RAT:UBR5

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Ubr5 (synonyms: Dd5, Edd, Edd1, Hyd)
Protein Name(s)	E3 ubiquitin-protein ligase UBR5 100 kDa protein E3 ubiquitin-protein ligase, HECT domain-containing 1 Hyperplastic discs protein homolog
External Links
UniProt	Q62671
EMBL	X64411
PIR	S22659
UniGene	Rn.54812
PDB	3NTW
PDBsum	3NTW
STRING	10116.ENSRNOP00000009115
PhosphoSite	Q62671
PaxDb	Q62671
PRIDE	Q62671
UCSC	RGD:621236
RGD	621236
eggNOG	COG5021
HOGENOM	HOG000046848
InParanoid	Q62671
UniPathway	UPA00143
PRO	PR:Q62671
Proteomes	UP000002494
Genevestigator	Q62671
GO	GO:0005737 GO:0005829 GO:0005634 GO:0016874 GO:0019904 GO:0003723 GO:0061630 GO:0004842 GO:0008270 GO:0006974 GO:0006281 GO:2000780 GO:1901315 GO:0050847 GO:0016567 GO:0042787
Gene3D	1.10.1900.10 2.130.10.30
InterPro	IPR024725 IPR000569 IPR002004 IPR009091 IPR003126 IPR013993
Pfam	PF11547 PF00632 PF00658 PF02207
SMART	SM00119 SM00517 SM00396
SUPFAM	SSF50985 SSF56204 SSF63570
PROSITE	PS50237 PS51309 PS51157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0061630	ubiquitin protein ligase activity	PMID:7708685^[1]	ECO:0000315			F	See Figure 2 for evidence of E3 ubiquitin-protein ligase activity. Note that Genbank PIR S22659 has been replaced with PIR Q62671.3 since the publication of this paper.	complete CACAO 10254
enables	GO:0061630	ubiquitin protein ligase activity	PMID:7708685^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
	GO:0061630	ubiquitin protein ligase activity	PMID:7708685^[1]	ECO:0000247		UniProtKB:Q05086	F	Fig 1B shows sequence alignment, including highly conserved cysteine residue necessary for Ubiquitin thioester formation.	complete CACAO 10302
involved_in	GO:2000780	negative regulation of double-strand break repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95071	P	Seeded From UniProt	complete
involved_in	GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95071	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95071	P	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:12239083^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:16554297^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:12239083^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12239083^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000883184 UniProtKB:O95071	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000134821 UniProtKB:O95071	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002431 PANTHER:PTN000883184 UniProtKB:O95071	C	Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000883184 UniProtKB:O95071	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002004 InterPro:IPR036053	F	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000569 InterPro:IPR035983	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003126	F	Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024725	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Huibregtse, JM et al. (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. U.S.A. 92 2563-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Oughtred, R et al. (2002) Characterization of rat100, a 300-kilodalton ubiquitin-protein ligase induced in germ cells of the rat testis and similar to the Drosophila hyperplastic discs gene. Endocrinology 143 3740-7 PubMed GONUTS page
↑ Lim, NS et al. (2006) Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD function. J. Biol. Chem. 281 14376-82 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7708685-1] 1.0 ^1.1 ^1.2 Huibregtse, JM et al. (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. U.S.A. 92 2563-7 PubMed GONUTS page

[PMID:12239083-2] 2.0 ^2.1 ^2.2 Oughtred, R et al. (2002) Characterization of rat100, a 300-kilodalton ubiquitin-protein ligase induced in germ cells of the rat testis and similar to the Drosophila hyperplastic discs gene. Endocrinology 143 3740-7 PubMed GONUTS page

[PMID:16554297-3] Lim, NS et al. (2006) Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD function. J. Biol. Chem. 281 14376-82 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:UBR5

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