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SCHPO:ATM
Contents
| Species (Taxon ID) | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812) | |
| Gene Name(s) | tel1 | |
| Protein Name(s) | Serine/threonine-protein kinase tel1
ATM homolog DNA-damage checkpoint kinase tel1 Telomere length regulation protein 1 | |
| External Links | ||
| UniProt | O74630 | |
| EMBL | AB001995 CU329672 | |
| PIR | T43271 | |
| RefSeq | NP_588126.1 | |
| ProteinModelPortal | O74630 | |
| BioGrid | 275779 | |
| IntAct | O74630 | |
| STRING | 4896.SPCC23B6.03c.1 | |
| iPTMnet | O74630 | |
| PaxDb | O74630 | |
| PRIDE | O74630 | |
| EnsemblFungi | SPCC23B6.03c.1 | |
| GeneID | 2539209 | |
| KEGG | spo:SPCC23B6.03c | |
| EuPathDB | FungiDB:SPCC23B6.03c | |
| PomBase | SPCC23B6.03c | |
| InParanoid | O74630 | |
| KO | K04728 | |
| OMA | CGWSAFQ | |
| Reactome | R-SPO-2559586 R-SPO-5693548 R-SPO-5693565 R-SPO-6804756 | |
| PRO | PR:O74630 | |
| Proteomes | UP000002485 | |
| GO | GO:0000781 GO:0005829 GO:0005634 GO:0005524 GO:0004672 GO:0004674 GO:0006974 GO:0000077 GO:0006975 GO:1990853 GO:0008630 GO:1904262 GO:0045739 GO:1904514 GO:1904291 GO:0000723 | |
| Gene3D | 1.10.1070.11 | |
| InterPro | IPR003152 IPR011009 IPR000403 IPR036940 IPR018936 IPR003151 IPR014009 IPR021668 | |
| Pfam | PF02259 PF02260 PF00454 PF11640 | |
| SMART | SM01343 SM00146 SM01342 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS51189 PS51190 PS00915 PS00916 PS50290 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005829 |
cytosol |
ECO:0000314 |
C |
Source: GeneDB_Spombe |
Missing: reference | |||||
| GO:0005515 |
protein binding |
ECO:0000021 |
F |
Source: GeneDB_Spombe |
Missing: with/from, reference | |||||
| GO:0016572 |
histone phosphorylation |
ECO:0000316 |
P |
Source: GeneDB_Spombe |
Missing: with/from, reference | |||||
| GO:0000723 |
telomere maintenance |
ECO:0000315 |
P |
Source: GeneDB_Spombe |
Missing: reference | |||||
| GO:0000077 |
DNA damage checkpoint |
ECO:0000303 |
P |
complete | ||||||
| GO:0004672 |
protein kinase activity |
ECO:0000315 |
F |
Figure 2 show that Tel 1 is required for phosphorylation of Thr 93 of Ccq1. Mutants without Tel 1 were unable to phosphorylate Ccq1. |
complete | |||||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990853 |
histone H2A SQE motif phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0000723 |
telomere maintenance |
ECO:0000315 |
P |
complete | ||||||
|
involved_in |
GO:1904514 |
positive regulation of initiation of premeiotic DNA replication |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904291 |
positive regulation of mitotic DNA damage checkpoint |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045739 |
positive regulation of DNA repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006975 |
DNA damage induced protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(PomBase:SPAC694.06c) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000723 |
telomere maintenance |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
PomBase:SPBC216.05 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000723 |
telomere maintenance |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
PomBase:SPAC9E9.08 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904262 |
negative regulation of TORC1 signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107202 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107202 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107202 |
P |
Seeded From UniProt |
complete | ||
| GO:0005829 |
cytosol |
ECO:0000314 |
C |
complete | ||||||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0045035 |
C |
Seeded From UniProt |
complete | ||
| GO:0006468 |
protein phosphorylation |
ECO:0000304 |
P |
complete | ||||||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001673294 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000723 |
telomere maintenance |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0045035 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000077 |
DNA damage checkpoint |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107202 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000077 |
DNA damage checkpoint |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000723 |
telomere maintenance |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010212 |
response to ionizing radiation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016572 |
histone phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000781 |
chromosome, telomeric region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Yamazaki, H et al. (2012) Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast. Genes Dev. 26 241-6 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Nakamura, TM et al. (2004) Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast. Mol. Cell. Biol. 24 6215-30 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Nakamura, TM et al. (2002) Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics 161 1437-52 PubMed GONUTS page
- ↑ 4.0 4.1 Tougan, T et al. (2010) The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe. Cell Cycle 9 4688-702 PubMed GONUTS page
- ↑ 5.0 5.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
- ↑ Zhao, H et al. (2003) Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast. Mol. Cell. Biol. 23 8395-403 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Matsuura, A et al. (1999) Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3(+) and tel1(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+). Genetics 152 1501-12 PubMed GONUTS page
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- GO:0016310 ! phosphorylation
- GO:0045739 ! positive regulation of DNA repair
- GO:1904291 ! positive regulation of mitotic DNA damage checkpoint
- GO:1904514 ! positive regulation of initiation of premeiotic DNA replication
- GO:0005515 ! protein binding
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
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