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SCHPO:ATM

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Species (Taxon ID) Schizosaccharomyces pombe (strain ATCC 38366 / 972) (Fission yeast). (taxon:284812)
Gene Name(s) tel1
Protein Name(s)
  • Serine/threonine-protein kinase tel1
  • ATM homolog
  • DNA-damage checkpoint kinase tel1
  • Telomere length regulation protein 1
External Links
UniProt Identifier ATM_SCHPO
UniProt Accessions O74630,
EMBL AB001995, CU329672,
PIR T43271,
RefSeq NP_588126.1,
Pfam PF02259, PF02260, PF00454, PF11640,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000781

chromosome, telomeric region

IEA: Inferred from Electronic Annotation

C

Source: UniProtKB-SubCell

GO:0005829

cytosol

IDA: Inferred from Direct Assay

C

Source: GeneDB_Spombe

GO:0005634

nucleus

IEA: Inferred from Electronic Annotation

C

Source: UniProtKB-SubCell

GO:0005524

ATP binding

IEA: Inferred from Electronic Annotation

F

Source: UniProtKB-KW

GO:0005515

protein binding

IPI: Inferred from Physical Interaction

F

Source: GeneDB_Spombe

GO:0004674

protein serine/threonine kinase activity

IEA: Inferred from Electronic Annotation

F

Source: UniProtKB-KW

GO:0006281

DNA repair

IEA: Inferred from Electronic Annotation

P

Source: UniProtKB-KW

GO:0016572

histone phosphorylation

IGI: Inferred from Genetic Interaction

P

Source: GeneDB_Spombe

GO:0000723

telomere maintenance

IMP: Inferred from Mutant Phenotype

P

Source: GeneDB_Spombe

GO:0000077

DNA damage checkpoint

GO_REF:0000001

NAS: Non-traceable Author Statement

P

GO:0004672

protein kinase activity

PMID:22302936[1]

IMP: Inferred from Mutant Phenotype

F

Figure 2 show that Tel 1 is required for phosphorylation of Thr 93 of Ccq1. Mutants without Tel 1 were unable to phosphorylate Ccq1.

complete

GO:0000166

nucleotide binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

GO:0000723

telomere maintenance

PMID:12196391[2]

IMP: Inferred from Mutant Phenotype

P

GO:0000781

chromosome, telomeric region

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0779

C

GO:0000781

chromosome, telomeric region

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0276

C

GO:0004672

protein kinase activity

PMID:10430579[3]

TAS: Traceable Author Statement

F

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015519

F

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR021668

F

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0723

F

GO:0005515

protein binding

PMID:15964794[4]

IPI: Inferred from Physical Interaction

GeneDB_Spombe:SPBC6B1.09c

F

GO:0005524

ATP binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

GO:0005694

chromosome

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0158

C

GO:0005829

cytosol

PMID:16823372[5]

IDA: Inferred from Direct Assay

C

GO:0006281

DNA repair

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234

P

GO:0006468

protein phosphorylation

PMID:10430579[3]

TAS: Traceable Author Statement

P

GO:0006974

response to DNA damage stimulus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0227

P

GO:0016301

kinase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

F

GO:0016310

phosphorylation

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

P

GO:0016568

chromatin modification

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0156

P

GO:0016572

histone phosphorylation

PMID:15964794[4]

IGI: Inferred from Genetic Interaction

GeneDB_Spombe:SPCC23B6.03c

P

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

GO:0016772

transferase activity, transferring phosphorus-containing groups

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

GO:0016773

phosphotransferase activity, alcohol group as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000403

F

GO:0016773

phosphotransferase activity, alcohol group as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018936

F


Notes

References

See Help:References for how to manage references in GONUTS.

  1. Yamazaki, H et al. (2012) Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast. Genes Dev. 26 241-6 PubMed GONUTS page
  2. Nakamura, TM et al. (2002) Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics 161 1437-52 PubMed GONUTS page
  3. 3.0 3.1 Matsuura, A et al. (1999) Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3(+) and tel1(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+). Genetics 152 1501-12 PubMed GONUTS page
  4. 4.0 4.1 You, Z et al. (2005) ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol. Cell. Biol. 25 5363-79 PubMed GONUTS page
  5. Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page