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SCHPO:CLR3

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) clr3
Protein Name(s) Histone deacetylase clr3

Cryptic loci regulator 3

External Links
UniProt P56523
EMBL AF064207
CU329671
PIR T43797
RefSeq NP_595104.1
ProteinModelPortal P56523
BioGrid 277339
DIP DIP-59446N
MINT MINT-4691084
MaxQB P56523
EnsemblFungi [example_ID SPBC800.03.1]
GeneID 2540821
KEGG spo:SPBC800.03
EuPathDB FungiDB:SPBC800.03
PomBase SPBC800.03
HOGENOM HOG000161343
InParanoid P56523
KO K11407
OMA CYDDRMK
OrthoDB EOG75B8GB
PhylomeDB P56523
Reactome R-SPO-3371511
NextBio 20801938
PRO PR:P56523
Proteomes UP000002485
GO GO:0000781
GO:0031934
GO:0000790
GO:0031618
GO:1990707
GO:0030874
GO:0005634
GO:0033553
GO:0070824
GO:0004407
GO:0031078
GO:0032041
GO:0030702
GO:0000183
GO:0030466
GO:0006348
GO:0016575
GO:0070932
GO:0035391
GO:0000122
GO:0016584
GO:0006351
Gene3D 3.40.800.20
InterPro IPR019154
IPR000286
IPR023801
IPR017321
PANTHER PTHR10625
Pfam PF09757
PF00850
PIRSF PIRSF037919
PRINTS PR01270

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:16407326[1]

IGI: Inferred from Genetic Interaction

PomBase:SPBC36.05c

P

Seeded From UniProt

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:16407326[1]

IGI: Inferred from Genetic Interaction

PomBase:SPBC36.05c

P

Seeded From UniProt

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:17289569[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0000183

chromatin silencing at rDNA

PMID:11884604[3]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0000775

chromosome, centromeric region

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0137

C

Seeded From UniProt

GO:0000775

chromosome, centromeric region

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0047

C

Seeded From UniProt

GO:0000781

chromosome, telomeric region

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0779

C

Seeded From UniProt

GO:0000781

chromosome, telomeric region

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0276

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:11884604[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0004407

histone deacetylase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.5.1.98

F

Seeded From UniProt

GO:0004407

histone deacetylase activity

PMID:11884604[3]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0004407

histone deacetylase activity

PMID:11884604[3]

IMP: Inferred from Mutant Phenotype

-

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:16823372[4]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005694

chromosome

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0158

C

Seeded From UniProt

GO:0006348

chromatin silencing at telomere

PMID:9755190[5]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

GO:0016568

chromatin modification

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0156

P

Seeded From UniProt

GO:0016575

histone deacetylation

PMID:11884604[3]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0016584

nucleosome positioning

PMID:17289569[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

GO:0030466

chromatin silencing at silent mating-type cassette

PMID:8001791[6]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0030466

chromatin silencing at silent mating-type cassette

PMID:8138176[7]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0030702

chromatin silencing at centromere

PMID:9755190[5]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0030874

nucleolar chromatin

PMID:11884604[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0031078

histone deacetylase activity (H3-K14 specific)

PMID:11884604[3]

IMP: Inferred from Mutant Phenotype

-

F

Seeded From UniProt

GO:0031618

nuclear pericentric heterochromatin

PMID:17289569[2]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0031934

mating-type region heterochromatin

PMID:17289569[2]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0032041

NAD-dependent histone deacetylase activity (H3-K14 specific)

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.5.1.98

F

Seeded From UniProt

GO:0033553

rDNA heterochromatin

PMID:17289569[2]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0035391

maintenance of chromatin silencing at silent mating-type cassette

GO_REF:0000001

NAS: Non-traceable Author Statement

-

P

Seeded From UniProt

GO:0070824

SHREC complex

PMID:17289569[2]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0070932

histone H3 deacetylation

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.5.1.98

P

Seeded From UniProt

GO:0070932

histone H3 deacetylation

PMID:11884604[3]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:1990707

nuclear subtelomeric heterochromatin

PMID:17289569[2]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0090053

positive regulation of chromatin silencing at centromere

PMID:19136623[8]

IMP: Inferred from Mutant Phenotype

P

silencing defects in ckb1Δ cells was comparable with that caused by disruption of other heterochromatic genes, including clr3, (Fig. 1B).

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Hansen, KR et al. (2006) Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. Nucleic Acids Res. 34 78-88 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Sugiyama, T et al. (2007) SHREC, an effector complex for heterochromatic transcriptional silencing. Cell 128 491-504 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Bjerling, P et al. (2002) Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity. Mol. Cell. Biol. 22 2170-81 PubMed GONUTS page
  4. Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  5. 5.0 5.1 Grewal, SI et al. (1998) Histone deacetylase homologs regulate epigenetic inheritance of transcriptional silencing and chromosome segregation in fission yeast. Genetics 150 563-76 PubMed GONUTS page
  6. Thon, G et al. (1994) Three additional linkage groups that repress transcription and meiotic recombination in the mating-type region of Schizosaccharomyces pombe. Genetics 138 29-38 PubMed GONUTS page
  7. Ekwall, K & Ruusala, T (1994) Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast. Genetics 136 53-64 PubMed GONUTS page
  8. Shimada, A et al. (2009) Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin. Genes Dev. 23 18-23 PubMed GONUTS page