RAT:TRPV4

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Trpv4 (synonyms: Vroac)
Protein Name(s)	Transient receptor potential cation channel subfamily V member 4 TrpV4 Osm-9-like TRP channel 4 OTRPC4 Vanilloid receptor-related osmotically-activated channel VR-OAC
External Links
UniProt	Q9ERZ8
EMBL	AF263521
RefSeq	NP_076460.1 XP_006249528.1
UniGene	Rn.64508
ProteinModelPortal	Q9ERZ8
SMR	Q9ERZ8
BioGrid	249353
DIP	DIP-59600N
STRING	10116.ENSRNOP00000001586
BindingDB	Q9ERZ8
ChEMBL	CHEMBL2096684
GuidetoPHARMACOLOGY	510
TCDB	1.A.4.2.5
PhosphoSite	Q9ERZ8
PaxDb	Q9ERZ8
PRIDE	Q9ERZ8
Ensembl	ENSRNOT00000001586
GeneID	66026
KEGG	rno:66026
UCSC	RGD:69337
CTD	59341
RGD	69337
eggNOG	NOG278734
GeneTree	ENSGT00550000074425
HOGENOM	HOG000234630
HOVERGEN	HBG054085
InParanoid	Q9ERZ8
KO	K04973
OMA	NTLYFTR
OrthoDB	EOG70S74P
PhylomeDB	Q9ERZ8
TreeFam	TF314711
Reactome	REACT_198388
NextBio	614333
PRO	PR:Q9ERZ8
Proteomes	UP000002494
Genevestigator	Q9ERZ8
GO	GO:0005912 GO:0009986 GO:0005929 GO:0030864 GO:0031410 GO:0030175 GO:0005925 GO:0030426 GO:0016021 GO:0030027 GO:0005886 GO:0032587 GO:0003779 GO:0051015 GO:0043014 GO:0005524 GO:0048487 GO:0005262 GO:0005516 GO:0005261 GO:0008017 GO:0005034 GO:0005080 GO:0031532 GO:0007015 GO:0070509 GO:0007043 GO:0006874 GO:0071476 GO:0034605 GO:0071470 GO:0043622 GO:0042538 GO:0006971 GO:0046785 GO:0010977 GO:0007231 GO:0007204 GO:0031117 GO:0047484 GO:0030103
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR005821 IPR004729 IPR008347 IPR008348
PANTHER	PTHR10582:SF4
Pfam	PF12796 PF00520
PRINTS	PR01768 PR01769
SMART	SM00248
SUPFAM	SSF48403
TIGRFAMs	TIGR00870
PROSITE	PS50297 PS50088

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
NOT\|involved_in	GO:0008217	regulation of blood pressure	PMID:23136043^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0002027	regulation of heart rate	PMID:23136043^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:23136043^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043117	positive regulation of vascular permeability	PMID:23136043^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050891	multicellular organismal water homeostasis	PMID:23136043^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0047484	regulation of response to osmotic stress	PMID:23136043^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:23136043^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046785	microtubule polymerization	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043622	cortical microtubule organization	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031117	positive regulation of microtubule depolymerization	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030864	cortical actin cytoskeleton	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030175	filopodium	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0005881	cytoplasmic microtubule	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:20657843^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0071470	cellular response to osmotic stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	P	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	P	Seeded From UniProt	complete
involved_in	GO:0007043	cell-cell junction assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HBA0	P	Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HBA0	C	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HBA0	F	Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HBA0	F	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:20650893^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:20650893^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:20650893^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006971	hypotonic response	PMID:11081638^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	PMID:11081638^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0071476	cellular hypotonic response	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926945 PANTHER:PTN000061708 UniProtKB:F1RIT1 UniProtKB:Q9HBA0	P	Seeded From UniProt	complete
involved_in	GO:0007231	osmosensory signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926945 PANTHER:PTN000061708	P	Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000061708 RGD:69337 UniProtKB:F1RIT1	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926945 PANTHER:PTN000061708 UniProtKB:Q9HBA0	P	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926945 PANTHER:PTN000061708 UniProtKB:F1RIT1	C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000061616 RGD:628841 RGD:69335 UniProtKB:Q9H1D0 UniProtKB:Q9NQA5	C	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341787 MGI:MGI:1341836 MGI:MGI:1926945 MGI:MGI:1927259 MGI:MGI:2429764 PANTHER:PTN000832860 RGD:620636 RGD:69335 RGD:69337 SGD:S000005613 UniProtKB:F1RIT1 UniProtKB:Q9H1D0 UniProtKB:Q9HBA0 UniProtKB:Q9NQA5 WB:WBGene00003889	F	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341787 MGI:MGI:2181407 PANTHER:PTN000061616	F	Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:1903759	signal transduction involved in regulation of aerobic respiration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:1903444	negative regulation of brown fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0071642	positive regulation of macrophage inflammatory protein 1 alpha production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0071477	cellular hypotonic salinity response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0071476	cellular hypotonic response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0071470	cellular response to osmotic stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0043117	positive regulation of vascular permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0042538	hyperosmotic salinity response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	F	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0030103	vasopressin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	F	Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0007231	osmosensory signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0007043	cell-cell junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0006970	response to osmotic stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	C	Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	C	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	F	Seeded From UniProt	complete
enables	GO:0005034	osmosensor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	F	Seeded From UniProt	complete
involved_in	GO:0002024	diet induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P	Seeded From UniProt	complete
involved_in	GO:0097497	blood vessel endothelial cell delamination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P	Seeded From UniProt	complete
involved_in	GO:0071476	cellular hypotonic response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P	Seeded From UniProt	complete
involved_in	GO:0060351	cartilage development involved in endochondral bone morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P	Seeded From UniProt	complete
involved_in	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P	Seeded From UniProt	complete
involved_in	GO:0043117	positive regulation of vascular permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	F	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	F	Seeded From UniProt	complete
enables	GO:0015275	stretch-activated, cation-selective, calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	F	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	C	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	F	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	F	Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	F	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821 InterPro:IPR008347 InterPro:IPR008348 InterPro:IPR024862	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821 InterPro:IPR008347 InterPro:IPR008348 InterPro:IPR024862	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008347 InterPro:IPR008348 InterPro:IPR024862	C	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C	Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0009	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Thorneloe, KS et al. (2012) An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci Transl Med 4 159ra148 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 ^2.20 Goswami, C et al. (2010) Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells. PLoS ONE 5 e11654 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Shukla, AK et al. (2010) Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. J. Biol. Chem. 285 30115-25 PubMed GONUTS page
↑ ^4.0 ^4.1 Liedtke, W et al. (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103 525-35 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23136043-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Thorneloe, KS et al. (2012) An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci Transl Med 4 159ra148 PubMed GONUTS page

[PMID:20657843-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 ^2.20 Goswami, C et al. (2010) Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells. PLoS ONE 5 e11654 PubMed GONUTS page

[PMID:20650893-3] 3.0 ^3.1 ^3.2 Shukla, AK et al. (2010) Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. J. Biol. Chem. 285 30115-25 PubMed GONUTS page

[PMID:11081638-4] 4.0 ^4.1 Liedtke, W et al. (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103 525-35 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:TRPV4

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