SCHPO:ABP1

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	abp1
Protein Name(s)	ARS-binding protein 1
External Links
UniProt	P49777
EMBL	U39079 CU329671
PIR	T39281
RefSeq	NP_596460.1
PDB	1IUF
PDBsum	1IUF
ProteinModelPortal	P49777
SMR	P49777
BioGrid	276515
IntAct	P49777
STRING	4896.SPBC1105.04c.1
iPTMnet	P49777
MaxQB	P49777
PaxDb	P49777
PRIDE	P49777
EnsemblFungi	SPBC1105.04c.1
GeneID	2539971
KEGG	spo:SPBC1105.04c
EuPathDB	FungiDB:SPBC1105.04c
PomBase	SPBC1105.04c
HOGENOM	HOG000033772
InParanoid	P49777
OMA	WLDRFKS
PhylomeDB	P49777
EvolutionaryTrace	P49777
PRO	PR:P49777
Proteomes	UP000002485
GO	GO:0000780 GO:0031934 GO:0000790 GO:0005634 GO:0019237 GO:0043565 GO:0030702 GO:0007535 GO:0000070 GO:1903212
InterPro	IPR004875 IPR009057 IPR006600
Pfam	PF03184 PF03221
SMART	SM00674
SUPFAM	SSF46689
PROSITE	PS51253

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019237	centromeric DNA binding	PMID:9024682^[1]	ECO:0000314			F			complete
	GO:0000070	mitotic sister chromatid segregation	PMID:10733588^[2]	ECO:0000316			P			complete
	GO:0000780	condensed nuclear chromosome, centromeric region	PMID:9024682^[1]	ECO:0000314			C			complete
	GO:0005515	protein binding	PMID:17112379^[3]	ECO:0000021			F			complete
	GO:0046983	protein dimerization activity	PMID:17072883^[4]	ECO:0000303			F			complete
	GO:0030702	chromatin silencing at centromere	PMID:12130537^[5]	ECO:0000315			P			complete
	GO:0005634	nucleus	PMID:16823372^[6]	ECO:0000314			C			complete
	GO:0016570	histone modification	PMID:12130537^[5]	ECO:0000315			P			complete
	GO:0000790	nuclear chromatin	PMID:17072883^[4]	ECO:0000305		GO:0000780	C			complete
	GO:0006270	DNA-dependent DNA replication initiation	PMID:17112379^[3]	ECO:0000316			P			complete
	GO:2000105	positive regulation of DNA-dependent DNA replication	PMID:21151105^[7]	ECO:0000315			P		Figure 1	complete
involved_in	GO:1903212	protein localization to mating-type region heterochromatin	PMID:18354497^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(PomBase:SPAC1142.03c)	Seeded From UniProt	complete
	GO:0000070	mitotic sister chromatid segregation	PMID:10733588^[2]	ECO:0000316		GeneDB_Spombe:SPAC9E9.10c	P			complete
enables	GO:0043565	sequence-specific DNA binding	PMID:8552670^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:18420) occurs_at:(SO:0002004)	Seeded From UniProt	complete
	GO:0000780	condensed nuclear chromosome, centromeric region	PMID:9024682^[1]	ECO:0000314			C			complete
part_of	GO:0031934	mating-type region heterochromatin	PMID:18354497^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0000790	nuclear chromatin	GO_REF:0000001	ECO:0000305		GO:0000780	C			complete
involved_in	GO:0030702	chromatin silencing at centromere	PMID:12130537^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019237	centromeric DNA binding	PMID:9024682^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001796)	Seeded From UniProt	complete
enables	GO:0019237	centromeric DNA binding	PMID:10733588^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007535	donor selection	PMID:18354497^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0005515	protein binding	PMID:17112379^[3]	ECO:0000021		GeneDB_Spombe:SPBC1347.10	F			complete
part_of	GO:0005634	nucleus	PMID:16823372^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:29610759^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0001789)	Seeded From UniProt	complete
	GO:0005634	nucleus	PMID:16823372^[6]	ECO:0000314			C			complete
part_of	GO:0000790	nuclear chromatin	PMID:29610759^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(PomBase:SPAC1142.03c) part_of:(CL:0002674)	Seeded From UniProt	complete
	GO:0006270	DNA-dependent DNA replication initiation	PMID:17112379^[3]	ECO:0000315			P			complete
part_of	GO:0000780	condensed nuclear chromosome, centromeric region	PMID:9024682^[1]	ECO:0000305	curator inference used in manual assertion	GO:0019237	C		Seeded From UniProt	complete
involved_in	GO:0000070	mitotic sister chromatid segregation	PMID:10733588^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPAC9E9.10c	P		Seeded From UniProt	complete
	GO:0016570	histone modification	PMID:12130537^[5]	ECO:0000315			P			complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004875	F		Seeded From UniProt	complete
	GO:0019237	centromeric DNA binding	PMID:9024682^[1]	ECO:0000314			F			complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009057	F		Seeded From UniProt	complete
	GO:0030702	chromatin silencing at centromere	PMID:12130537^[5]	ECO:0000315			P			complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Halverson, D et al. (1997) A centromere DNA-binding protein from fission yeast affects chromosome segregation and has homology to human CENP-B. J. Cell Biol. 136 487-500 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Baum, M & Clarke, L (2000) Fission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome segregation. Mol. Cell. Biol. 20 2852-64 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Locovei, AM et al. (2006) The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast. Cell Div 1 27 PubMed GONUTS page
↑ ^4.0 ^4.1 Aslett, M & Wood, V (2006) Gene Ontology annotation status of the fission yeast genome: preliminary coverage approaches 100%. Yeast 23 913-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Nakagawa, H et al. (2002) Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications. Genes Dev. 16 1766-78 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ Zaratiegui, M et al. (2011) CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR. Nature 469 112-5 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Aguilar-Arnal, L et al. (2008) The fission yeast homologue of CENP-B, Abp1, regulates directionality of mating-type switching. EMBO J. 27 1029-38 PubMed GONUTS page
↑ Murakami, Y et al. (1996) Identification, purification, and molecular cloning of autonomously replicating sequence-binding protein 1 from fission yeast Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. U.S.A. 93 502-7 PubMed GONUTS page
↑ ^10.0 ^10.1 Raimondi, C et al. (2018) Molecular signature of the imprintosome complex at the mating-type locus in fission yeast. Microb Cell 5 169-183 PubMed GONUTS page

[PMID:9024682-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Halverson, D et al. (1997) A centromere DNA-binding protein from fission yeast affects chromosome segregation and has homology to human CENP-B. J. Cell Biol. 136 487-500 PubMed GONUTS page

[PMID:10733588-2] 2.0 ^2.1 ^2.2 ^2.3 Baum, M & Clarke, L (2000) Fission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome segregation. Mol. Cell. Biol. 20 2852-64 PubMed GONUTS page

[PMID:17112379-3] 3.0 ^3.1 ^3.2 ^3.3 Locovei, AM et al. (2006) The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast. Cell Div 1 27 PubMed GONUTS page

[PMID:17072883-4] 4.0 ^4.1 Aslett, M & Wood, V (2006) Gene Ontology annotation status of the fission yeast genome: preliminary coverage approaches 100%. Yeast 23 913-9 PubMed GONUTS page

[PMID:12130537-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Nakagawa, H et al. (2002) Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications. Genes Dev. 16 1766-78 PubMed GONUTS page

[PMID:16823372-6] 6.0 ^6.1 ^6.2 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:21151105-7] Zaratiegui, M et al. (2011) CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR. Nature 469 112-5 PubMed GONUTS page

[PMID:18354497-8] 8.0 ^8.1 ^8.2 Aguilar-Arnal, L et al. (2008) The fission yeast homologue of CENP-B, Abp1, regulates directionality of mating-type switching. EMBO J. 27 1029-38 PubMed GONUTS page

[PMID:8552670-9] Murakami, Y et al. (1996) Identification, purification, and molecular cloning of autonomously replicating sequence-binding protein 1 from fission yeast Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. U.S.A. 93 502-7 PubMed GONUTS page

[PMID:29610759-10] 10.0 ^10.1 Raimondi, C et al. (2018) Molecular signature of the imprintosome complex at the mating-type locus in fission yeast. Microb Cell 5 169-183 PubMed GONUTS page

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SCHPO:ABP1

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