SCHPO:CUT7

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	cut7
Protein Name(s)	Kinesin-like protein cut7 Cell untimely torn protein 7
External Links
UniProt	P24339
EMBL	X57513 CU329670
PIR	S14032 T38378
RefSeq	NP_594527.1
PDB	5M5I 5M5L 5M5M 5M5N 5M5O 5MLV
PDBsum	5M5I 5M5L 5M5M 5M5N 5M5O 5MLV
ProteinModelPortal	P24339
SMR	P24339
BioGrid	279182
DIP	DIP-61701N
IntAct	P24339
STRING	4896.SPAC25G10.07c.1
iPTMnet	P24339
MaxQB	P24339
PaxDb	P24339
PRIDE	P24339
EnsemblFungi	SPAC25G10.07c.1
GeneID	2542732
KEGG	spo:SPAC25G10.07c
EuPathDB	FungiDB:SPAC25G10.07c
PomBase	SPAC25G10.07c
InParanoid	P24339
KO	K10398
OMA	SVKCSFI
PhylomeDB	P24339
Reactome	R-SPO-983189
PRO	PR:P24339
Proteomes	UP000002485
GO	GO:0000778 GO:0005737 GO:0005871 GO:0072687 GO:0005874 GO:0005875 GO:0015630 GO:1990023 GO:0044732 GO:0005634 GO:0005876 GO:0005524 GO:0008574 GO:0016887 GO:0008017 GO:0003777 GO:0051301 GO:0099606 GO:0007018 GO:0090307 GO:0051256 GO:0000073
Gene3D	3.40.850.10
InterPro	IPR027640 IPR019821 IPR001752 IPR036961 IPR027417
PANTHER	PTHR24115
Pfam	PF00225
PRINTS	PR00380
SMART	SM00129
SUPFAM	SSF52540
PROSITE	PS00411 PS50067

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	PMID:27834216^[1]	ECO:0000314			F		Figure 2. Part C details how ATP added to the Cut7 motor after flush with a buffer reverses a minus-end directed activity into a plus-end directed step. The organism is S. pombe.	complete CACAO 12267
enables	GO:1990939	ATP-dependent microtubule motor activity	PMID:30659798^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1990023	mitotic spindle midzone	PMID:1538784^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000092)	Seeded From UniProt	complete
involved_in	GO:0099606	microtubule plus-end directed mitotic chromosome migration	PMID:26258632^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC3D6.04c	P		Seeded From UniProt	complete
part_of	GO:0072687	meiotic spindle	PMID:1538784^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051256	mitotic spindle midzone assembly	PMID:18418055^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC32F12.04	P		Seeded From UniProt	complete
involved_in	GO:0051256	mitotic spindle midzone assembly	PMID:2145514^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0044732	mitotic spindle pole body	PMID:16823372^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044732	mitotic spindle pole body	PMID:1538784^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	PMID:16823372^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:30659798^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	GO_REF:0000111	ECO:0000305	curator inference used in manual assertion	GO:0003777	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16823372^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000778	condensed nuclear chromosome kinetochore	PMID:26258632^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000089)	Seeded From UniProt	complete
involved_in	GO:0000073	mitotic spindle pole body separation	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000000787	P		Seeded From UniProt	complete
involved_in	GO:0090307	mitotic spindle assembly	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000649235 SGD:S000000159 SGD:S000000787 UniProtKB:P52732	P		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108426 MGI:MGI:1098226 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPBC1604.20c PomBase:SPBC1685.15c PomBase:SPBC2F12.13 RGD:621520 TAIR:locus:2148543 TAIR:locus:2157533 UniProtKB:C8V3Q8 UniProtKB:Q96Q89 dictyBase:DDB_G0280967	F		Seeded From UniProt	complete
enables	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004378 PANTHER:PTN000649234 SGD:S000000787	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000352 FB:FBgn0001308 FB:FBgn0004378 FB:FBgn0011606 MGI:MGI:107689 MGI:MGI:108391 MGI:MGI:109564 MGI:MGI:1098226 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPAC3A11.14c PomBase:SPAC664.10 PomBase:SPBC1604.20c PomBase:SPBC1685.15c PomBase:SPBC2F12.13 RGD:1304996 RGD:1306815 RGD:621538 RGD:621559 SGD:S000006345 TAIR:locus:2129630 TAIR:locus:2136437 TAIR:locus:2148543 TAIR:locus:2157533 UniProtKB:O00139 UniProtKB:P17120 UniProtKB:P33176 UniProtKB:Q02224 UniProtKB:Q02241 UniProtKB:Q8NI77 UniProtKB:Q96Q89 WB:WBGene00006831 WB:WBGene00006974 dictyBase:DDB_G0276369	F		Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0004378 FB:FBgn0004381 MGI:MGI:108426 MGI:MGI:2447072 PANTHER:PTN000648413 WB:WBGene00002222 WB:WBGene00002225 WB:WBGene00002230 WB:WBGene00006831 WB:WBGene00006974 dictyBase:DDB_G0281555	P		Seeded From UniProt	complete
part_of	GO:0005876	spindle microtubule	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000649235 SGD:S000000159 SGD:S000000787 UniProtKB:P52732	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004378 PANTHER:PTN000648413 RGD:1303035 RGD:1304996 RGD:621538 TAIR:locus:2089358 UniProtKB:O00139 UniProtKB:P52732 UniProtKB:Q02224 UniProtKB:Q15058 UniProtKB:Q9HAQ2 WB:WBGene00002228 WB:WBGene00003884 ZFIN:ZDB-GENE-991019-4	C		Seeded From UniProt	complete
part_of	GO:0005871	kinesin complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0002948 FB:FBgn0004378 MGI:MGI:109202 MGI:MGI:1098229 PANTHER:PTN000648413 RGD:1303035 UniProtKB:D6XFK9 UniProtKB:O77382 UniProtKB:Q57UW8 UniProtKB:Q57X99 UniProtKB:Q582I0 WB:WBGene00003884	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004378 PANTHER:PTN000649235	C		Seeded From UniProt	complete
enables	GO:0003777	microtubule motor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0002948 FB:FBgn0003545 MGI:MGI:108426 MGI:MGI:1098229 MGI:MGI:1098264 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPAC3A11.14c RGD:621559 SGD:S000000159 SGD:S000000787 TAIR:locus:2115713 UniProtKB:A0A0B4KFR5 UniProtKB:A0A1D8PT88 UniProtKB:O77382 UniProtKB:P17120 UniProtKB:P33176 UniProtKB:Q02224 UniProtKB:Q2M1P5 UniProtKB:Q5T7B8 WB:WBGene00002222 WB:WBGene00002230 WB:WBGene00003884 WB:WBGene00006974 dictyBase:DDB_G0280967 dictyBase:DDB_G0291039	F		Seeded From UniProt	complete
enables	GO:0003777	microtubule motor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821 InterPro:IPR027640	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821	F		Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821 InterPro:IPR027640	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752	F		Seeded From UniProt	complete
enables	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	PMID:19838064^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005816	spindle pole body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0252	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Britto, M et al. (2016) Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism. Proc. Natl. Acad. Sci. U.S.A. 113 E7483-E7489 PubMed GONUTS page
↑ ^2.0 ^2.1 von Loeffelholz, O et al. (2019) Cryo-EM Structure (4.5-Å) of Yeast Kinesin-5-Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance. J. Mol. Biol. 431 864-872 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Hagan, I & Yanagida, M (1992) Kinesin-related cut7 protein associates with mitotic and meiotic spindles in fission yeast. Nature 356 74-6 PubMed GONUTS page
↑ ^4.0 ^4.1 Akera, T et al. (2015) Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore. Nat. Cell Biol. 17 1124-33 PubMed GONUTS page
↑ Rodriguez, AS et al. (2008) Protein complexes at the microtubule organizing center regulate bipolar spindle assembly. Cell Cycle 7 1246-53 PubMed GONUTS page
↑ Hagan, I & Yanagida, M (1990) Novel potential mitotic motor protein encoded by the fission yeast cut7+ gene. Nature 347 563-6 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Simeonov, DR et al. (2009) Distinct Kinesin-14 mitotic mechanisms in spindle bipolarity. Cell Cycle 8 3571-83 PubMed GONUTS page

[PMID:27834216-1] Britto, M et al. (2016) Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism. Proc. Natl. Acad. Sci. U.S.A. 113 E7483-E7489 PubMed GONUTS page

[PMID:30659798-2] 2.0 ^2.1 von Loeffelholz, O et al. (2019) Cryo-EM Structure (4.5-Å) of Yeast Kinesin-5-Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance. J. Mol. Biol. 431 864-872 PubMed GONUTS page

[PMID:1538784-3] 3.0 ^3.1 ^3.2 Hagan, I & Yanagida, M (1992) Kinesin-related cut7 protein associates with mitotic and meiotic spindles in fission yeast. Nature 356 74-6 PubMed GONUTS page

[PMID:26258632-4] 4.0 ^4.1 Akera, T et al. (2015) Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore. Nat. Cell Biol. 17 1124-33 PubMed GONUTS page

[PMID:18418055-5] Rodriguez, AS et al. (2008) Protein complexes at the microtubule organizing center regulate bipolar spindle assembly. Cell Cycle 7 1246-53 PubMed GONUTS page

[PMID:2145514-6] Hagan, I & Yanagida, M (1990) Novel potential mitotic motor protein encoded by the fission yeast cut7+ gene. Nature 347 563-6 PubMed GONUTS page

[PMID:16823372-7] 7.0 ^7.1 ^7.2 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19838064-9] Simeonov, DR et al. (2009) Distinct Kinesin-14 mitotic mechanisms in spindle bipolarity. Cell Cycle 8 3571-83 PubMed GONUTS page

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SCHPO:CUT7

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