It is now the 1st OPEN Period for CACAO Fall 2017! It will end on Sunday September 24, 2017 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

SCHPO:ATM

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Schizosaccharomyces pombe (strain ATCC 38366 / 972) (Fission yeast). (taxon:284812)
Gene Name(s) tel1
Protein Name(s)
  • Serine/threonine-protein kinase tel1
  • ATM homolog
  • DNA-damage checkpoint kinase tel1
  • Telomere length regulation protein 1
External Links
UniProt Identifier ATM_SCHPO
UniProt Accessions O74630,
EMBL AB001995, CU329672,
PIR T43271,
RefSeq NP_588126.1,
Pfam PF02259, PF02260, PF00454, PF11640,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000781

chromosome, telomeric region

IEA: Inferred from Electronic Annotation

C

Source: UniProtKB-SubCell

GO:0005829

cytosol

IDA: Inferred from Direct Assay

C

Source: GeneDB_Spombe

GO:0005634

nucleus

IEA: Inferred from Electronic Annotation

C

Source: UniProtKB-SubCell

GO:0005524

ATP binding

IEA: Inferred from Electronic Annotation

F

Source: UniProtKB-KW

GO:0005515

protein binding

IPI: Inferred from Physical Interaction

F

Source: GeneDB_Spombe

GO:0004674

protein serine/threonine kinase activity

IEA: Inferred from Electronic Annotation

F

Source: UniProtKB-KW

GO:0006281

DNA repair

IEA: Inferred from Electronic Annotation

P

Source: UniProtKB-KW

GO:0016572

histone phosphorylation

IGI: Inferred from Genetic Interaction

P

Source: GeneDB_Spombe

GO:0000723

telomere maintenance

IMP: Inferred from Mutant Phenotype

P

Source: GeneDB_Spombe

GO:0000077

DNA damage checkpoint

GO_REF:0000001

NAS: Non-traceable Author Statement

P

GO:0004672

protein kinase activity

PMID:22302936[1]

IMP: Inferred from Mutant Phenotype

F

Figure 2 show that Tel 1 is required for phosphorylation of Thr 93 of Ccq1. Mutants without Tel 1 were unable to phosphorylate Ccq1.

complete

GO:0000166

nucleotide binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

GO:0000723

telomere maintenance

PMID:12196391[2]

IMP: Inferred from Mutant Phenotype

P

GO:0000781

chromosome, telomeric region

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0779

C

GO:0000781

chromosome, telomeric region

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0276

C

GO:0004672

protein kinase activity

PMID:10430579[3]

TAS: Traceable Author Statement

F

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015519

F

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR021668

F

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0723

F

GO:0005515

protein binding

PMID:15964794[4]

IPI: Inferred from Physical Interaction

GeneDB_Spombe:SPBC6B1.09c

F

GO:0005524

ATP binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

GO:0005694

chromosome

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0158

C

GO:0005829

cytosol

PMID:16823372[5]

IDA: Inferred from Direct Assay

C

GO:0006281

DNA repair

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234

P

GO:0006468

protein phosphorylation

PMID:10430579[3]

TAS: Traceable Author Statement

P

GO:0006974

response to DNA damage stimulus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0227

P

GO:0016301

kinase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

F

GO:0016310

phosphorylation

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

P

GO:0016568

chromatin modification

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0156

P

GO:0016572

histone phosphorylation

PMID:15964794[4]

IGI: Inferred from Genetic Interaction

GeneDB_Spombe:SPCC23B6.03c

P

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

GO:0016772

transferase activity, transferring phosphorus-containing groups

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

GO:0016773

phosphotransferase activity, alcohol group as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000403

F

GO:0016773

phosphotransferase activity, alcohol group as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018936

F


Notes

References

See Help:References for how to manage references in GONUTS.

  1. Yamazaki, H et al. (2012) Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast. Genes Dev. 26 241-6 PubMed GONUTS page
  2. Nakamura, TM et al. (2002) Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics 161 1437-52 PubMed GONUTS page
  3. 3.0 3.1 Matsuura, A et al. (1999) Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3(+) and tel1(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+). Genetics 152 1501-12 PubMed GONUTS page
  4. 4.0 4.1 You, Z et al. (2005) ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol. Cell. Biol. 25 5363-79 PubMed GONUTS page
  5. Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page