM00484
SM00485
SUPFAM SSF47807
SSF88723
PROSITE PS00841
PS00842

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1903211

mitotic recombination involved in replication fork processing

PMID:29215009[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0110025

DNA strand resection involved in replication fork processing

PMID:29215009[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0072686

mitotic spindle

PMID:16823372[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0051908

double-stranded DNA 5'-3' exodeoxyribonuclease activity

PMID:7855597[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051908

double-stranded DNA 5'-3' exodeoxyribonuclease activity

PMID:1737756[4]

ECO:0000314

direct assay evidence used in manual assertion

F

happens_during:(GO:0051331)

Seeded From UniProt

complete

involved_in

GO:0043570

maintenance of DNA repeat elements

PMID:11333219[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035861

site of double-strand break

PMID:23211746[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:9871115[7]

ECO:0000316

genetic interaction evidence used in manual assertion

PomBase:SPBC19G7.01c

P

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:9871115[7]

ECO:0000316

genetic interaction evidence used in manual assertion

PomBase:SPAC19G12.02c

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16823372[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

PMID:1737756[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000729

DNA double-strand break processing

PMID:12861005[8]

ECO:0000316

genetic interaction evidence used in manual assertion

PomBase:SPAC1556.01c

P

Seeded From UniProt

complete

involved_in

GO:0000729

DNA double-strand break processing

PMID:21931565[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000710

meiotic mismatch repair

PMID:7855597[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0048256

flap endonuclease activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0263831
MGI:MGI:102779
PANTHER:PTN000118612
PomBase:SPAC3G6.06c
SGD:S000001596
SGD:S000005559
UniProtKB:P39748
UniProtKB:Q17RS7
UniProtKB:Q7K734
UniProtKB:Q9UQ84
WB:WBGene00000794

F

Seeded From UniProt

complete

enables

GO:0035312

5'-3' exodeoxyribonuclease activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000118621
PomBase:SPBC29A10.05
SGD:S000002671
UniProtKB:Q9UQ84

F

Seeded From UniProt

complete

enables

GO:0017108

5'-flap endonuclease activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0263831
PANTHER:PTN000118612
PomBase:SPAC3G6.06c
SGD:S000001596
SGD:S000005559
UniProtKB:P39748
UniProtKB:Q17RS7

F

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000118621
UniProtKB:Q9UQ84

P

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000118621
PomBase:SPBC29A10.05
SGD:S000005559
UniProtKB:Q9UQ84

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000118621
UniProtKB:Q9UQ84

C

Seeded From UniProt

complete

involved_in

GO:0000729

DNA double-strand break processing

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000871648
PomBase:SPBC29A10.05
SGD:S000005559

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004518

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0035312

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0051908

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0051908

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0035312

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004518

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004527

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004518

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008918
InterPro:IPR037315

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008918

F

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006084
InterPro:IPR006085
InterPro:IPR006086

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006084
InterPro:IPR006085
InterPro:IPR032641

P

Seeded From UniProt

complete

enables

GO:0016788

hydrolase activity, acting on ester bonds

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019974

F

Seeded From UniProt

complete

enables

GO:0035312

5'-3' exodeoxyribonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032641
InterPro:IPR037315

F

Seeded From UniProt

complete

involved_in

GO:0000723

telomere maintenance

PMID:15474417[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000706

meiotic DNA double-strand break processing

PMID:15474417[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540
UniProtKB-KW:KW-0267

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0004527

exonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0269

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Teixeira-Silva, A et al. (2017) The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks. Nat Commun 8 1982 PubMed GONUTS page
  2. 2.0 2.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  3. 3.0 3.1 Szankasi, P & Smith, GR (1995) A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction. Science 267 1166-9 PubMed GONUTS page
  4. 4.0 4.1 Szankasi, P & Smith, GR (1992) A DNA exonuclease induced during meiosis of Schizosaccharomyces pombe. J. Biol. Chem. 267 3014-23 PubMed GONUTS page
  5. Mansour, AA et al. (2001) Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors. Genetics 158 77-85 PubMed GONUTS page
  6. Kuntz, K & O'Connell, MJ (2013) Initiation of DNA damage responses through XPG-related nucleases. EMBO J. 32 290-302 PubMed GONUTS page
  7. 7.0 7.1 Rudolph, C et al. (1998) Schizosaccharomyces pombe exo1 is involved in the same mismatch repair pathway as msh2 and pms1. Curr. Genet. 34 343-50 PubMed GONUTS page
  8. Tomita, K et al. (2003) Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres. Mol. Cell. Biol. 23 5186-97 PubMed GONUTS page
  9. Langerak, P et al. (2011) Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks. PLoS Genet. 7 e1002271 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 10.5 10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  11. 11.0 11.1 Tran, PT et al. (2004) EXO1-A multi-tasking eukaryotic nuclease. DNA Repair (Amst.) 3 1549-59 PubMed GONUTS page