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SCHPO:CUT7

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) cut7
Protein Name(s) Kinesin-like protein cut7

Cell untimely torn protein 7

External Links
UniProt P24339
EMBL X57513
CU329670
PIR S14032
T38378
RefSeq NP_594527.1
ProteinModelPortal P24339
BioGrid 279182
DIP DIP-61701N
MINT MINT-4687825
MaxQB P24339
EnsemblFungi SPAC25G10.07c.1
GeneID 2542732
KEGG spo:SPAC25G10.07c
EuPathDB FungiDB:SPAC25G10.07c
PomBase SPAC25G10.07c
InParanoid P24339
KO K10398
OMA HTHEESQ
OrthoDB EOG7RRFGF
PhylomeDB P24339
Reactome [www.reactome.org/content/detail/R-SPO-983189 R-SPO-983189]
PRO PR:P24339
Proteomes UP000002485
GO GO:0000777
GO:0005737
GO:0072687
GO:0005875
GO:0015630
GO:1990023
GO:0044732
GO:0005634
GO:0005876
GO:0005524
GO:0008574
GO:0051301
GO:0099606
GO:0090307
GO:0051256
Gene3D 3.40.850.10
InterPro IPR027640
IPR019821
IPR001752
IPR027417
PANTHER PTHR24115
Pfam PF00225
PRINTS PR00380
SMART SM00129
SUPFAM SSF52540
PROSITE PS00411
PS50067

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

GO:0000777

condensed chromosome kinetochore

PMID:26258632[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0003777

microtubule motor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001752
InterPro:IPR019821

F

Seeded From UniProt

GO:0005515

protein binding

PMID:26258632[1]

IPI: Inferred from Physical Interaction

PomBase:SPBC3D6.04c

F

Seeded From UniProt

GO:0005515

protein binding

PMID:9490630[2]

IPI: Inferred from Physical Interaction

PomBase:SPBC11B10.09

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001752
InterPro:IPR019821

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

GO:0005634

nucleus

PMID:16823372[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

GO:0005816

spindle pole body

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0252

C

Seeded From UniProt

GO:0005856

cytoskeleton

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0206

C

Seeded From UniProt

GO:0005871

kinesin complex

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000648413

C

Seeded From UniProt

GO:0005874

microtubule

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0493

C

Seeded From UniProt

GO:0005876

spindle microtubule

PMID:1538784[4]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0007018

microtubule-based movement

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001752
InterPro:IPR019821

P

Seeded From UniProt

GO:0007018

microtubule-based movement

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000648413

P

Seeded From UniProt

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

GO:0007067

mitotic nuclear division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0498

P

Seeded From UniProt

GO:0008017

microtubule binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001752

F

Seeded From UniProt

GO:0008574

ATP-dependent microtubule motor activity, plus-end-directed

PMID:19838064[5]

TAS: Traceable Author Statement

-

F

Seeded From UniProt

GO:0010970

transport along microtubule

GO_REF:0000050

ISM: Inferred from Sequence Model

Pfam:PF00225

P

Seeded From UniProt

GO:0015630

microtubule cytoskeleton

PMID:16823372[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0044732

mitotic spindle pole body

PMID:1538784[4]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0044732

mitotic spindle pole body

PMID:16823372[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0051256

mitotic spindle midzone assembly

PMID:18418055[6]

IGI: Inferred from Genetic Interaction

PomBase:SPBC32F12.04

P

Seeded From UniProt

GO:0051256

mitotic spindle midzone assembly

PMID:2145514[7]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0051301

cell division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

Seeded From UniProt

GO:0072687

meiotic spindle

PMID:1538784[4]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0090307

mitotic spindle assembly

PMID:8898367[8]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0099606

microtubule plus-end directed mitotic chromosome migration

PMID:26258632[1]

IGI: Inferred from Genetic Interaction

PomBase:SPBC3D6.04c

P

Seeded From UniProt

GO:1990023

mitotic spindle midzone

PMID:1538784[4]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0008574

ATP-dependent microtubule motor activity, plus-end-directed

PMID:27834216[9]

IDA: Inferred from Direct Assay

F

Figure 2. Part C details how ATP added to the Cut7 motor after flush with a buffer reverses a minus-end directed activity into a plus-end directed step. The organism is S. pombe.

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Akera, T et al. (2015) Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore. Nat. Cell Biol. 17 1124-33 PubMed GONUTS page
  2. Drummond, DR & Hagan, IM (1998) Mutations in the bimC box of Cut7 indicate divergence of regulation within the bimC family of kinesin related proteins. J. Cell. Sci. 111 ( Pt 7) 853-65 PubMed GONUTS page
  3. 3.0 3.1 3.2 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Hagan, I & Yanagida, M (1992) Kinesin-related cut7 protein associates with mitotic and meiotic spindles in fission yeast. Nature 356 74-6 PubMed GONUTS page
  5. Simeonov, DR et al. (2009) Distinct Kinesin-14 mitotic mechanisms in spindle bipolarity. Cell Cycle 8 3571-83 PubMed GONUTS page
  6. Rodriguez, AS et al. (2008) Protein complexes at the microtubule organizing center regulate bipolar spindle assembly. Cell Cycle 7 1246-53 PubMed GONUTS page
  7. Hagan, I & Yanagida, M (1990) Novel potential mitotic motor protein encoded by the fission yeast cut7+ gene. Nature 347 563-6 PubMed GONUTS page
  8. Pidoux, AL et al. (1996) Fission yeast pkl1 is a kinesin-related protein involved in mitotic spindle function. Mol. Biol. Cell 7 1639-55 PubMed GONUTS page
  9. Britto, M et al. (2016) Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism. Proc. Natl. Acad. Sci. U.S.A. 113 E7483-E7489 PubMed GONUTS page