SCHPO:CLR3

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	clr3
Protein Name(s)	Histone deacetylase clr3 Cryptic loci regulator 3
External Links
UniProt	P56523
EMBL	AF064207 CU329671
PIR	T43797
RefSeq	NP_595104.1
PDB	5IKK
PDBsum	5IKK
ProteinModelPortal	P56523
SMR	P56523
BioGrid	277339
DIP	DIP-59446N
IntAct	P56523
STRING	4896.SPBC800.03.1
MaxQB	P56523
PaxDb	P56523
PRIDE	P56523
EnsemblFungi	SPBC800.03.1
GeneID	2540821
KEGG	spo:SPBC800.03
EuPathDB	FungiDB:SPBC800.03
PomBase	SPBC800.03
HOGENOM	HOG000161343
InParanoid	P56523
KO	K11407
OMA	FQKIVMP
PhylomeDB	P56523
Reactome	R-SPO-3214815
PRO	PR:P56523
Proteomes	UP000002485
GO	GO:0000781 GO:0031934 GO:0000790 GO:0031618 GO:1990707 GO:0030874 GO:0005634 GO:0033553 GO:0070824 GO:0110129 GO:0004407 GO:0031078 GO:0032041 GO:0030702 GO:0000183 GO:0030466 GO:0006348 GO:0031048 GO:0016575 GO:0044154 GO:0035391 GO:0000122 GO:0016584
Gene3D	3.40.800.20
InterPro	IPR019154 IPR000286 IPR023801 IPR037138 IPR017321 IPR023696
PANTHER	PTHR10625
Pfam	PF09757 PF00850
PIRSF	PIRSF037919
PRINTS	PR01270
SUPFAM	SSF52768

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0090053	positive regulation of chromatin silencing at centromere	PMID:19136623^[1]	ECO:0000315			P		silencing defects in ckb1Δ cells was comparable with that caused by disruption of other heterochromatic genes, including clr3, (Fig. 1B).	complete CACAO 11287
part_of	GO:1990707	nuclear subtelomeric heterochromatin	PMID:17289569^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0110129	SHREC2 complex	PMID:19111658^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070824	SHREC complex	PMID:17289569^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044154	histone H3-K14 acetylation	GO_REF:0000111	ECO:0000305	curator inference used in manual assertion	GO:0031078	P		Seeded From UniProt	complete
involved_in	GO:0035391	maintenance of chromatin silencing at silent mating-type cassette	GO_REF:0000051	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0033553	rDNA heterochromatin	PMID:17289569^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031934	mating-type region heterochromatin	PMID:17289569^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031618	nuclear pericentric heterochromatin	PMID:17289569^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0031078	histone deacetylase activity (H3-K14 specific)	PMID:11884604^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031048	chromatin silencing by small RNA	PMID:19111658^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030874	nucleolar chromatin	PMID:11884604^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030702	chromatin silencing at centromere	PMID:9755190^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030702	chromatin silencing at centromere	PMID:19111658^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030466	chromatin silencing at silent mating-type cassette	PMID:8138176^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030466	chromatin silencing at silent mating-type cassette	PMID:8001791^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030466	chromatin silencing at silent mating-type cassette	PMID:19111658^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016584	nucleosome positioning	PMID:17289569^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	PMID:11884604^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006348	chromatin silencing at telomere	PMID:9755190^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006348	chromatin silencing at telomere	PMID:19111658^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16823372^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:11884604^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:11884604^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000183	chromatin silencing at rDNA	PMID:11884604^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16407326^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC36.05c	P	has_regulation_target:(PomBase:SPBCPT2R1.08c)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16407326^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC36.05c	P	has_regulation_target:(PomBase:SPAC212.11)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17289569^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0031078	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0032041	P		Seeded From UniProt	complete
enables	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137 UniProtKB-SubCell:SL-0047	C		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0779 UniProtKB-SubCell:SL-0276	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Shimada, A et al. (2009) Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin. Genes Dev. 23 18-23 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Sugiyama, T et al. (2007) SHREC, an effector complex for heterochromatic transcriptional silencing. Cell 128 491-504 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Motamedi, MR et al. (2008) HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Mol. Cell 32 778-90 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Bjerling, P et al. (2002) Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity. Mol. Cell. Biol. 22 2170-81 PubMed GONUTS page
↑ ^5.0 ^5.1 Grewal, SI et al. (1998) Histone deacetylase homologs regulate epigenetic inheritance of transcriptional silencing and chromosome segregation in fission yeast. Genetics 150 563-76 PubMed GONUTS page
↑ Ekwall, K & Ruusala, T (1994) Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast. Genetics 136 53-64 PubMed GONUTS page
↑ Thon, G et al. (1994) Three additional linkage groups that repress transcription and meiotic recombination in the mating-type region of Schizosaccharomyces pombe. Genetics 138 29-38 PubMed GONUTS page
↑ Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ ^9.0 ^9.1 Hansen, KR et al. (2006) Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. Nucleic Acids Res. 34 78-88 PubMed GONUTS page

[PMID:19136623-1] Shimada, A et al. (2009) Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin. Genes Dev. 23 18-23 PubMed GONUTS page

[PMID:17289569-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Sugiyama, T et al. (2007) SHREC, an effector complex for heterochromatic transcriptional silencing. Cell 128 491-504 PubMed GONUTS page

[PMID:19111658-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Motamedi, MR et al. (2008) HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Mol. Cell 32 778-90 PubMed GONUTS page

[PMID:11884604-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Bjerling, P et al. (2002) Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity. Mol. Cell. Biol. 22 2170-81 PubMed GONUTS page

[PMID:9755190-5] 5.0 ^5.1 Grewal, SI et al. (1998) Histone deacetylase homologs regulate epigenetic inheritance of transcriptional silencing and chromosome segregation in fission yeast. Genetics 150 563-76 PubMed GONUTS page

[PMID:8138176-6] Ekwall, K & Ruusala, T (1994) Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast. Genetics 136 53-64 PubMed GONUTS page

[PMID:8001791-7] Thon, G et al. (1994) Three additional linkage groups that repress transcription and meiotic recombination in the mating-type region of Schizosaccharomyces pombe. Genetics 138 29-38 PubMed GONUTS page

[PMID:16823372-8] Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:16407326-9] 9.0 ^9.1 Hansen, KR et al. (2006) Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. Nucleic Acids Res. 34 78-88 PubMed GONUTS page

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SCHPO:CLR3

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