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PMID:20657843

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Citation

Goswami, C, Kuhn, J, Heppenstall, PA and Hucho, T (2010) Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells. PLoS ONE 5:e11654

Abstract

TRPV4 and the cellular cytoskeleton have each been reported to influence cellular mechanosensitive processes as well as the development of mechanical hyperalgesia. If and how TRPV4 interacts with the microtubule and actin cytoskeleton at a molecular and functional level is not known.

Links

PubMed PMC2906515 Online version:10.1371/journal.pone.0011654

Keywords

Actins/metabolism; Animals; Cell Line, Tumor; Cytoskeleton/metabolism; Immunohistochemistry; Immunoprecipitation; Male; Mice; Neurofilament Proteins/metabolism; Protein Binding; Rats; TRPV Cation Channels/metabolism; Tubulin/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:TRPV4

located_in

GO:0005925: focal adhesion

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

located_in

GO:0030426: growth cone

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

located_in

GO:0030175: filopodium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

located_in

GO:0030864: cortical actin cytoskeleton

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

located_in

GO:0030027: lamellipodium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

located_in

GO:0032587: ruffle membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

involved_in

GO:0070509: calcium ion import

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:TRPV4

enables

GO:0005262: calcium channel activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:TRPV4

colocalizes_with

GO:0005881: cytoplasmic microtubule

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

enables

GO:0008017: microtubule binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:TRPV4

part_of

GO:0030175: filopodium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

part_of

GO:0030864: cortical actin cytoskeleton

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

involved_in

GO:0031117: positive regulation of microtubule depolymerization

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:TRPV4

enables

GO:0043014: alpha-tubulin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:TRPV4

enables

GO:0048487: beta-tubulin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:TRPV4

enables

GO:0003779: actin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:TRPV4

enables

GO:0005080: protein kinase C binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:TRPV4

part_of

GO:0005925: focal adhesion

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

involved_in

GO:0007015: actin filament organization

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:TRPV4

involved_in

GO:0010977: negative regulation of neuron projection development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:TRPV4

part_of

GO:0030027: lamellipodium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

part_of

GO:0030426: growth cone

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

involved_in

GO:0031532: actin cytoskeleton reorganization

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:TRPV4

part_of

GO:0032587: ruffle membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TRPV4

involved_in

GO:0043622: cortical microtubule organization

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:TRPV4

involved_in

GO:0046785: microtubule polymerization

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:TRPV4

enables

GO:0051015: actin filament binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete


See also

References

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