RAT:SHC1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Shc1
Protein Name(s)	SHC-transforming protein 1 Src homology 2 domain-containing-transforming protein C1 SH2 domain protein C1
External Links
UniProt	Q5M824
EMBL	BC088298
RefSeq	NP_445969.2
UniGene	Rn.138818
ProteinModelPortal	Q5M824
SMR	Q5M824
BioGrid	250090
IntAct	Q5M824
STRING	10116.ENSRNOP00000028038
PhosphoSite	Q5M824
PaxDb	Q5M824
PRIDE	Q5M824
GeneID	85385
UCSC	RGD:620446
CTD	6464
RGD	620446
eggNOG	NOG315087
HOGENOM	HOG000231974
HOVERGEN	HBG050121
InParanoid	Q5M824
PhylomeDB	Q5M824
NextBio	617490
PRO	PR:Q5M824
Proteomes	UP000002494
Genevisible	Q5M824
GO	GO:0005737 GO:0010008 GO:0005634 GO:0005886 GO:0070435 GO:0005154 GO:0051219 GO:0001784 GO:0032403 GO:0019901 GO:0051721 GO:0030971 GO:0030036 GO:0000187 GO:0007568 GO:0001525 GO:0032869 GO:0007173 GO:0008286 GO:0035556 GO:0030182 GO:0031175 GO:0031100 GO:0045740 GO:0048661 GO:0045907 GO:0040008 GO:0051384 GO:0042542 GO:0001666 GO:0032868 GO:0035094 GO:0014070 GO:0009636
Gene3D	2.30.29.30 3.30.505.10
InterPro	IPR011993 IPR006019 IPR006020 IPR000980 IPR029586
PANTHER	PTHR10337:SF2
Pfam	PF00640 PF00017
PRINTS	PR00401 PR00629
SMART	SM00462 SM00252
SUPFAM	SSF55550
PROSITE	PS01179 PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29353	P	Seeded From UniProt	complete
part_of	GO:0070435	Shc-EGFR complex	PMID:7513704^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:7513704^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:7513704^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:17925406^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	PMID:7513704^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9QX70	F	Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	PMID:9582017^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q63604	F	Seeded From UniProt	complete
involved_in	GO:1990839	response to endothelin	PMID:27270176^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	PMID:11884620^[5]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3380	F	Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	PMID:11884620^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	PMID:10612430^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	PMID:8910399^[7]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2598	F	Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:12837289^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	PMID:16242150^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:17274988^[10]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1353820	F	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:11884620^[5]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3380	F	Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	PMID:16699171^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:17068140^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:11884620^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:11954667^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:15485499^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	PMID:15067377^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:17274988^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:15262993^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:16699171^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	PMID:17363458^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	PMID:16699171^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:11954667^[13]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:619758	P	Seeded From UniProt	complete
involved_in	GO:0006940	regulation of smooth muscle contraction	PMID:27270176^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12837289^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15375560^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15375560^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	PMID:9271418^[19]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2561	F	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:16439820^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:15262993^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2655364 MGI:MGI:98296 PANTHER:PTN000818658 RGD:620446	F	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000037430 RGD:620446	P	Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98296 PANTHER:PTN000037430	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000818658 RGD:620446 UniProtKB:P29353	C	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98296 PANTHER:PTN000037430 RGD:620446 UniProtKB:P29353	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029586	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029586	P	Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029586	F	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006019	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-RNO-9030763 Reactome:R-RNO-9030518 Reactome:R-RNO-9030485	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0341	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Sasaoka, T et al. (1994) Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J. Biol. Chem. 269 13689-94 PubMed GONUTS page
↑ Jensen, M et al. (2007) Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. J. Biol. Chem. 282 35179-86 PubMed GONUTS page
↑ McCarty, JH & Feinstein, SC (1998) Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction. Oncogene 16 1691-700 PubMed GONUTS page
↑ ^4.0 ^4.1 Miller, B et al. (2016) p66Shc regulates renal vascular tone in hypertension-induced nephropathy. J. Clin. Invest. 126 2533-46 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Ugi, S et al. (2002) Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Mol. Cell. Biol. 22 2375-87 PubMed GONUTS page
↑ Páez-Espinosa, EV et al. (1999) Insulin-induced tyrosine phosphorylation of Shc in liver, muscle and adipose tissue of insulin resistant rats. Mol. Cell. Endocrinol. 156 121-9 PubMed GONUTS page
↑ Kimura, T et al. (1996) Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. J. Biol. Chem. 271 27962-8 PubMed GONUTS page
↑ ^8.0 ^8.1 Sayeski, PP & Ali, MS (2003) The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation. Exp. Cell Res. 287 339-49 PubMed GONUTS page
↑ Yamamori, T et al. (2005) P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction. J. Mol. Cell. Cardiol. 39 992-5 PubMed GONUTS page
↑ ^10.0 ^10.1 Degoutin, J et al. (2007) ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation. FEBS Lett. 581 727-34 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Obreztchikova, M et al. (2006) Distinct signaling functions for Shc isoforms in the heart. J. Biol. Chem. 281 20197-204 PubMed GONUTS page
↑ Wada, T et al. (2007) Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells. Endocrinology 148 790-9 PubMed GONUTS page
↑ ^13.0 ^13.1 Fernandes, ML et al. (2001) Effects of age on elements of insulin-signaling pathway in central nervous system of rats. Endocrine 16 227-34 PubMed GONUTS page
↑ Hinsby, AM et al. (2004) ShcA regulates neurite outgrowth stimulated by neural cell adhesion molecule but not by fibroblast growth factor 2: evidence for a distinct fibroblast growth factor receptor response to neural cell adhesion molecule activation. J. Neurochem. 91 694-703 PubMed GONUTS page
↑ Yuji, J et al. (2004) Identification of p46 Shc expressed in the nuclei of hepatocytes with high proliferating activity: Study of regenerating rat liver. Int. J. Mol. Med. 13 721-8 PubMed GONUTS page
↑ ^16.0 ^16.1 Natalicchio, A et al. (2004) Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts. J. Biol. Chem. 279 43900-9 PubMed GONUTS page
↑ Balbis, A et al. (2007) Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes. Endocrinology 148 2944-54 PubMed GONUTS page
↑ ^18.0 ^18.1 Yoshida, S et al. (2004) Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats. Int. J. Oncol. 25 1089-96 PubMed GONUTS page
↑ Dankort, DL et al. (1997) Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation. Mol. Cell. Biol. 17 5410-25 PubMed GONUTS page
↑ Bianchi, G et al. (2006) p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia. Gerontology 52 17-23 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7513704-1] 1.0 ^1.1 ^1.2 ^1.3 Sasaoka, T et al. (1994) Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J. Biol. Chem. 269 13689-94 PubMed GONUTS page

[PMID:17925406-2] Jensen, M et al. (2007) Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. J. Biol. Chem. 282 35179-86 PubMed GONUTS page

[PMID:9582017-3] McCarty, JH & Feinstein, SC (1998) Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction. Oncogene 16 1691-700 PubMed GONUTS page

[PMID:27270176-4] 4.0 ^4.1 Miller, B et al. (2016) p66Shc regulates renal vascular tone in hypertension-induced nephropathy. J. Clin. Invest. 126 2533-46 PubMed GONUTS page

[PMID:11884620-5] 5.0 ^5.1 ^5.2 ^5.3 Ugi, S et al. (2002) Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Mol. Cell. Biol. 22 2375-87 PubMed GONUTS page

[PMID:10612430-6] Páez-Espinosa, EV et al. (1999) Insulin-induced tyrosine phosphorylation of Shc in liver, muscle and adipose tissue of insulin resistant rats. Mol. Cell. Endocrinol. 156 121-9 PubMed GONUTS page

[PMID:8910399-7] Kimura, T et al. (1996) Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. J. Biol. Chem. 271 27962-8 PubMed GONUTS page

[PMID:12837289-8] 8.0 ^8.1 Sayeski, PP & Ali, MS (2003) The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation. Exp. Cell Res. 287 339-49 PubMed GONUTS page

[PMID:16242150-9] Yamamori, T et al. (2005) P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction. J. Mol. Cell. Cardiol. 39 992-5 PubMed GONUTS page

[PMID:17274988-10] 10.0 ^10.1 Degoutin, J et al. (2007) ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation. FEBS Lett. 581 727-34 PubMed GONUTS page

[PMID:16699171-11] 11.0 ^11.1 ^11.2 Obreztchikova, M et al. (2006) Distinct signaling functions for Shc isoforms in the heart. J. Biol. Chem. 281 20197-204 PubMed GONUTS page

[PMID:17068140-12] Wada, T et al. (2007) Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells. Endocrinology 148 790-9 PubMed GONUTS page

[PMID:11954667-13] 13.0 ^13.1 Fernandes, ML et al. (2001) Effects of age on elements of insulin-signaling pathway in central nervous system of rats. Endocrine 16 227-34 PubMed GONUTS page

[PMID:15485499-14] Hinsby, AM et al. (2004) ShcA regulates neurite outgrowth stimulated by neural cell adhesion molecule but not by fibroblast growth factor 2: evidence for a distinct fibroblast growth factor receptor response to neural cell adhesion molecule activation. J. Neurochem. 91 694-703 PubMed GONUTS page

[PMID:15067377-15] Yuji, J et al. (2004) Identification of p46 Shc expressed in the nuclei of hepatocytes with high proliferating activity: Study of regenerating rat liver. Int. J. Mol. Med. 13 721-8 PubMed GONUTS page

[PMID:15262993-16] 16.0 ^16.1 Natalicchio, A et al. (2004) Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts. J. Biol. Chem. 279 43900-9 PubMed GONUTS page

[PMID:17363458-17] Balbis, A et al. (2007) Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes. Endocrinology 148 2944-54 PubMed GONUTS page

[PMID:15375560-18] 18.0 ^18.1 Yoshida, S et al. (2004) Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats. Int. J. Oncol. 25 1089-96 PubMed GONUTS page

[PMID:9271418-19] Dankort, DL et al. (1997) Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation. Mol. Cell. Biol. 17 5410-25 PubMed GONUTS page

[PMID:16439820-20] Bianchi, G et al. (2006) p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia. Gerontology 52 17-23 PubMed GONUTS page

[PMID:21873635-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:SHC1

Contents

Annotations

Notes

References

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