SCHPO:EXO1

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	exo1
Protein Name(s)	Exodeoxyribonuclease 1 Exodeoxyribonuclease I EXO I Exonuclease I
External Links
UniProt	P53695
EMBL	L35174 CU329671
PIR	T43288
RefSeq	NP_596050.1
ProteinModelPortal	P53695
SMR	P53695
BioGrid	276877
STRING	4896.SPBC29A10.05.1
iPTMnet	P53695
MaxQB	P53695
PaxDb	P53695
PRIDE	P53695
EnsemblFungi	SPBC29A10.05.1
GeneID	2540348
KEGG	spo:SPBC29A10.05
EuPathDB	FungiDB:SPBC29A10.05
PomBase	SPBC29A10.05
InParanoid	P53695
KO	K10746
OMA	VFTCAHE
PhylomeDB	P53695
Reactome	R-SPO-5358565
PRO	PR:P53695
Proteomes	UP000002485
GO	GO:0072686 GO:0005634 GO:0035861 GO:0035312 GO:0017108 GO:0051908 GO:0003690 GO:0048256 GO:0046872 GO:0000729 GO:0006310 GO:0110025 GO:0043570 GO:0000706 GO:0000710 GO:0006298 GO:1903211 GO:0000723
CDD	cd09908
InterPro	IPR036279 IPR032641 IPR037315 IPR008918 IPR029060 IPR006086 IPR006084 IPR019974 IPR006085
PANTHER	PTHR11081 PTHR11081:SF8
Pfam	PF00867 PF00752
PRINTS	PR00853
SMART	SM00279 SM00484 SM00485
SUPFAM	SSF47807 SSF88723
PROSITE	PS00841 PS00842

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1903211	mitotic recombination involved in replication fork processing	PMID:29215009^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0110025	DNA strand resection involved in replication fork processing	PMID:29215009^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	PMID:16823372^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0051908	double-stranded DNA 5'-3' exodeoxyribonuclease activity	PMID:7855597^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051908	double-stranded DNA 5'-3' exodeoxyribonuclease activity	PMID:1737756^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	happens_during:(GO:0051331)	Seeded From UniProt	complete
involved_in	GO:0043570	maintenance of DNA repeat elements	PMID:11333219^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:23211746^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:9871115^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC19G7.01c	P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:9871115^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPAC19G12.02c	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16823372^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:1737756^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	PMID:12861005^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPAC1556.01c	P		Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	PMID:21931565^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000710	meiotic mismatch repair	PMID:7855597^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048256	flap endonuclease activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263831 MGI:MGI:102779 PANTHER:PTN000118612 PomBase:SPAC3G6.06c SGD:S000001596 SGD:S000005559 UniProtKB:P39748 UniProtKB:Q17RS7 UniProtKB:Q7K734 UniProtKB:Q9UQ84 WB:WBGene00000794	F		Seeded From UniProt	complete
enables	GO:0035312	5'-3' exodeoxyribonuclease activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000118621 PomBase:SPBC29A10.05 SGD:S000002671 UniProtKB:Q9UQ84	F		Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263831 PANTHER:PTN000118612 PomBase:SPAC3G6.06c SGD:S000001596 SGD:S000005559 UniProtKB:P39748 UniProtKB:Q17RS7	F		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000118621 UniProtKB:Q9UQ84	P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000118621 PomBase:SPBC29A10.05 SGD:S000005559 UniProtKB:Q9UQ84	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000118621 UniProtKB:Q9UQ84	C		Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000871648 PomBase:SPBC29A10.05 SGD:S000005559	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0035312	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0051908	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0051908	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035312	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004527	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008918 InterPro:IPR037315	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008918	F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006084 InterPro:IPR006085 InterPro:IPR006086	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006084 InterPro:IPR006085 InterPro:IPR032641	P		Seeded From UniProt	complete
enables	GO:0016788	hydrolase activity, acting on ester bonds	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019974	F		Seeded From UniProt	complete
enables	GO:0035312	5'-3' exodeoxyribonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032641 InterPro:IPR037315	F		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:15474417^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000706	meiotic DNA double-strand break processing	PMID:15474417^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540 UniProtKB-KW:KW-0267	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004527	exonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0269	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Teixeira-Silva, A et al. (2017) The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks. Nat Commun 8 1982 PubMed GONUTS page
↑ ^2.0 ^2.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Szankasi, P & Smith, GR (1995) A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction. Science 267 1166-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Szankasi, P & Smith, GR (1992) A DNA exonuclease induced during meiosis of Schizosaccharomyces pombe. J. Biol. Chem. 267 3014-23 PubMed GONUTS page
↑ Mansour, AA et al. (2001) Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors. Genetics 158 77-85 PubMed GONUTS page
↑ Kuntz, K & O'Connell, MJ (2013) Initiation of DNA damage responses through XPG-related nucleases. EMBO J. 32 290-302 PubMed GONUTS page
↑ ^7.0 ^7.1 Rudolph, C et al. (1998) Schizosaccharomyces pombe exo1 is involved in the same mismatch repair pathway as msh2 and pms1. Curr. Genet. 34 343-50 PubMed GONUTS page
↑ Tomita, K et al. (2003) Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres. Mol. Cell. Biol. 23 5186-97 PubMed GONUTS page
↑ Langerak, P et al. (2011) Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks. PLoS Genet. 7 e1002271 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 Tran, PT et al. (2004) EXO1-A multi-tasking eukaryotic nuclease. DNA Repair (Amst.) 3 1549-59 PubMed GONUTS page

[PMID:29215009-1] 1.0 ^1.1 Teixeira-Silva, A et al. (2017) The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks. Nat Commun 8 1982 PubMed GONUTS page

[PMID:16823372-2] 2.0 ^2.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:7855597-3] 3.0 ^3.1 Szankasi, P & Smith, GR (1995) A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction. Science 267 1166-9 PubMed GONUTS page

[PMID:1737756-4] 4.0 ^4.1 Szankasi, P & Smith, GR (1992) A DNA exonuclease induced during meiosis of Schizosaccharomyces pombe. J. Biol. Chem. 267 3014-23 PubMed GONUTS page

[PMID:11333219-5] Mansour, AA et al. (2001) Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors. Genetics 158 77-85 PubMed GONUTS page

[PMID:23211746-6] Kuntz, K & O'Connell, MJ (2013) Initiation of DNA damage responses through XPG-related nucleases. EMBO J. 32 290-302 PubMed GONUTS page

[PMID:9871115-7] 7.0 ^7.1 Rudolph, C et al. (1998) Schizosaccharomyces pombe exo1 is involved in the same mismatch repair pathway as msh2 and pms1. Curr. Genet. 34 343-50 PubMed GONUTS page

[PMID:12861005-8] Tomita, K et al. (2003) Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres. Mol. Cell. Biol. 23 5186-97 PubMed GONUTS page

[PMID:21931565-9] Langerak, P et al. (2011) Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks. PLoS Genet. 7 e1002271 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15474417-11] 11.0 ^11.1 Tran, PT et al. (2004) EXO1-A multi-tasking eukaryotic nuclease. DNA Repair (Amst.) 3 1549-59 PubMed GONUTS page

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SCHPO:EXO1

Contents

Annotations

Notes

References

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